Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie

Rosemarijn H. Ettema; Dennie Meijer; Maarten L. Donswijk; Yves J. L. Bodar; Pim J. van Leeuwen; Henk G. van der Poel; Wouter V. Vogel; Jakko A. Nieuwenhuijzen; N. Harry Hendrikse; Daniela E. Oprea-Lager; André N. Vis

doi:10.1007/s13629-021-00320-3

Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie

Rosemarijn H. Ettema
, Dennie Meijer^*
, Maarten L. Donswijk
, Yves J. L. Bodar
, Pim J. van Leeuwen
, Henk G. van der Poel
, Wouter V. Vogel
, Jakko A. Nieuwenhuijzen
, N. Harry Hendrikse
, Daniela E. Oprea-Lager
, André N. Vis

^*Corresponding author for this work

Amsterdam UMC - University of Amsterdam
Netherlands Association of Comprehensive Cancer Centres
Antoni van Leeuwenhoek Hospital
Amsterdam Universitair Medische Centra

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Abstract

The aim of this study was to determine the role of PSMA-PET/CT imaging in patients who experience biochemical persistence (BCP) after robot-assisted laparoscopic radical prostatectomy (RARP). 150 patients with BCP after RARP who underwent radiolabeled PSMA-PET/CT imaging were evaluated. A multivariable logistic regression analysis was performed to identify predictors for the detection of metastases outside the prostatic fossa (≥ miN1) on PSMA-PET/CT. Results: In total, 89/150 patients (59%) had ≥ miN1 on PSMA-PET/CT at BCP. On multivariable analysis, higher PSA-values after RARP (p = 0.004) and positive pathological lymph node status (p = 0.006) were independent predictors for ≥ miN1. In presence of BCP, a high proportion of patients had ≥ miN1 disease, indicated by PSMA-PET/CT. Higher PSA-levels after RARP and positive pathological lymph node status were significantly associated with metastases outside the prostatic fossa. In conclusion, in patients with BCP, PSMA-PET/CT imaging is warranted to guide (salvage) treatment strategies.

Original language	Dutch
Pages (from-to)	54-61
Number of pages	8
Journal	Tijdschrift voor urologie
Volume	11
Issue number	4
DOIs	https://doi.org/10.1007/s13629-021-00320-3
Publication status	Published - 1 Jul 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biochemical persistence
prostate cancer
PSMA-PET/CT imaging

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Tumorlokalisaties-op-psma-petct-bij-patienten-met-een-persisterend-meetbaar-psa-na-een-radicale-prostatectomie.pdfFinal published version, 428 KBLicence: CC BY

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Ettema, R. H., Meijer, D., Donswijk, M. L., Bodar, Y. J. L., van Leeuwen, P. J., van der Poel, H. G., Vogel, W. V., Nieuwenhuijzen, J. A., Hendrikse, N. H., Oprea-Lager, D. E., & Vis, A. N. (2021). Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie. Tijdschrift voor urologie, 11(4), 54-61. https://doi.org/10.1007/s13629-021-00320-3

@article{a200b601429c4c28a96de52aa625f5d0,

title = "Tumorlokalisaties op PSMA-PET/CT bij pati{\"e}nten met een persisterend meetbaar PSA na een radicale prostatectomie",

abstract = "The aim of this study was to determine the role of PSMA-PET/CT imaging in patients who experience biochemical persistence (BCP) after robot-assisted laparoscopic radical prostatectomy (RARP). 150 patients with BCP after RARP who underwent radiolabeled PSMA-PET/CT imaging were evaluated. A multivariable logistic regression analysis was performed to identify predictors for the detection of metastases outside the prostatic fossa (≥ miN1) on PSMA-PET/CT. Results: In total, 89/150 patients (59\%) had ≥ miN1 on PSMA-PET/CT at BCP. On multivariable analysis, higher PSA-values after RARP (p = 0.004) and positive pathological lymph node status (p = 0.006) were independent predictors for ≥ miN1. In presence of BCP, a high proportion of patients had ≥ miN1 disease, indicated by PSMA-PET/CT. Higher PSA-levels after RARP and positive pathological lymph node status were significantly associated with metastases outside the prostatic fossa. In conclusion, in patients with BCP, PSMA-PET/CT imaging is warranted to guide (salvage) treatment strategies.",

keywords = "biochemical persistence, prostate cancer, PSMA-PET/CT imaging",

author = "Ettema, \{Rosemarijn H.\} and Dennie Meijer and Donswijk, \{Maarten L.\} and Bodar, \{Yves J. L.\} and \{van Leeuwen\}, \{Pim J.\} and \{van der Poel\}, \{Henk G.\} and Vogel, \{Wouter V.\} and Nieuwenhuijzen, \{Jakko A.\} and Hendrikse, \{N. Harry\} and Oprea-Lager, \{Daniela E.\} and Vis, \{Andr{\'e} N.\}",

year = "2021",

month = jul,

day = "1",

doi = "10.1007/s13629-021-00320-3",

language = "Dutch",

volume = "11",

pages = "54--61",

journal = "Tijdschrift voor urologie",

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number = "4",

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Ettema, RH, Meijer, D, Donswijk, ML, Bodar, YJL, van Leeuwen, PJ, van der Poel, HG, Vogel, WV, Nieuwenhuijzen, JA, Hendrikse, NH, Oprea-Lager, DE & Vis, AN 2021, 'Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie', Tijdschrift voor urologie, vol. 11, no. 4, pp. 54-61. https://doi.org/10.1007/s13629-021-00320-3

TY - JOUR

T1 - Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie

AU - Ettema, Rosemarijn H.

AU - Meijer, Dennie

AU - Donswijk, Maarten L.

AU - Bodar, Yves J. L.

AU - van Leeuwen, Pim J.

AU - van der Poel, Henk G.

AU - Vogel, Wouter V.

AU - Nieuwenhuijzen, Jakko A.

AU - Hendrikse, N. Harry

AU - Oprea-Lager, Daniela E.

AU - Vis, André N.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - The aim of this study was to determine the role of PSMA-PET/CT imaging in patients who experience biochemical persistence (BCP) after robot-assisted laparoscopic radical prostatectomy (RARP). 150 patients with BCP after RARP who underwent radiolabeled PSMA-PET/CT imaging were evaluated. A multivariable logistic regression analysis was performed to identify predictors for the detection of metastases outside the prostatic fossa (≥ miN1) on PSMA-PET/CT. Results: In total, 89/150 patients (59%) had ≥ miN1 on PSMA-PET/CT at BCP. On multivariable analysis, higher PSA-values after RARP (p = 0.004) and positive pathological lymph node status (p = 0.006) were independent predictors for ≥ miN1. In presence of BCP, a high proportion of patients had ≥ miN1 disease, indicated by PSMA-PET/CT. Higher PSA-levels after RARP and positive pathological lymph node status were significantly associated with metastases outside the prostatic fossa. In conclusion, in patients with BCP, PSMA-PET/CT imaging is warranted to guide (salvage) treatment strategies.

AB - The aim of this study was to determine the role of PSMA-PET/CT imaging in patients who experience biochemical persistence (BCP) after robot-assisted laparoscopic radical prostatectomy (RARP). 150 patients with BCP after RARP who underwent radiolabeled PSMA-PET/CT imaging were evaluated. A multivariable logistic regression analysis was performed to identify predictors for the detection of metastases outside the prostatic fossa (≥ miN1) on PSMA-PET/CT. Results: In total, 89/150 patients (59%) had ≥ miN1 on PSMA-PET/CT at BCP. On multivariable analysis, higher PSA-values after RARP (p = 0.004) and positive pathological lymph node status (p = 0.006) were independent predictors for ≥ miN1. In presence of BCP, a high proportion of patients had ≥ miN1 disease, indicated by PSMA-PET/CT. Higher PSA-levels after RARP and positive pathological lymph node status were significantly associated with metastases outside the prostatic fossa. In conclusion, in patients with BCP, PSMA-PET/CT imaging is warranted to guide (salvage) treatment strategies.

KW - biochemical persistence

KW - prostate cancer

KW - PSMA-PET/CT imaging

UR - https://www.scopus.com/pages/publications/85102312839

U2 - 10.1007/s13629-021-00320-3

DO - 10.1007/s13629-021-00320-3

M3 - Article

SN - 2211-3037

VL - 11

SP - 54

EP - 61

JO - Tijdschrift voor urologie

JF - Tijdschrift voor urologie

IS - 4

ER -

Tumorlokalisaties op PSMA-PET/CT bij patiënten met een persisterend meetbaar PSA na een radicale prostatectomie

Abstract

UN SDGs

Keywords

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