The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

A. de Ronde; C. J. A. Sol; A. van Strien; J. ter Schegget; J. van der Noordaa

doi:10.1016/0042-6822(89)90534-5

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

A. de Ronde
, C. J. A. Sol
, A. van Strien
, J. ter Schegget
, J. van der Noordaa^*

^*Corresponding author for this work

Amsterdam UMC - University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts. © 1989.

Original language	English
Pages (from-to)	260-263
Journal	Virology
Volume	171
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(89)90534-5
Publication status	Published - 1989
Externally published	Yes

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10.1016/0042-6822(89)90534-5

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title = "The SV40 small t antigen is essential for the morphological transformation of human fibroblasts",

abstract = "The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts. {\textcopyright} 1989.",

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doi = "10.1016/0042-6822(89)90534-5",

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T1 - The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

AU - de Ronde, A.

AU - Sol, C. J. A.

AU - van Strien, A.

AU - ter Schegget, J.

AU - van der Noordaa, J.

PY - 1989

Y1 - 1989

N2 - The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts. © 1989.

AB - The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts. © 1989.

UR - https://www.scopus.com/pages/publications/0024328481

UR - https://www.ncbi.nlm.nih.gov/pubmed/2662578

U2 - 10.1016/0042-6822(89)90534-5

DO - 10.1016/0042-6822(89)90534-5

M3 - Article

C2 - 2662578

SN - 0042-6822

VL - 171

SP - 260

EP - 263

JO - Virology

JF - Virology

IS - 1

ER -

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

Abstract

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