Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

H.F. Zheng; V. Forgetta; Y.H. Hsu; K. Estrada; A. Rosello-Diez; P.J. Leo; C.L. Dahia; K.H. Park-Min; J.H. Tobias; C. Kooperberg; A. Kleinman; U. Styrkarsdottir; C.T. Liu; C. Uggla; D.S. Evans; C.M. Nielson; K. Walter; U. Pettersson-Kymmer; S. McCarthy; J. Eriksson; T. Kwan; M. Jhamai; K. Trajanoska; Y. Memari; J. Min; J. Huang; P. Danecek; B. Wilmot; R. Li; W.C. Chou; L.E. Mokry; A. Moayyeri; M. Claussnitzer; C.H. Cheng; W. Cheung; C. Medina-Gomez; B. Ge; S.H. Chen; K. Choi; L. Oei; J. Fraser; R. Kraaij; M.A. Hibbs; C.L. Gregson; D. Paquette; A. Hofman; C. Wibom; G.J. Tranah; M. Marshall; B.B. Gardiner; K. Cremin; P. Auer; L. Hsu; S. Ring; J.Y. Tung; G. Thorleifsson; A.W. Enneman; N.M. van Schoor; L.C.P.G. de Groot; N. van der Velde; B. Melin; J.P. Kemp; C. Christiansen; A. Sayers; Y.H. Zhou; S. Calderari; J. van Rooij; C. Carlson; U. Peters; S. Berlivet; J. Dostie; A. G. Uitterlinden; S.R. Williams; C. Farber; D. Grinberg; A.Z. LaCroix; J. Haessler; D.I. Chasman; F. Giulianini; L.M. Rose; P.M. Ridker; J.A. Eisman; T.V. Nguyen; J.R. Center; X. Nogues; N. Garcia-Giralt; L.L. Launer; V. Gudnason; D. Mellstrom; L. Vandenput; N. Amin; C.M. van Duijn; M.K. Karlsson; O. Ljunggren; O. Svensson; G. Hallmans; F. Rousseau; S. Giroux; J. Bussiere; F.F. Rivadeneira; J.B. Richards

doi:10.1038/nature14878

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

H.F. Zheng
, V. Forgetta
, Y.H. Hsu
, K. Estrada
, A. Rosello-Diez
, P.J. Leo
, C.L. Dahia
, K.H. Park-Min
, J.H. Tobias
, C. Kooperberg
, A. Kleinman
, U. Styrkarsdottir
, C.T. Liu
, C. Uggla
, D.S. Evans
, C.M. Nielson
, K. Walter
, U. Pettersson-Kymmer
, S. McCarthy
, J. Eriksson

T. Kwan, M. Jhamai, K. Trajanoska, Y. Memari, J. Min, J. Huang, P. Danecek, B. Wilmot, R. Li, W.C. Chou, L.E. Mokry, A. Moayyeri, M. Claussnitzer, C.H. Cheng, W. Cheung, C. Medina-Gomez, B. Ge, S.H. Chen, K. Choi, L. Oei, J. Fraser, R. Kraaij, M.A. Hibbs, C.L. Gregson, D. Paquette, A. Hofman, C. Wibom, G.J. Tranah, M. Marshall, B.B. Gardiner, K. Cremin, P. Auer, L. Hsu, S. Ring, J.Y. Tung, G. Thorleifsson, A.W. Enneman, N.M. van Schoor, L.C.P.G. de Groot, N. van der Velde, B. Melin, J.P. Kemp, C. Christiansen, A. Sayers, Y.H. Zhou, S. Calderari, J. van Rooij, C. Carlson, U. Peters, S. Berlivet, J. Dostie, A. G. Uitterlinden, S.R. Williams, C. Farber, D. Grinberg, A.Z. LaCroix, J. Haessler, D.I. Chasman, F. Giulianini, L.M. Rose, P.M. Ridker, J.A. Eisman, T.V. Nguyen, J.R. Center, X. Nogues, N. Garcia-Giralt, L.L. Launer, V. Gudnason, D. Mellstrom, L. Vandenput, N. Amin, C.M. van Duijn, M.K. Karlsson, O. Ljunggren, O. Svensson, G. Hallmans, F. Rousseau, S. Giroux, J. Bussiere, F.F. Rivadeneira, J.B. Richards

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Original language	Undefined/Unknown
Pages (from-to)	112-117
Journal	Nature
Volume	526
Issue number	7571
DOIs	https://doi.org/10.1038/nature14878
Publication status	Published - 2015

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Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., ... Richards, J. B. (2015). Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 526(7571), 112-117. https://doi.org/10.1038/nature14878

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doi = "10.1038/nature14878",

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volume = "526",

pages = "112--117",

journal = "Nature",

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Zheng, HF, Forgetta, V, Hsu, YH, Estrada, K, Rosello-Diez, A, Leo, PJ, Dahia, CL, Park-Min, KH, Tobias, JH, Kooperberg, C, Kleinman, A, Styrkarsdottir, U, Liu, CT, Uggla, C, Evans, DS, Nielson, CM, Walter, K, Pettersson-Kymmer, U, McCarthy, S, Eriksson, J, Kwan, T, Jhamai, M, Trajanoska, K, Memari, Y, Min, J, Huang, J, Danecek, P, Wilmot, B, Li, R, Chou, WC, Mokry, LE, Moayyeri, A, Claussnitzer, M, Cheng, CH, Cheung, W, Medina-Gomez, C, Ge, B, Chen, SH, Choi, K, Oei, L, Fraser, J, Kraaij, R, Hibbs, MA, Gregson, CL, Paquette, D, Hofman, A, Wibom, C, Tranah, GJ, Marshall, M, Gardiner, BB, Cremin, K, Auer, P, Hsu, L, Ring, S, Tung, JY, Thorleifsson, G, Enneman, AW, van Schoor, NM, de Groot, LCPG, van der Velde, N, Melin, B, Kemp, JP, Christiansen, C, Sayers, A, Zhou, YH, Calderari, S, van Rooij, J, Carlson, C, Peters, U, Berlivet, S, Dostie, J, Uitterlinden, AG, Williams, SR, Farber, C, Grinberg, D, LaCroix, AZ, Haessler, J, Chasman, DI, Giulianini, F, Rose, LM, Ridker, PM, Eisman, JA, Nguyen, TV, Center, JR, Nogues, X, Garcia-Giralt, N, Launer, LL, Gudnason, V, Mellstrom, D, Vandenput, L, Amin, N, van Duijn, CM, Karlsson, MK, Ljunggren, O, Svensson, O, Hallmans, G, Rousseau, F, Giroux, S, Bussiere, J, Rivadeneira, FF & Richards, JB 2015, 'Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture', Nature, vol. 526, no. 7571, pp. 112-117. https://doi.org/10.1038/nature14878

TY - JOUR

T1 - Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

AU - Zheng, H.F.

AU - Forgetta, V.

AU - Hsu, Y.H.

AU - Estrada, K.

AU - Rosello-Diez, A.

AU - Leo, P.J.

AU - Dahia, C.L.

AU - Park-Min, K.H.

AU - Tobias, J.H.

AU - Kooperberg, C.

AU - Kleinman, A.

AU - Styrkarsdottir, U.

AU - Liu, C.T.

AU - Uggla, C.

AU - Evans, D.S.

AU - Nielson, C.M.

AU - Walter, K.

AU - Pettersson-Kymmer, U.

AU - McCarthy, S.

AU - Eriksson, J.

AU - Kwan, T.

AU - Jhamai, M.

AU - Trajanoska, K.

AU - Memari, Y.

AU - Min, J.

AU - Huang, J.

AU - Danecek, P.

AU - Wilmot, B.

AU - Li, R.

AU - Chou, W.C.

AU - Mokry, L.E.

AU - Moayyeri, A.

AU - Claussnitzer, M.

AU - Cheng, C.H.

AU - Cheung, W.

AU - Medina-Gomez, C.

AU - Ge, B.

AU - Chen, S.H.

AU - Choi, K.

AU - Oei, L.

AU - Fraser, J.

AU - Kraaij, R.

AU - Hibbs, M.A.

AU - Gregson, C.L.

AU - Paquette, D.

AU - Hofman, A.

AU - Wibom, C.

AU - Tranah, G.J.

AU - Marshall, M.

AU - Gardiner, B.B.

AU - Cremin, K.

AU - Auer, P.

AU - Hsu, L.

AU - Ring, S.

AU - Tung, J.Y.

AU - Thorleifsson, G.

AU - Enneman, A.W.

AU - van Schoor, N.M.

AU - de Groot, L.C.P.G.

AU - van der Velde, N.

AU - Melin, B.

AU - Kemp, J.P.

AU - Christiansen, C.

AU - Sayers, A.

AU - Zhou, Y.H.

AU - Calderari, S.

AU - van Rooij, J.

AU - Carlson, C.

AU - Peters, U.

AU - Berlivet, S.

AU - Dostie, J.

AU - Uitterlinden, A. G.

AU - Williams, S.R.

AU - Farber, C.

AU - Grinberg, D.

AU - LaCroix, A.Z.

AU - Haessler, J.

AU - Chasman, D.I.

AU - Giulianini, F.

AU - Rose, L.M.

AU - Ridker, P.M.

AU - Eisman, J.A.

AU - Nguyen, T.V.

AU - Center, J.R.

AU - Nogues, X.

AU - Garcia-Giralt, N.

AU - Launer, L.L.

AU - Gudnason, V.

AU - Mellstrom, D.

AU - Vandenput, L.

AU - Amin, N.

AU - van Duijn, C.M.

AU - Karlsson, M.K.

AU - Ljunggren, O.

AU - Svensson, O.

AU - Hallmans, G.

AU - Rousseau, F.

AU - Giroux, S.

AU - Bussiere, J.

AU - Rivadeneira, F.F.

AU - Richards, J.B.

PY - 2015

Y1 - 2015

U2 - 10.1038/nature14878

DO - 10.1038/nature14878

M3 - Article

C2 - 26367794

SN - 0028-0836

VL - 526

SP - 112

EP - 117

JO - Nature

JF - Nature

IS - 7571

ER -