Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome

Kazimierz Groen; Febe Smits; Kazem Nasserinejad; Mark-David Levin; Josien C. Regelink; Gert-Jan Timmers; Esther G. M. de Waal; Matthijs Westerman; Gerjo A. Velders; Koen de Heer; Rineke B. L. Leys; Roel J. W. van Kampen; Claudia A. M. Stege; Maarten R. Seefat; Inger S. Nijhof; Ellen van der Spek; Saskia K. Klein; Niels W. C. J. van de Donk; Paula F. Ypma; Sonja Zweegman

doi:10.1002/hem3.70268

Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome

Kazimierz Groen
, Febe Smits
, Kazem Nasserinejad
, Mark-David Levin
, Josien C. Regelink
, Gert-Jan Timmers
, Esther G. M. de Waal
, Matthijs Westerman
, Gerjo A. Velders
, Koen de Heer
, Rineke B. L. Leys
, Roel J. W. van Kampen
, Claudia A. M. Stege
, Maarten R. Seefat
, Inger S. Nijhof
, Ellen van der Spek
, Saskia K. Klein
, Niels W. C. J. van de Donk
, Paula F. Ypma
, Sonja Zweegman^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Original language	English
Article number	e70268
Journal	HemaSphere
Volume	9
Issue number	12
DOIs	https://doi.org/10.1002/hem3.70268
Publication status	Published - 1 Dec 2025

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Groen, K., Smits, F., Nasserinejad, K., Levin, M.-D., Regelink, J. C., Timmers, G.-J., de Waal, E. G. M., Westerman, M., Velders, G. A., de Heer, K., Leys, R. B. L., van Kampen, R. J. W., Stege, C. A. M., Seefat, M. R., Nijhof, I. S., van der Spek, E., Klein, S. K., van de Donk, N. W. C. J., Ypma, P. F., & Zweegman, S. (2025). Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome. HemaSphere, 9(12), Article e70268. https://doi.org/10.1002/hem3.70268

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title = "Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome",

author = "Kazimierz Groen and Febe Smits and Kazem Nasserinejad and Mark-David Levin and Regelink, \{Josien C.\} and Gert-Jan Timmers and \{de Waal\}, \{Esther G. M.\} and Matthijs Westerman and Velders, \{Gerjo A.\} and \{de Heer\}, Koen and Leys, \{Rineke B. L.\} and \{van Kampen\}, \{Roel J. W.\} and Stege, \{Claudia A. M.\} and Seefat, \{Maarten R.\} and Nijhof, \{Inger S.\} and \{van der Spek\}, Ellen and Klein, \{Saskia K.\} and \{van de Donk\}, \{Niels W. C. J.\} and Ypma, \{Paula F.\} and Sonja Zweegman",

year = "2025",

month = dec,

day = "1",

doi = "10.1002/hem3.70268",

language = "English",

volume = "9",

journal = "HemaSphere",

issn = "2572-9241",

publisher = "John Wiley and Sons Inc.",

number = "12",

}

Groen, K , Smits, F, Nasserinejad, K, Levin, M-D, Regelink, JC, Timmers, G-J, de Waal, EGM, Westerman, M, Velders, GA, de Heer, K, Leys, RBL, van Kampen, RJW, Stege, CAM, Seefat, MR , Nijhof, IS, van der Spek, E, Klein, SK, van de Donk, NWCJ, Ypma, PF & Zweegman, S 2025, 'Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome', HemaSphere, vol. 9, no. 12, e70268. https://doi.org/10.1002/hem3.70268

TY - JOUR

T1 - Uncovering the ultra-frail

T2 - A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome

AU - Groen, Kazimierz

AU - Smits, Febe

AU - Nasserinejad, Kazem

AU - Levin, Mark-David

AU - Regelink, Josien C.

AU - Timmers, Gert-Jan

AU - de Waal, Esther G. M.

AU - Westerman, Matthijs

AU - Velders, Gerjo A.

AU - de Heer, Koen

AU - Leys, Rineke B. L.

AU - van Kampen, Roel J. W.

AU - Stege, Claudia A. M.

AU - Seefat, Maarten R.

AU - Nijhof, Inger S.

AU - van der Spek, Ellen

AU - Klein, Saskia K.

AU - van de Donk, Niels W. C. J.

AU - Ypma, Paula F.

AU - Zweegman, Sonja

PY - 2025/12/1

Y1 - 2025/12/1

UR - https://www.scopus.com/pages/publications/105024136484

U2 - 10.1002/hem3.70268

DO - 10.1002/hem3.70268

M3 - Comment/Letter to the editor

C2 - 41368074

SN - 2572-9241

VL - 9

JO - HemaSphere

JF - HemaSphere

IS - 12

M1 - e70268

ER -

Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome

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