Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

Veronica van der Land; Channa T. Hijmans; Marieke de Ruiter; Henri J. M. M. Mutsaerts; Marjon H. Cnossen; Marc Engelen; Charles B. L. M. Majoie; Aart J. Nederveen; Martha A. Grootenhuis; Karin Fijnvandraat

doi:10.1111/bjh.13179

Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

Emma Children's Hospital/AMC
Erasmus University Rotterdam
Amsterdam University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 125years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options

Original language	English
Pages (from-to)	553-556
Number of pages	4
Journal	British journal of haematology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1111/bjh.13179
Publication status	Published - 1 Feb 2015

Keywords

Neurocognitive functioning
Sickle cell disease
Silent cerebral infarcts

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10.1111/bjh.13179

Volume-of-white-matter-hyperintensities-is-an-independent-predictor-of-intelligence-quotient-and-processing-speed-in-chi.pdfFinal published version, 250 KBLicence: Taverne

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van der Land, V., Hijmans, C. T., de Ruiter, M., Mutsaerts, H. J. M. M., Cnossen, M. H., Engelen, M., Majoie, C. B. L. M., Nederveen, A. J., Grootenhuis, M. A., & Fijnvandraat, K. (2015). Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease. British journal of haematology, 168(4), 553-556. https://doi.org/10.1111/bjh.13179

@article{3bc0aea3cdd14808b205b0c11f2d25b1,

title = "Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease",

abstract = "Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 125years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options",

keywords = "Neurocognitive functioning, Sickle cell disease, Silent cerebral infarcts",

author = "\{van der Land\}, Veronica and Hijmans, \{Channa T.\} and \{de Ruiter\}, Marieke and Mutsaerts, \{Henri J. M. M.\} and Cnossen, \{Marjon H.\} and Marc Engelen and Majoie, \{Charles B. L. M.\} and Nederveen, \{Aart J.\} and Grootenhuis, \{Martha A.\} and Karin Fijnvandraat",

year = "2015",

month = feb,

day = "1",

doi = "10.1111/bjh.13179",

language = "English",

volume = "168",

pages = "553--556",

journal = "British journal of haematology",

issn = "0007-1048",

publisher = "Wiley Blackwell",

number = "4",

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van der Land, V, Hijmans, CT, de Ruiter, M, Mutsaerts, HJMM, Cnossen, MH, Engelen, M , Majoie, CBLM , Nederveen, AJ , Grootenhuis, MA & Fijnvandraat, K 2015, 'Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease', British journal of haematology, vol. 168, no. 4, pp. 553-556. https://doi.org/10.1111/bjh.13179

Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease. / van der Land, Veronica; Hijmans, Channa T.; de Ruiter, Marieke et al.
In: British journal of haematology, Vol. 168, No. 4, 01.02.2015, p. 553-556.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

AU - van der Land, Veronica

AU - Hijmans, Channa T.

AU - de Ruiter, Marieke

AU - Mutsaerts, Henri J. M. M.

AU - Cnossen, Marjon H.

AU - Engelen, Marc

AU - Majoie, Charles B. L. M.

AU - Nederveen, Aart J.

AU - Grootenhuis, Martha A.

AU - Fijnvandraat, Karin

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 125years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options

AB - Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 125years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options

KW - Neurocognitive functioning

KW - Sickle cell disease

KW - Silent cerebral infarcts

UR - https://www.scopus.com/pages/publications/84923107854

U2 - 10.1111/bjh.13179

DO - 10.1111/bjh.13179

M3 - Article

C2 - 25303108

SN - 0007-1048

VL - 168

SP - 553

EP - 556

JO - British journal of haematology

JF - British journal of haematology

IS - 4

ER -

Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease

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