White-matter changes on MRI as surrogate marker

Philip Scheltens; Frederik Barkhof; Franz Fazekas

doi:10.1017/S104161020300930X

White-matter changes on MRI as surrogate marker

Philip Scheltens^*
, Frederik Barkhof
, Franz Fazekas

^*Corresponding author for this work

University of Graz

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	International Psychogeriatrics
Volume	15
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1017/S104161020300930X
Publication status	Published - 7 Oct 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clinical trials
Dementia
MRI
pH
Vascular
White matter

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10.1017/S104161020300930X

Cite this

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AB - This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

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KW - pH

KW - Vascular

KW - White matter

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White-matter changes on MRI as surrogate marker

Abstract

UN SDGs

Keywords

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