The researcher's guide to selecting biomarkers in mental health studies

Josine E. Verhoeven; Owen M. Wolkowitz; Isaac Barr Satz; Quinn Conklin; Femke Lamers; Catharina Lavebratt; Jue Lin; Daniel Lindqvist; Stefanie E. Mayer; Philippe A. Melas; Yuri Milaneschi; Martin Picard; Ryan Rampersaud; Natalie Rasgon; Kathryn Ridout; Gustav Söderberg Veibäck; Caroline Trumpff; Audrey R. Tyrka; Kathleen Watson; Gwyneth Winnie Y. Wu; Ruoting Yang; Anthony S. Zannas; Laura K. M. Han; Kristoffer N. T. Månsson

doi:10.1002/bies.202300246

The researcher's guide to selecting biomarkers in mental health studies

Josine E. Verhoeven^*
, Owen M. Wolkowitz
, Isaac Barr Satz
, Quinn Conklin
, Femke Lamers
, Catharina Lavebratt
, Jue Lin
, Daniel Lindqvist
, Stefanie E. Mayer
, Philippe A. Melas
, Yuri Milaneschi
, Martin Picard
, Ryan Rampersaud
, Natalie Rasgon
, Kathryn Ridout
, Gustav Söderberg Veibäck
, Caroline Trumpff
, Audrey R. Tyrka
, Kathleen Watson
, Gwyneth Winnie Y. Wu

Ruoting Yang, Anthony S. Zannas, Laura K. M. Han, Kristoffer N. T. Månsson

^*Corresponding author for this work

Vrije Universiteit Amsterdam
Amsterdam UMC
University of California at San Francisco
Stanford University
University of California at Davis
Karolinska Institutet
Lund University
Scania Regional Council
Columbia University
Kaiser Permanente
Brown University
Walter Reed Army Institute of Research
University of North Carolina at Chapel Hill
University of Melbourne
ORYGEN Youth Health
Babes-Bolyai University

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.

Original language	English
Article number	2300246
Journal	BioEssays
Volume	46
Issue number	10
DOIs	https://doi.org/10.1002/bies.202300246
Publication status	Published - 1 Oct 2024

Keywords

biomarker
guideline
mental health
peripheral
psychiatric disorders

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Verhoeven, J. E., Wolkowitz, O. M., Barr Satz, I., Conklin, Q., Lamers, F., Lavebratt, C., Lin, J., Lindqvist, D., Mayer, S. E., Melas, P. A., Milaneschi, Y., Picard, M., Rampersaud, R., Rasgon, N., Ridout, K., Söderberg Veibäck, G., Trumpff, C., Tyrka, A. R., Watson, K., ... Månsson, K. N. T. (2024). The researcher's guide to selecting biomarkers in mental health studies. BioEssays, 46(10), Article 2300246. https://doi.org/10.1002/bies.202300246

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title = "The researcher's guide to selecting biomarkers in mental health studies",

abstract = "Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.",

keywords = "biomarker, guideline, mental health, peripheral, psychiatric disorders",

author = "Verhoeven, \{Josine E.\} and Wolkowitz, \{Owen M.\} and \{Barr Satz\}, Isaac and Quinn Conklin and Femke Lamers and Catharina Lavebratt and Jue Lin and Daniel Lindqvist and Mayer, \{Stefanie E.\} and Melas, \{Philippe A.\} and Yuri Milaneschi and Martin Picard and Ryan Rampersaud and Natalie Rasgon and Kathryn Ridout and \{S{\"o}derberg Veib{\"a}ck\}, Gustav and Caroline Trumpff and Tyrka, \{Audrey R.\} and Kathleen Watson and Wu, \{Gwyneth Winnie Y.\} and Ruoting Yang and Zannas, \{Anthony S.\} and Han, \{Laura K. M.\} and M{\aa}nsson, \{Kristoffer N. T.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. BioEssays published by Wiley Periodicals LLC.",

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Verhoeven, JE, Wolkowitz, OM, Barr Satz, I, Conklin, Q, Lamers, F, Lavebratt, C, Lin, J, Lindqvist, D, Mayer, SE, Melas, PA, Milaneschi, Y, Picard, M, Rampersaud, R, Rasgon, N, Ridout, K, Söderberg Veibäck, G, Trumpff, C, Tyrka, AR, Watson, K, Wu, GWY, Yang, R, Zannas, AS, Han, LKM & Månsson, KNT 2024, 'The researcher's guide to selecting biomarkers in mental health studies', BioEssays, vol. 46, no. 10, 2300246. https://doi.org/10.1002/bies.202300246

TY - JOUR

T1 - The researcher's guide to selecting biomarkers in mental health studies

AU - Verhoeven, Josine E.

AU - Wolkowitz, Owen M.

AU - Barr Satz, Isaac

AU - Conklin, Quinn

AU - Lamers, Femke

AU - Lavebratt, Catharina

AU - Lin, Jue

AU - Lindqvist, Daniel

AU - Mayer, Stefanie E.

AU - Melas, Philippe A.

AU - Milaneschi, Yuri

AU - Picard, Martin

AU - Rampersaud, Ryan

AU - Rasgon, Natalie

AU - Ridout, Kathryn

AU - Söderberg Veibäck, Gustav

AU - Trumpff, Caroline

AU - Tyrka, Audrey R.

AU - Watson, Kathleen

AU - Wu, Gwyneth Winnie Y.

AU - Yang, Ruoting

AU - Zannas, Anthony S.

AU - Han, Laura K. M.

AU - Månsson, Kristoffer N. T.

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.

AB - Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.

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KW - guideline

KW - mental health

KW - peripheral

KW - psychiatric disorders

UR - https://www.scopus.com/pages/publications/85203498973

U2 - 10.1002/bies.202300246

DO - 10.1002/bies.202300246

M3 - Review article

C2 - 39258367

SN - 0265-9247

VL - 46

JO - BioEssays

JF - BioEssays

IS - 10

M1 - 2300246

ER -

The researcher's guide to selecting biomarkers in mental health studies

Abstract

Keywords

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