Unmet Needs and Perspectives in Oral Cancer Prevention

Jebrane Bouaoud; Paolo Bossi; Moshe Elkabets; Sandra Schmitz; L. on C. van Kempen; Pierre Martinez; Sankar Jagadeeshan; Ingrid Breuskin; Gerwin J. Puppels; Caroline Hoffmann; Keith D. Hunter; Christian Simon; Jean-Pascal Machiels; Vincent Grégoire; Chloé Bertolus; Ruud H. Brakenhoff; Senada Koljenović; Pierre Saintigny

doi:10.3390/cancers14071815

Unmet Needs and Perspectives in Oral Cancer Prevention

Jebrane Bouaoud^*
, Paolo Bossi
, Moshe Elkabets
, Sandra Schmitz
, L. on C. van Kempen
, Pierre Martinez
, Sankar Jagadeeshan
, Ingrid Breuskin
, Gerwin J. Puppels
, Caroline Hoffmann
, Keith D. Hunter
, Christian Simon
, Jean-Pascal Machiels
, Vincent Grégoire
, Chloé Bertolus
, Ruud H. Brakenhoff
, Senada Koljenović
, Pierre Saintigny^*

^*Corresponding author for this work

Universite Claude Bernard Lyon 1
Sorbonne Université
Brescia Civil Hospital
University of Brescia
Ben-Gurion University of the Negev
Université catholique de Louvain
University of Groningen
Institut Gustave Roussy
Erasmus University Rotterdam
Université PSL
University of Sheffield
Centre Hospitalier Universitaire Vaudois

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

Original language	English
Article number	1815
Journal	Cancers
Volume	14
Issue number	7
DOIs	https://doi.org/10.3390/cancers14071815
Publication status	Published - 1 Apr 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diagnosis
oral cancer
oral potentially malignant disorders
oral preneoplasia
prevention

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Unmet-needs-and-perspectives-in-oral-cancer-prevention.pdfFinal published version, 364 KBLicence: CC BY

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Bouaoud, J., Bossi, P., Elkabets, M., Schmitz, S., van Kempen, L. O. C., Martinez, P., Jagadeeshan, S., Breuskin, I., Puppels, G. J., Hoffmann, C., Hunter, K. D., Simon, C., Machiels, J.-P., Grégoire, V., Bertolus, C., Brakenhoff, R. H., Koljenović, S., & Saintigny, P. (2022). Unmet Needs and Perspectives in Oral Cancer Prevention. Cancers, 14(7), Article 1815. https://doi.org/10.3390/cancers14071815

@article{8cf08f87283042d39c4fe04606b68d7a,

title = "Unmet Needs and Perspectives in Oral Cancer Prevention",

abstract = "Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50\%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.",

keywords = "diagnosis, oral cancer, oral potentially malignant disorders, oral preneoplasia, prevention",

author = "Jebrane Bouaoud and Paolo Bossi and Moshe Elkabets and Sandra Schmitz and \{van Kempen\}, \{L. on C.\} and Pierre Martinez and Sankar Jagadeeshan and Ingrid Breuskin and Puppels, \{Gerwin J.\} and Caroline Hoffmann and Hunter, \{Keith D.\} and Christian Simon and Jean-Pascal Machiels and Vincent Gr{\'e}goire and Chlo{\'e} Bertolus and Brakenhoff, \{Ruud H.\} and Senada Koljenovi{\'c} and Pierre Saintigny",

note = "Funding Information: This research was funded by the following grant: ITMO Cancer 2020, “Formation {\`a} la Recherche Fondamentale et Translationnelle en Canc{\'e}rologie” (JB); CLARA 2020 “Soutien {\`a} la mobilit{\'e} des jeunes chercheurs en oncologie, [N° CVPPRCAN000198]” (JB); Fondation de France 2020 “Aide {\`a} la mobilit{\'e} international de m{\'e}decins et pharmaciens, [N° 00112162]” (JB); Ligue contre le Cancer 2020 (PS); INCa SIRIC-LYriCAN INCa-DGOS-Inserm\_12563” (PS); R{\'e}gion Auvergne-Rh{\^o}ne-Alpes “AAP Amor{\c c}age Europe 2021” [n°21 018082 01 6 22472] (PS); “INCa [n°2021-160-AAP PREV-BIO21-008]–Projet ISEBIO” (PS); “AIRC IG [nr 21740]” (PB). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = apr,

day = "1",

doi = "10.3390/cancers14071815",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

Bouaoud, J, Bossi, P, Elkabets, M, Schmitz, S, van Kempen, LOC, Martinez, P, Jagadeeshan, S, Breuskin, I, Puppels, GJ, Hoffmann, C, Hunter, KD, Simon, C, Machiels, J-P, Grégoire, V, Bertolus, C, Brakenhoff, RH, Koljenović, S & Saintigny, P 2022, 'Unmet Needs and Perspectives in Oral Cancer Prevention', Cancers, vol. 14, no. 7, 1815. https://doi.org/10.3390/cancers14071815

TY - JOUR

T1 - Unmet Needs and Perspectives in Oral Cancer Prevention

AU - Bouaoud, Jebrane

AU - Bossi, Paolo

AU - Elkabets, Moshe

AU - Schmitz, Sandra

AU - van Kempen, L. on C.

AU - Martinez, Pierre

AU - Jagadeeshan, Sankar

AU - Breuskin, Ingrid

AU - Puppels, Gerwin J.

AU - Hoffmann, Caroline

AU - Hunter, Keith D.

AU - Simon, Christian

AU - Machiels, Jean-Pascal

AU - Grégoire, Vincent

AU - Bertolus, Chloé

AU - Brakenhoff, Ruud H.

AU - Koljenović, Senada

AU - Saintigny, Pierre

N1 - Funding Information: This research was funded by the following grant: ITMO Cancer 2020, “Formation à la Recherche Fondamentale et Translationnelle en Cancérologie” (JB); CLARA 2020 “Soutien à la mobilité des jeunes chercheurs en oncologie, [N° CVPPRCAN000198]” (JB); Fondation de France 2020 “Aide à la mobilité international de médecins et pharmaciens, [N° 00112162]” (JB); Ligue contre le Cancer 2020 (PS); INCa SIRIC-LYriCAN INCa-DGOS-Inserm_12563” (PS); Région Auvergne-Rhône-Alpes “AAP Amorçage Europe 2021” [n°21 018082 01 6 22472] (PS); “INCa [n°2021-160-AAP PREV-BIO21-008]–Projet ISEBIO” (PS); “AIRC IG [nr 21740]” (PB). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

AB - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

KW - diagnosis

KW - oral cancer

KW - oral potentially malignant disorders

KW - oral preneoplasia

KW - prevention

UR - https://www.scopus.com/pages/publications/85127417133

U2 - 10.3390/cancers14071815

DO - 10.3390/cancers14071815

M3 - Review article

C2 - 35406587

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 7

M1 - 1815

ER -

Unmet Needs and Perspectives in Oral Cancer Prevention

Abstract

UN SDGs

Keywords

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