The role of the cerebellum in multiple sclerosis—150 years after Charcot

MAGNIMS Study Group

doi:10.1016/j.neubiorev.2018.02.012

The role of the cerebellum in multiple sclerosis—150 years after Charcot

MAGNIMS Study Group

University Hospital Basel
Georg-August-University Göttingen
Vita-Salute San Raffaele University
Royal Holloway University of London
University of Pavia
Autonomous University of Barcelona
Novartis
Medical Imaging Analysis Center (MIAC) AG, CH- 4056 Basel, Switzerland
University Hospital and University of Basel
Medical University of Graz

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

Original language	English
Pages (from-to)	85-98
Journal	Neuroscience and biobehavioral reviews
Volume	89
DOIs	https://doi.org/10.1016/j.neubiorev.2018.02.012
Publication status	Published - 2018

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10.1016/j.neubiorev.2018.02.012

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@article{188090d030f940ed98128017c31f4ba6,

title = "The role of the cerebellum in multiple sclerosis—150 years after Charcot",

abstract = "Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.",

author = "\{MAGNIMS Study Group\} and Katrin Parmar and Christine Stadelmann and Rocca, \{Maria A.\} and Dawn Langdon and Egidio D'Angelo and Marcus D'Souza and Jessica Burggraaff and Christiane Wegner and Jaume Sastre-Garriga and Alonso Barrantes-Freer and Jonas Dorn and Uitdehaag, \{Bernard M. J.\} and Xavier Montalban and Jens Wuerfel and Christian Enzinger and Alex Rovira and Mar Tintore and Massimo Filippi and Ludwig Kappos and Till Sprenger",

year = "2018",

doi = "10.1016/j.neubiorev.2018.02.012",

language = "English",

volume = "89",

pages = "85--98",

journal = "Neuroscience and biobehavioral reviews",

issn = "0149-7634",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - The role of the cerebellum in multiple sclerosis—150 years after Charcot

AU - MAGNIMS Study Group

AU - Parmar, Katrin

AU - Stadelmann, Christine

AU - Rocca, Maria A.

AU - Langdon, Dawn

AU - D'Angelo, Egidio

AU - D'Souza, Marcus

AU - Burggraaff, Jessica

AU - Wegner, Christiane

AU - Sastre-Garriga, Jaume

AU - Barrantes-Freer, Alonso

AU - Dorn, Jonas

AU - Uitdehaag, Bernard M. J.

AU - Montalban, Xavier

AU - Wuerfel, Jens

AU - Enzinger, Christian

AU - Rovira, Alex

AU - Tintore, Mar

AU - Filippi, Massimo

AU - Kappos, Ludwig

AU - Sprenger, Till

PY - 2018

Y1 - 2018

N2 - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

AB - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

UR - https://www.scopus.com/pages/publications/85042865988

UR - https://www.ncbi.nlm.nih.gov/pubmed/29477616

U2 - 10.1016/j.neubiorev.2018.02.012

DO - 10.1016/j.neubiorev.2018.02.012

M3 - Review article

C2 - 29477616

SN - 0149-7634

VL - 89

SP - 85

EP - 98

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

ER -

The role of the cerebellum in multiple sclerosis—150 years after Charcot

Abstract

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