Unveiling Cancer Complexity: Phospho-proteomics for biomarker and drug target discovery

Based on molecular profiling, tumours may be effectively targeted by a multi-targeting low-dose drug combination approach. For PDAC patients, specifically, current treatments are limited in terms of efficacy and toxicity. Thus, this thesis aims to provide tools and alternatives to non-tailored treatments by studying the two most functional layers of tumours: the proteome and the phosphoproteome, and to come up with potential biomarkers and guide effective targeting strategies. In this context, vitamin C anti-cancer agent potential is investigated in this and other cancer types for the discovery of predictive markers.