Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model

Jenny L. Schnyder; Hanna K. de Jong; Emmanuel B. Bache; Reinier M. van Hest; Sabine Bélard; Thomas Hanscheid; Peter G. Kremsner; Martin P. Grobusch

doi:10.1016/j.cmi.2025.04.023

Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model

Jenny L. Schnyder
, Hanna K. de Jong
, Emmanuel B. Bache
, Reinier M. van Hest
, Sabine Bélard
, Thomas Hanscheid
, Peter G. Kremsner
, Martin P. Grobusch^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Original language	English
Pages (from-to)	1618-1622
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	31
Issue number	10
Early online date	2025
DOIs	https://doi.org/10.1016/j.cmi.2025.04.023
Publication status	Published - Oct 2025

Keywords

Alternative regimens
Atovaquone-proguanil
Chemoprophylaxis
Early discontinuation
Malaria
Plasmodium falciparum
Travel medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmi.2025.04.023

Which-trial-do-we-need-a-randomised-controlled-study-to-compare-the-protective-efficacy-of-early-post-exposure-disconti.pdfFinal published version, 441 KBLicence: Taverne

Cite this

Schnyder, J. L., de Jong, H. K., Bache, E. B., van Hest, R. M., Bélard, S., Hanscheid, T., Kremsner, P. G., & Grobusch, M. P. (2025). Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model. Clinical Microbiology and Infection, 31(10), 1618-1622. https://doi.org/10.1016/j.cmi.2025.04.023

Schnyder, Jenny L. ; de Jong, Hanna K. ; Bache, Emmanuel B. et al. / Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model. In: Clinical Microbiology and Infection. 2025 ; Vol. 31, No. 10. pp. 1618-1622.

@article{604926ccfa964d6cba6c88a0b349caf3,

title = "Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model",

keywords = "Alternative regimens, Atovaquone-proguanil, Chemoprophylaxis, Early discontinuation, Malaria, Plasmodium falciparum, Travel medicine",

author = "Schnyder, \{Jenny L.\} and \{de Jong\}, \{Hanna K.\} and Bache, \{Emmanuel B.\} and \{van Hest\}, \{Reinier M.\} and Sabine B{\'e}lard and Thomas Hanscheid and Kremsner, \{Peter G.\} and Grobusch, \{Martin P.\}",

year = "2025",

month = oct,

doi = "10.1016/j.cmi.2025.04.023",

language = "English",

volume = "31",

pages = "1618--1622",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

number = "10",

}

Schnyder, JL , de Jong, HK, Bache, EB, van Hest, RM, Bélard, S, Hanscheid, T, Kremsner, PG & Grobusch, MP 2025, 'Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model', Clinical Microbiology and Infection, vol. 31, no. 10, pp. 1618-1622. https://doi.org/10.1016/j.cmi.2025.04.023

Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model. / Schnyder, Jenny L.; de Jong, Hanna K.; Bache, Emmanuel B. et al.
In: Clinical Microbiology and Infection, Vol. 31, No. 10, 10.2025, p. 1618-1622.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

TY - JOUR

T1 - Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model

AU - Schnyder, Jenny L.

AU - de Jong, Hanna K.

AU - Bache, Emmanuel B.

AU - van Hest, Reinier M.

AU - Bélard, Sabine

AU - Hanscheid, Thomas

AU - Kremsner, Peter G.

AU - Grobusch, Martin P.

PY - 2025/10

Y1 - 2025/10

KW - Alternative regimens

KW - Atovaquone-proguanil

KW - Chemoprophylaxis

KW - Early discontinuation

KW - Malaria

KW - Plasmodium falciparum

KW - Travel medicine

UR - https://www.scopus.com/pages/publications/105005323787

U2 - 10.1016/j.cmi.2025.04.023

DO - 10.1016/j.cmi.2025.04.023

M3 - Comment/Letter to the editor

C2 - 40294866

SN - 1198-743X

VL - 31

SP - 1618

EP - 1622

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 10

ER -

Schnyder JL , de Jong HK, Bache EB, van Hest RM, Bélard S, Hanscheid T et al. Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model. Clinical Microbiology and Infection. 2025 Oct;31(10):1618-1622. Epub 2025. doi: 10.1016/j.cmi.2025.04.023

Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model

Keywords

UN SDGs

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