Thrombophilia in childhood: to test or not to test

C. Heleen van Ommen; Saskia Middeldorp

doi:10.1055/s-0031-1297170

Thrombophilia in childhood: to test or not to test

C. Heleen van Ommen
, Saskia Middeldorp

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Inherited thrombophilia is defined as a genetically determined tendency to develop venous thromboembolism. In children, inherited thrombophilia contributes to the development of pediatric thromboembolic disease. As a consequence, pediatric hematologists are increasingly requested to test thrombophilia in pediatric patients with thrombosis or asymptomatic children from thrombophilic families. This article reviews the benefits and limitations of testing for thrombophilic disorders, for example, factor V Leiden, prothrombin mutation, and deficiencies of antithrombin, protein C, or protein S in childhood

Original language	English
Pages (from-to)	794-801
Journal	Seminars in thrombosis and hemostasis
Volume	37
Issue number	7
DOIs	https://doi.org/10.1055/s-0031-1297170
Publication status	Published - 2011

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10.1055/s-0031-1297170

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abstract = "Inherited thrombophilia is defined as a genetically determined tendency to develop venous thromboembolism. In children, inherited thrombophilia contributes to the development of pediatric thromboembolic disease. As a consequence, pediatric hematologists are increasingly requested to test thrombophilia in pediatric patients with thrombosis or asymptomatic children from thrombophilic families. This article reviews the benefits and limitations of testing for thrombophilic disorders, for example, factor V Leiden, prothrombin mutation, and deficiencies of antithrombin, protein C, or protein S in childhood",

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AB - Inherited thrombophilia is defined as a genetically determined tendency to develop venous thromboembolism. In children, inherited thrombophilia contributes to the development of pediatric thromboembolic disease. As a consequence, pediatric hematologists are increasingly requested to test thrombophilia in pediatric patients with thrombosis or asymptomatic children from thrombophilic families. This article reviews the benefits and limitations of testing for thrombophilic disorders, for example, factor V Leiden, prothrombin mutation, and deficiencies of antithrombin, protein C, or protein S in childhood

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Thrombophilia in childhood: to test or not to test

Abstract

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