The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

Janneke I. M. van Uhm; Gerard W. M. Visser; Marcel J. van der Schans; Albert A. Geldof; Eric J. H. Meuleman; Jakko A. Nieuwenhuijzen

doi:10.1186/s13550-015-0083-5

The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

Janneke I. M. van Uhm^*
, Gerard W. M. Visser
, Marcel J. van der Schans
, Albert A. Geldof
, Eric J. H. Meuleman
, Jakko A. Nieuwenhuijzen

^*Corresponding author for this work

Amsterdam UMC - Vrije Universiteit Amsterdam
Netherlands Organisation for Applied Scientific Research

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.

Original language	English
Article number	5
Journal	EJNMMI research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/s13550-015-0083-5
Publication status	Published - 2015

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van Uhm, J. I. M., Visser, G. W. M., van der Schans, M. J., Geldof, A. A., Meuleman, E. J. H., & Nieuwenhuijzen, J. A. (2015). The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule. EJNMMI research, 5(1), Article 5. https://doi.org/10.1186/s13550-015-0083-5

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title = "The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule",

abstract = "Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.",

author = "\{van Uhm\}, \{Janneke I. M.\} and Visser, \{Gerard W. M.\} and \{van der Schans\}, \{Marcel J.\} and Geldof, \{Albert A.\} and Meuleman, \{Eric J. H.\} and Nieuwenhuijzen, \{Jakko A.\}",

year = "2015",

doi = "10.1186/s13550-015-0083-5",

language = "English",

volume = "5",

journal = "EJNMMI research",

issn = "2191-219X",

publisher = "Springer Science and Business Media Deutschland GmbH",

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}

The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule. / van Uhm, Janneke I. M.; Visser, Gerard W. M.; van der Schans, Marcel J. et al.
In: EJNMMI research, Vol. 5, No. 1, 5, 2015.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The ultimate radiochemical nightmare

T2 - upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

AU - van Uhm, Janneke I. M.

AU - Visser, Gerard W. M.

AU - van der Schans, Marcel J.

AU - Geldof, Albert A.

AU - Meuleman, Eric J. H.

AU - Nieuwenhuijzen, Jakko A.

PY - 2015

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N2 - Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.

AB - Background: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabelled BoNT-A. In this paper, we report our feasibility study on labelling BoNT-A with high-dose iodine-125 (125I) via IODOGEN-coated BoNT-A method.

UR - https://www.scopus.com/pages/publications/84923354486

U2 - 10.1186/s13550-015-0083-5

DO - 10.1186/s13550-015-0083-5

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JO - EJNMMI research

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IS - 1

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ER -

The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

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