Tumor-related epilepsy in glioma: A multidisciplinary overview

Roberto Michelucci; Giada Pauletto; Antonio Silvani; Elena Pasini; Tamara Ius; Matteo Martinoni; Carlo Alberto Castioni; Andrea Salmaggi; Sofia Asioli; Marta Maschio; Giuseppe Minniti; Enrico Franceschi; Flavio Villani; Roberta Rudà; Eleonora Aronica; the Italian Multidisciplinary Group for Tumor Epilepsy

doi:10.1111/epi.18523

Tumor-related epilepsy in glioma: A multidisciplinary overview

Roberto Michelucci^*
, Giada Pauletto
, Antonio Silvani
, Elena Pasini
, Tamara Ius
, Matteo Martinoni
, Carlo Alberto Castioni
, Andrea Salmaggi
, Sofia Asioli
, Marta Maschio
, Giuseppe Minniti
, Enrico Franceschi
, Flavio Villani
, Roberta Rudà
, Eleonora Aronica
, the Italian Multidisciplinary Group for Tumor Epilepsy

^*Corresponding author for this work

IRCCS Istituto delle Scienze Neurologiche di Bologna
Policlinico Universitario, Udine
IRCCS Fondazione Istituto Neurologico Carlo Besta - Milano
University of Padua
ASST Lecco
University of Bologna
IRCCS Istituti fisioterapici ospitalieri - Istituto Regina Elena
University of Rome La Sapienza
Ospedale Bellaria
IRCCS San Martino Polyclinic Hospital
University of Turin
University of Amsterdam

Research output: Contribution to journal › Review article › Academic › peer-review

70 Downloads (Pure)

Abstract

Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.

Original language	English
Pages (from-to)	3621-3641
Number of pages	21
Journal	Epilepsia
Volume	66
Issue number	10
Early online date	2025
DOIs	https://doi.org/10.1111/epi.18523
Publication status	Published - Oct 2025

Keywords

antiseizure medications
cerebral tumors
chemotherapy
epilepsy
epilepsy surgery
radiotherapy

Access to Document

10.1111/epi.18523

Tumor-related-epilepsy-in-glioma.pdfFinal published version, 2.42 MBLicence: CC BY

Cite this

Michelucci, R., Pauletto, G., Silvani, A., Pasini, E., Ius, T., Martinoni, M., Castioni, C. A., Salmaggi, A., Asioli, S., Maschio, M., Minniti, G., Franceschi, E., Villani, F., Rudà, R., Aronica, E., & the Italian Multidisciplinary Group for Tumor Epilepsy (2025). Tumor-related epilepsy in glioma: A multidisciplinary overview. Epilepsia, 66(10), 3621-3641. https://doi.org/10.1111/epi.18523

@article{73fda35abb4b4b26866c3a514eca2a35,

title = "Tumor-related epilepsy in glioma: A multidisciplinary overview",

abstract = "Seizures are a common and challenging symptom in brain tumors, affecting approximately 60\% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.",

keywords = "antiseizure medications, cerebral tumors, chemotherapy, epilepsy, epilepsy surgery, radiotherapy",

author = "Roberto Michelucci and Giada Pauletto and Antonio Silvani and Elena Pasini and Tamara Ius and Matteo Martinoni and Castioni, \{Carlo Alberto\} and Andrea Salmaggi and Sofia Asioli and Marta Maschio and Giuseppe Minniti and Enrico Franceschi and Flavio Villani and Roberta Rud{\`a} and Eleonora Aronica and \{the Italian Multidisciplinary Group for Tumor Epilepsy\} and Paolo Vitali and Damiano Balestrini and Elisa D{\textquoteright}Angelo and Lorenzo Bello and Marco Rossi and Marta Padovan and Giallonardo, \{Anna Teresa\} and \{di Bonaventura\}, Carlo and Francesco Toni and \{la Neve\}, Angela and Simona Rizzato and Matteo Pugnaghi and Marco Vindigni and Carmelo Sturiale",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.",

year = "2025",

month = oct,

doi = "10.1111/epi.18523",

language = "English",

volume = "66",

pages = "3621--3641",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Wiley Blackwell",

number = "10",

}

Michelucci, R, Pauletto, G, Silvani, A, Pasini, E, Ius, T, Martinoni, M, Castioni, CA, Salmaggi, A, Asioli, S, Maschio, M, Minniti, G, Franceschi, E, Villani, F, Rudà, R, Aronica, E & the Italian Multidisciplinary Group for Tumor Epilepsy 2025, 'Tumor-related epilepsy in glioma: A multidisciplinary overview', Epilepsia, vol. 66, no. 10, pp. 3621-3641. https://doi.org/10.1111/epi.18523

TY - JOUR

T1 - Tumor-related epilepsy in glioma

T2 - A multidisciplinary overview

AU - Michelucci, Roberto

AU - Pauletto, Giada

AU - Silvani, Antonio

AU - Pasini, Elena

AU - Ius, Tamara

AU - Martinoni, Matteo

AU - Castioni, Carlo Alberto

AU - Salmaggi, Andrea

AU - Asioli, Sofia

AU - Maschio, Marta

AU - Minniti, Giuseppe

AU - Franceschi, Enrico

AU - Villani, Flavio

AU - Rudà, Roberta

AU - Aronica, Eleonora

AU - the Italian Multidisciplinary Group for Tumor Epilepsy

AU - Vitali, Paolo

AU - Balestrini, Damiano

AU - D’Angelo, Elisa

AU - Bello, Lorenzo

AU - Rossi, Marco

AU - Padovan, Marta

AU - Giallonardo, Anna Teresa

AU - di Bonaventura, Carlo

AU - Toni, Francesco

AU - la Neve, Angela

AU - Rizzato, Simona

AU - Pugnaghi, Matteo

AU - Vindigni, Marco

AU - Sturiale, Carmelo

PY - 2025/10

Y1 - 2025/10

N2 - Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.

AB - Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.

KW - antiseizure medications

KW - cerebral tumors

KW - chemotherapy

KW - epilepsy

KW - epilepsy surgery

KW - radiotherapy

UR - https://www.scopus.com/pages/publications/105011142935

U2 - 10.1111/epi.18523

DO - 10.1111/epi.18523

M3 - Review article

C2 - 40616791

SN - 0013-9580

VL - 66

SP - 3621

EP - 3641

JO - Epilepsia

JF - Epilepsia

IS - 10

ER -

Tumor-related epilepsy in glioma: A multidisciplinary overview

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this