The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Wen Tian; Shirley Y. Jiang; Xinguo Jiang; Rasa Tamosiuniene; Dongeon Kim; Torrey Guan; Siham Arsalane; Shravani Pasupneti; Norbert F. Voelkel; Qizhi Tang; Mark R. Nicolls

doi:10.3389/fimmu.2021.684657

The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Wen Tian
, Shirley Y. Jiang
, Xinguo Jiang
, Rasa Tamosiuniene
, Dongeon Kim
, Torrey Guan
, Siham Arsalane
, Shravani Pasupneti
, Norbert F. Voelkel
, Qizhi Tang
, Mark R. Nicolls^*

^*Corresponding author for this work

Department of Veterans Affairs
Stanford University
Amsterdam UMC - University of Amsterdam
University of California at San Francisco

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

Original language	English
Article number	684657
Journal	Frontiers in immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.684657
Publication status	Published - 19 Aug 2021
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@article{abd333cef1f543f386d26a97dfa695aa,

title = "The Role of Regulatory T Cells in Pulmonary Arterial Hypertension",

abstract = "Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.",

author = "Wen Tian and Jiang, \{Shirley Y.\} and Xinguo Jiang and Rasa Tamosiuniene and Dongeon Kim and Torrey Guan and Siham Arsalane and Shravani Pasupneti and Voelkel, \{Norbert F.\} and Qizhi Tang and Nicolls, \{Mark R.\}",

year = "2021",

month = aug,

day = "19",

doi = "10.3389/fimmu.2021.684657",

language = "English",

volume = "12",

journal = "Frontiers in immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

AU - Tian, Wen

AU - Jiang, Shirley Y.

AU - Jiang, Xinguo

AU - Tamosiuniene, Rasa

AU - Kim, Dongeon

AU - Guan, Torrey

AU - Arsalane, Siham

AU - Pasupneti, Shravani

AU - Voelkel, Norbert F.

AU - Tang, Qizhi

AU - Nicolls, Mark R.

PY - 2021/8/19

Y1 - 2021/8/19

N2 - Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

AB - Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

UR - https://www.scopus.com/pages/publications/85114354598

UR - https://www.ncbi.nlm.nih.gov/pubmed/34489935

U2 - 10.3389/fimmu.2021.684657

DO - 10.3389/fimmu.2021.684657

M3 - Review article

C2 - 34489935

SN - 1664-3224

VL - 12

JO - Frontiers in immunology

JF - Frontiers in immunology

M1 - 684657

ER -

The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

Abstract

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