TY - JOUR
T1 - Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke study (VERiTAS): rationale and design
AU - Amin-Hanjani, Sepideh
AU - Rose-Finnell, Linda
AU - Richardson, DeJuran
AU - Ruland, Sean
AU - Pandey, Dilip
AU - Thulborn, Keith R.
AU - Liebeskind, David S.
AU - Zipfel, Gregory J.
AU - Elkind, Mitchell S. V.
AU - Kramer, Jeffrey
AU - Silver, Frank L.
AU - Kasner, Scott E.
AU - Caplan, Louis R.
AU - Derdeyn, Colin P.
AU - Gorelick, Philip B.
AU - Charbel, Fady T.
AU - AUTHOR GROUP
AU - Jacobs, Tom P.
AU - Xie, Hui
AU - Simkus, Vic
AU - Thulborn, Keith
AU - Flannery, Michael P.
AU - Ganin, Hagai
AU - Grysecwicz, Rebecca
AU - Khaja, Aslam
AU - Pedelty, Laura
AU - Testai, Fernando
AU - Watson, Karriem
AU - Mlinarevich, Nada
AU - Vo, Katie
AU - Foster, Glenn
AU - Ford, Andria
AU - Bradley, Abbie
AU - Alger, Jeffrey
AU - Godinez, Sergio
AU - Saver, Jeffrey
AU - Ali, Latisha
AU - Kim, Doojin
AU - Raychev, Radoslav
AU - Song, Sarah
AU - Ovbiagele, Bruce
AU - Smith, Hannah
AU - Hirsch, Joy
AU - Dashnaw, Stephen
AU - Meyers, Philip
AU - McNeill-Simaan, Edwina
AU - Mikulis, David
AU - Fierstra, Jorn
AU - Hlasny, Eugen
AU - Casaubon, Leanne K.
AU - Vergouwen, Mervyn
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Over one-third of ischaemic strokes occur in the posterior circulation, and a leading cause is atherosclerotic vertebrobasilar disease. Symptomatic vertebrobasilar disease carries a high annual recurrent stroke risk, averaging 10-15% per year. Endovascular angioplasty and stenting are increasingly used but carry risks, and the benefit remains unproven. Determining stroke predictors in this population is critical to identifying high-risk patients for future trials of intervention. Preliminary studies indicate that stroke risk in vertebrobasilar disease is strongly related to haemodynamic compromise, which can be measured noninvasively using quantitative magnetic resonance angiography. METHODS/STUDY DESIGN: The Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke (VERiTAS) study, a prospective multicentre NIH-funded observational study of symptomatic vertebrobasilar stenosis (≥50%) or occlusion, is designed to test the hypothesis that patients demonstrating compromised blood flow as assessed by quantitative magnetic resonance angiography are at higher stroke risk. The study will recruit 80 patients at six sites in North America over 4-years. Upon enrollment, subjects will undergo haemodynamic assessment with blinded quantitative magnetic resonance angiography to assess large vessel flow in the vertebrobasilar territory, and be prospectively designated as compromised or normal flow. Patients will be re-imaged with quantitative magnetic resonance angiography at 6-, 12-, and 24-months, and followed for 12-24-months for the primary end-point of stroke in the vertebrobasilar territory. CONCLUSION: The VERiTAS study is the first prospective study of haemodynamics and stroke risk in the posterior circulation. The results may impact the selection criteria for interventional candidates and also define a low-risk population in whom the risks of invasive interventions would be unnecessary
AB - BACKGROUND: Over one-third of ischaemic strokes occur in the posterior circulation, and a leading cause is atherosclerotic vertebrobasilar disease. Symptomatic vertebrobasilar disease carries a high annual recurrent stroke risk, averaging 10-15% per year. Endovascular angioplasty and stenting are increasingly used but carry risks, and the benefit remains unproven. Determining stroke predictors in this population is critical to identifying high-risk patients for future trials of intervention. Preliminary studies indicate that stroke risk in vertebrobasilar disease is strongly related to haemodynamic compromise, which can be measured noninvasively using quantitative magnetic resonance angiography. METHODS/STUDY DESIGN: The Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke (VERiTAS) study, a prospective multicentre NIH-funded observational study of symptomatic vertebrobasilar stenosis (≥50%) or occlusion, is designed to test the hypothesis that patients demonstrating compromised blood flow as assessed by quantitative magnetic resonance angiography are at higher stroke risk. The study will recruit 80 patients at six sites in North America over 4-years. Upon enrollment, subjects will undergo haemodynamic assessment with blinded quantitative magnetic resonance angiography to assess large vessel flow in the vertebrobasilar territory, and be prospectively designated as compromised or normal flow. Patients will be re-imaged with quantitative magnetic resonance angiography at 6-, 12-, and 24-months, and followed for 12-24-months for the primary end-point of stroke in the vertebrobasilar territory. CONCLUSION: The VERiTAS study is the first prospective study of haemodynamics and stroke risk in the posterior circulation. The results may impact the selection criteria for interventional candidates and also define a low-risk population in whom the risks of invasive interventions would be unnecessary
U2 - 10.1111/j.1747-4949.2010.00528.x
DO - 10.1111/j.1747-4949.2010.00528.x
M3 - Article
C2 - 21050408
SN - 1747-4930
VL - 5
SP - 499
EP - 505
JO - International journal of stroke
JF - International journal of stroke
IS - 6
ER -
SDG 3 Good Health and Well-being