TY - JOUR
T1 - Variability in the Reporting of Baseline Characteristics, Treatment, and Outcomes in Esophageal Atresia Publications
T2 - A Systematic Review
AU - Teunissen, Nadine
AU - Brendel, Julia
AU - Eaton, Simon
AU - Hall, Nigel
AU - Thursfield, Rebecca
AU - van Heurn, Ernest L. W.
AU - Ure, Benno
AU - Wijnen, Rene
N1 - Funding Information:
Funding None. Acknowledgements This article is supported by ERNICA. The authors would like to thank the European Pediatric Surgical Audit group (EPSA|ERNICA Registry) for scientific input. Additionally, the authors wish to thank Sabrina T.G. Meertens-Gunput from the Erasmus MC Medical Library for developing and updating the search strategies. And thanks to Ko Hagoort for editing the manuscript. S.E. acknowledges support from the National Institute of Health Research Biomedical Research Centre at Great Ormond Street Hospital.
Funding Information:
The EPSA|ERNICA Registry was funded by the European Commission in the 3rd Health Program [HP-PJ-2019].
Funding Information:
This article is supported by ERNICA. The authors would like to thank the European Pediatric Surgical Audit group (EPSA|ERNICA Registry) for scientific input. Additionally, the authors wish to thank Sabrina T.G. Meertens-Gunput from the Erasmus MC Medical Library for developing and updating the search strategies. And thanks to Ko Hagoort for editing the manuscript. S.E. acknowledges support from the National Institute of Health Research Biomedical Research Centre at Great Ormond Street Hospital.
Publisher Copyright:
© 2021. Thieme. All rights reserved.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Introduction As survival rates of infants born with esophageal atresia (EA) have improved considerably, research interests are shifting from viability to morbidity and longer-term outcomes. This review aims to identify all parameters studied in recent EA research and determine variability in their reporting, utilization, and definition. Materials and Methods Following PRISMA guidelines, we performed a systematic review of literature regarding the main EA care process, published between 2015 and 2021, combining the search term esophageal atresia with morbidity, mortality, survival, outcome, or complication. Described outcomes were extracted from included publications, along with study and baseline characteristics. Results From 209 publications that met the inclusion criteria, 731 studied parameters were extracted and categorized into patient characteristics (n = 128), treatment and care process characteristics (n = 338), and outcomes (n = 265). Ninety-two of these were reported in more than 5% of included publications. Most frequently reported characteristics were sex (85%), EA type (74%), and repair type (60%). Most frequently reported outcomes were anastomotic stricture (72%), anastomotic leakage (68%), and mortality (66%). Conclusion This study demonstrates considerable heterogeneity of studied parameters in EA research, emphasizing the need for standardized reporting to compare results of EA research. Additionally, the identified items may help develop an informed, evidence-based consensus on outcome measurement in esophageal atresia research and standardized data collection in registries or clinical audits, thereby enabling benchmarking and comparing care between centers, regions, and countries.
AB - Introduction As survival rates of infants born with esophageal atresia (EA) have improved considerably, research interests are shifting from viability to morbidity and longer-term outcomes. This review aims to identify all parameters studied in recent EA research and determine variability in their reporting, utilization, and definition. Materials and Methods Following PRISMA guidelines, we performed a systematic review of literature regarding the main EA care process, published between 2015 and 2021, combining the search term esophageal atresia with morbidity, mortality, survival, outcome, or complication. Described outcomes were extracted from included publications, along with study and baseline characteristics. Results From 209 publications that met the inclusion criteria, 731 studied parameters were extracted and categorized into patient characteristics (n = 128), treatment and care process characteristics (n = 338), and outcomes (n = 265). Ninety-two of these were reported in more than 5% of included publications. Most frequently reported characteristics were sex (85%), EA type (74%), and repair type (60%). Most frequently reported outcomes were anastomotic stricture (72%), anastomotic leakage (68%), and mortality (66%). Conclusion This study demonstrates considerable heterogeneity of studied parameters in EA research, emphasizing the need for standardized reporting to compare results of EA research. Additionally, the identified items may help develop an informed, evidence-based consensus on outcome measurement in esophageal atresia research and standardized data collection in registries or clinical audits, thereby enabling benchmarking and comparing care between centers, regions, and countries.
KW - characteristics
KW - esophageal atresia
KW - outcome
UR - https://www.scopus.com/pages/publications/85150666027
U2 - 10.1055/s-0042-1758828
DO - 10.1055/s-0042-1758828
M3 - Review article
C2 - 36796427
SN - 0939-7248
VL - 33
SP - 129
EP - 137
JO - European journal of pediatric surgery
JF - European journal of pediatric surgery
IS - 2
ER -