The use of whole blood in a dipstick assay for detection of antibodies to Mycobacterium leprae: A field evaluation

Samira Bührer-Sekula; Maria da Graça Souza Cunha; Willian Antunes Ferreira; Paul R. Klatser

doi:10.1016/S0928-8244(98)00049-2

The use of whole blood in a dipstick assay for detection of antibodies to Mycobacterium leprae: A field evaluation

Samira Bührer-Sekula
, Maria da Graça Souza Cunha
, Willian Antunes Ferreira
, Paul R. Klatser

Royal Tropical Institute
Inst. Dermatologia Venerologia A.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We describe a further simplification of a dipstick assay for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae by using whole blood and evaluated the assay performance in the leprosy endemic area of Amazonas in Brazil. The agreement with the 'gold' standard ELISA was 94.9% (κ value=0.87). This simple assay may be useful to identify those at risk of developing leprosy, for example among contacts of leprosy patients at lower levels in the health services. Copyright (C) 1998 Federation of European Microbiological Societies.

Original language	English
Pages (from-to)	197-201
Journal	FEMS immunology and medical microbiology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/S0928-8244(98)00049-2
Publication status	Published - Jul 1998
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/S0928-8244(98)00049-2

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title = "The use of whole blood in a dipstick assay for detection of antibodies to Mycobacterium leprae: A field evaluation",

abstract = "We describe a further simplification of a dipstick assay for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae by using whole blood and evaluated the assay performance in the leprosy endemic area of Amazonas in Brazil. The agreement with the 'gold' standard ELISA was 94.9\% (κ value=0.87). This simple assay may be useful to identify those at risk of developing leprosy, for example among contacts of leprosy patients at lower levels in the health services. Copyright (C) 1998 Federation of European Microbiological Societies.",

author = "Samira B{\"u}hrer-Sekula and \{da Gra{\c c}a Souza Cunha\}, Maria and Ferreira, \{Willian Antunes\} and Klatser, \{Paul R.\}",

year = "1998",

month = jul,

doi = "10.1016/S0928-8244(98)00049-2",

language = "English",

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AU - Ferreira, Willian Antunes

AU - Klatser, Paul R.

PY - 1998/7

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N2 - We describe a further simplification of a dipstick assay for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae by using whole blood and evaluated the assay performance in the leprosy endemic area of Amazonas in Brazil. The agreement with the 'gold' standard ELISA was 94.9% (κ value=0.87). This simple assay may be useful to identify those at risk of developing leprosy, for example among contacts of leprosy patients at lower levels in the health services. Copyright (C) 1998 Federation of European Microbiological Societies.

AB - We describe a further simplification of a dipstick assay for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae by using whole blood and evaluated the assay performance in the leprosy endemic area of Amazonas in Brazil. The agreement with the 'gold' standard ELISA was 94.9% (κ value=0.87). This simple assay may be useful to identify those at risk of developing leprosy, for example among contacts of leprosy patients at lower levels in the health services. Copyright (C) 1998 Federation of European Microbiological Societies.

UR - https://www.scopus.com/pages/publications/0344474560

UR - https://www.ncbi.nlm.nih.gov/pubmed/9718209

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JO - FEMS immunology and medical microbiology

JF - FEMS immunology and medical microbiology

IS - 3

ER -

The use of whole blood in a dipstick assay for detection of antibodies to Mycobacterium leprae: A field evaluation

Abstract

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