TY - JOUR
T1 - Two-minute k-space and time–accelerated aortic fourdimensional flow MRI
T2 - Dual-center study of feasibility and impact on velocity and wall shear stress quantification
AU - Bollache, Emilie
AU - Knott, Kristopher D.
AU - Jarvis, Kelly
AU - Boubertakh, Redha
AU - Dolan, Ryan Scott
AU - Camaioni, Claudia
AU - Collins, Louise
AU - Scully, Paul
AU - Rabin, Sydney
AU - Treibel, Thomas
AU - Carr, James C.
AU - Van Ooij, Pim
AU - Collins, Jeremy D.
AU - Geiger, Julia
AU - Moon, James C.
AU - Barker, Alex J.
AU - Petersen, Steffen E.
AU - Markl, Michael
N1 - Funding Information:
K.J. supported by National Heart, Lung, and Blood Institute (T32HL134633). P.S. supported by British Heart Foundation (FS/17/34/32901). Supported by the National Institutes of Health grants (R01HL115828, K25HL119608) and the American Heart Association Midwest Affiliate grant (16POST27250158). This work partly used the Barts BioResource, which forms part of the research areas contributing to the translational research portfolio of the Biomedical Research Centre at Barts, which is supported and funded by the National Institute for Health Research.
Publisher Copyright:
© RSNA, 2019.
PY - 2019/6
Y1 - 2019/6
N2 - Purpose To investigate the two-center feasibility of highly k-space and time (k-t)–accelerated 2-minute aortic four-dimensional (4D) flow MRI and to evaluate its performance for the quantification of velocities and wall shear stress (WSS). Materials and Methods This cross-sectional study prospectively included 68 participants (center 1, 11 healthy volunteers [mean age ± standard deviation, 61 years ± 15] and 16 patients with aortic disease [mean age, 60 years ± 10]; center 2, 14 healthy volunteers [mean age, 38 years ± 13] and 27 patients with aortic or cardiac disease [mean age, 78 years ± 18]). Each participant underwent highly accelerated 4D flow MRI (k-t acceleration, acceleration factor of 5) of the thoracic aorta. For comparison, conventional 4D flow MRI (acceleration factor of 2) was acquired in the participants at center 1 (n = 27). Regional aortic peak systolic velocities and three-dimensional WSS were quantified. Results k-t–accelerated scan times (center 1, 2:03 minutes ± 0:29; center 2, 2:06 minutes ± 0:20) were significantly reduced compared with conventional 4D flow MRI (center 1, 12:38 minutes ± 2:25; P <.0001). Overall good agreement was found between the two techniques (absolute differences ≤15%), but proximal aortic WSS was significantly underestimated in patients by using k-t–accelerated 4D flow when compared with conventional 4D flow (P ≤.03). k-t–accelerated 4D flow MRI was reproducible (intra- and interobserver intraclass correlation coefficient ≥0.98) and identified significantly increased peak velocities and WSS in patients with stenotic (P ≤.003) or bicuspid (P ≤.04) aortic valves compared with healthy volunteers. In addition, k-t–accelerated 4D flow MRI–derived velocities and WSS were inversely related to age (r ≥−0.53; P ≤.03) over all healthy volunteers. Conclusion k-t–accelerated aortic 4D flow MRI providing 2-minute scan times was feasible and reproducible at two centers. Although consistent healthy aging- and disease-related changes in aortic hemodynamics were observed, care should be taken when considering WSS, which can be underestimated in patients.
AB - Purpose To investigate the two-center feasibility of highly k-space and time (k-t)–accelerated 2-minute aortic four-dimensional (4D) flow MRI and to evaluate its performance for the quantification of velocities and wall shear stress (WSS). Materials and Methods This cross-sectional study prospectively included 68 participants (center 1, 11 healthy volunteers [mean age ± standard deviation, 61 years ± 15] and 16 patients with aortic disease [mean age, 60 years ± 10]; center 2, 14 healthy volunteers [mean age, 38 years ± 13] and 27 patients with aortic or cardiac disease [mean age, 78 years ± 18]). Each participant underwent highly accelerated 4D flow MRI (k-t acceleration, acceleration factor of 5) of the thoracic aorta. For comparison, conventional 4D flow MRI (acceleration factor of 2) was acquired in the participants at center 1 (n = 27). Regional aortic peak systolic velocities and three-dimensional WSS were quantified. Results k-t–accelerated scan times (center 1, 2:03 minutes ± 0:29; center 2, 2:06 minutes ± 0:20) were significantly reduced compared with conventional 4D flow MRI (center 1, 12:38 minutes ± 2:25; P <.0001). Overall good agreement was found between the two techniques (absolute differences ≤15%), but proximal aortic WSS was significantly underestimated in patients by using k-t–accelerated 4D flow when compared with conventional 4D flow (P ≤.03). k-t–accelerated 4D flow MRI was reproducible (intra- and interobserver intraclass correlation coefficient ≥0.98) and identified significantly increased peak velocities and WSS in patients with stenotic (P ≤.003) or bicuspid (P ≤.04) aortic valves compared with healthy volunteers. In addition, k-t–accelerated 4D flow MRI–derived velocities and WSS were inversely related to age (r ≥−0.53; P ≤.03) over all healthy volunteers. Conclusion k-t–accelerated aortic 4D flow MRI providing 2-minute scan times was feasible and reproducible at two centers. Although consistent healthy aging- and disease-related changes in aortic hemodynamics were observed, care should be taken when considering WSS, which can be underestimated in patients.
UR - https://www.scopus.com/pages/publications/85089945179
U2 - 10.1148/ryct.2019180008
DO - 10.1148/ryct.2019180008
M3 - Article
VL - 1
JO - Radiology: Cardiothoracic Imaging
JF - Radiology: Cardiothoracic Imaging
IS - 2
M1 - e180008
ER -