The struggle to detect circulating DNA

Sacha Zeerleder

doi:10.1186/cc4932

The struggle to detect circulating DNA

Sacha Zeerleder

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performed by real-time quantitative PCR or immunological methods such as ELISA. The diagnostic value of both methods can be impaired by inappropriate handling of the samples. Assessment of circulating DNA in patients admitted to the intensive care unit offers a tool for predicting morbidity and mortality

Original language	English
Pages (from-to)	142
Journal	Critical care (London, England)
Volume	10
Issue number	3
DOIs	https://doi.org/10.1186/cc4932
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1186/cc4932

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title = "The struggle to detect circulating DNA",

abstract = "In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performed by real-time quantitative PCR or immunological methods such as ELISA. The diagnostic value of both methods can be impaired by inappropriate handling of the samples. Assessment of circulating DNA in patients admitted to the intensive care unit offers a tool for predicting morbidity and mortality",

author = "Sacha Zeerleder",

year = "2006",

doi = "10.1186/cc4932",

language = "English",

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journal = "Critical care (London, England)",

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T1 - The struggle to detect circulating DNA

AU - Zeerleder, Sacha

PY - 2006

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AB - In various diseases, such as cancer, autoimmune disease, sepsis or myocardial infarction, elevated levels of circulating DNA can be measured. However, its predictive value is under debate. Circulating DNA in plasma is protein-bound (nucleosomal) DNA. Quantification of circulating DNA can be performed by real-time quantitative PCR or immunological methods such as ELISA. The diagnostic value of both methods can be impaired by inappropriate handling of the samples. Assessment of circulating DNA in patients admitted to the intensive care unit offers a tool for predicting morbidity and mortality

U2 - 10.1186/cc4932

DO - 10.1186/cc4932

M3 - Editorial

C2 - 16719935

SN - 1364-8535

VL - 10

SP - 142

JO - Critical care (London, England)

JF - Critical care (London, England)

IS - 3

ER -

The struggle to detect circulating DNA

Abstract

UN SDGs

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