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Three-dimensional Surface Imaging for Clinical Decision Making in Pectus Excavatum

  • Jean H. T. Daemen
  • , Nadine A. Coorens
  • , Karel W. E. Hulsewé
  • , Thomas J. J. Maal
  • , Jos G. Maessen
  • , Yvonne L. J. Vissers
  • , Erik R. de Loos*
  • *Corresponding author for this work
  • Department of Internal Medicine, Zuyderland Medical Center, Heerlen, Limburg, The Netherlands
  • Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, University of Maastricht, Maastricht, The Netherlands;
  • Radboud University Medical Center
  • Maastricht UMC+
  • Maastricht University

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

To evaluate pectus excavatum, 3-dimensional surface imaging is a promising radiation-free alternative to computed tomography and plain radiographs. Given that 3-dimensional images concern the external surface, the conventional Haller index, and correction index are not applicable as these are based on internal diameters. Therefore, external equivalents have been introduced for 3-dimensional images. However, cut-off values to help determine surgical candidacy using external indices are lacking. A prospective cohort study was conducted. Consecutive patients referred for suspected pectus excavatum received a computed tomography (≥18 years) or plain radiographs (<18 years). The external Haller index and external correction index were calculated from additionally acquired 3-dimensional images. Cut-off values for the 3-dimensional image derived indices were obtained by receiver-operating characteristic curve analyses, using a conventional Haller index ≥3.25, and computed tomography derived correction index ≥28.0% as indicative for surgery. Sixty-one and 63 patients were included in the computed tomography and radiograph group, respectively. To determine potential surgical candidacy, receiver-operating characteristic analyses found an optimum cut-off of ≥1.83 for the external Haller index in both the computed tomography and radiograph group with a positive predictive value between 0.90 and 0.97 and a negative predictive value between 0.72 and 0.81. The optimal cut-off for the external correction index was ≥15.2% with a positive predictive value of 0.86 and negative predictive value of 0.93. The 3-dimensional image derived external Haller index and external correction index are accurate radiation-free alternatives to facilitate surgical decision-making among patients suspected of pectus excavatum with values of ≥1.83 and ≥15.2% indicative for surgery.

Original languageEnglish
JournalSeminars in thoracic and cardiovascular surgery
Early online date2021
DOIs
Publication statusE-pub ahead of print - 2021

Keywords

  • Computed tomography
  • External Haller index
  • Haller index
  • Pectus excavatum
  • Three-dimensional surface imaging

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