TY - JOUR
T1 - Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates
T2 - a BEST Collaborative study
AU - BEST Collaborative Study Group
AU - Zalpuri, Saurabh
AU - Romeijn, Bas
AU - Allara, Elias
AU - Goldman, Mindy
AU - Kamel, Hany
AU - Gorlin, Jed
AU - Vassallo, Ralph
AU - Grégoire, Yves
AU - Goto, Naoko
AU - Flanagan, Peter
AU - Speedy, Joanna
AU - Buser, Andreas
AU - Kutner, Jose Mauro
AU - Magnussen, Karin
AU - Castrén, Johanna
AU - Culler, Liz
AU - Sussmann, Harry
AU - Prinsze, Femmeke J.
AU - Belanger, Kevin
AU - Compernolle, Veerle
AU - Tiberghien, Pierre
AU - Cardenas, Jose Manuel
AU - Gandhi, Manish J.
AU - West, Kamille A.
AU - Lee, Cheuk Kwong
AU - James, Sian
AU - Wells, Deanne
AU - Sutor, Laurie J.
AU - Wendel, Silvano
AU - Coleman, Matthew
AU - Seltsam, Axel
AU - Roden, Kimberly
AU - Steele, Whitney R.
AU - Bohonek, Milos
AU - Alcantara, Ramir
AU - Di Angelantonio, Emanuele
AU - van den Hurk, Katja
N1 - Funding Information:
We would like to thank Janice Norris from Blood Assurance, Inc, and Nicholas OʼSullivan and Victoria Sachser from the Welsh Blood Service, Clinical Services for their contribution to data collection. Additionally we want to thank all donors and staff at the participating blood services for their valuable contributions to transfusion.
Publisher Copyright:
© 2020 AABB
PY - 2020/3/1
Y1 - 2020/3/1
N2 - BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
AB - BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
UR - https://www.scopus.com/pages/publications/85079218106
U2 - 10.1111/trf.15676
DO - 10.1111/trf.15676
M3 - Article
C2 - 32034925
SN - 0041-1132
VL - 60
SP - 544
EP - 552
JO - Transfusion
JF - Transfusion
IS - 3
ER -