Transient impairment of the adaptive response to fasting in FXR-deficient mice

Bertrand Cariou; Kirsten Van Harmelen; Daniel Duran-Sandoval; Theo Van Dijk; Aldo Grefhorst; Emmanuel Bouchaert; Jean Charles Fruchart; Frank J. Gonzalez; Folkert Kuipers; Bart Staels

doi:10.1016/j.febslet.2005.06.033

Transient impairment of the adaptive response to fasting in FXR-deficient mice

Bertrand Cariou
, Kirsten Van Harmelen
, Daniel Duran-Sandoval
, Theo Van Dijk
, Aldo Grefhorst
, Emmanuel Bouchaert
, Jean Charles Fruchart
, Frank J. Gonzalez
, Folkert Kuipers
, Bart Staels^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR^-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR^-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR^-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR^-/-mice after 6 h of fasting and was decreased in FXR^-/-hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.

Original language	English
Pages (from-to)	4076-4080
Number of pages	5
Journal	FEBS letters
Volume	579
Issue number	19
DOIs	https://doi.org/10.1016/j.febslet.2005.06.033
Publication status	Published - 1 Aug 2005

Keywords

Farnesoid X receptor
Fasting
Gluconeogenesis
PEPCK

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10.1016/j.febslet.2005.06.033

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@article{d24177d797354c1e95d298404ff7f651,

title = "Transient impairment of the adaptive response to fasting in FXR-deficient mice",

abstract = "The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/-mice after 6 h of fasting and was decreased in FXR-/-hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.",

keywords = "Farnesoid X receptor, Fasting, Gluconeogenesis, PEPCK",

author = "Bertrand Cariou and \{Van Harmelen\}, Kirsten and Daniel Duran-Sandoval and \{Van Dijk\}, Theo and Aldo Grefhorst and Emmanuel Bouchaert and Fruchart, \{Jean Charles\} and Gonzalez, \{Frank J.\} and Folkert Kuipers and Bart Staels",

year = "2005",

month = aug,

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doi = "10.1016/j.febslet.2005.06.033",

language = "English",

volume = "579",

pages = "4076--4080",

journal = "FEBS letters",

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number = "19",

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TY - JOUR

T1 - Transient impairment of the adaptive response to fasting in FXR-deficient mice

AU - Cariou, Bertrand

AU - Van Harmelen, Kirsten

AU - Duran-Sandoval, Daniel

AU - Van Dijk, Theo

AU - Grefhorst, Aldo

AU - Bouchaert, Emmanuel

AU - Fruchart, Jean Charles

AU - Gonzalez, Frank J.

AU - Kuipers, Folkert

AU - Staels, Bart

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/-mice after 6 h of fasting and was decreased in FXR-/-hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.

AB - The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/-mice after 6 h of fasting and was decreased in FXR-/-hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.

KW - Farnesoid X receptor

KW - Fasting

KW - Gluconeogenesis

KW - PEPCK

UR - https://www.scopus.com/pages/publications/22544474215

U2 - 10.1016/j.febslet.2005.06.033

DO - 10.1016/j.febslet.2005.06.033

M3 - Article

C2 - 16023103

SN - 0014-5793

VL - 579

SP - 4076

EP - 4080

JO - FEBS letters

JF - FEBS letters

IS - 19

ER -

Transient impairment of the adaptive response to fasting in FXR-deficient mice

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Keywords

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