The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

Claudia M. Persoon; Rein I. Hoogstraaten; Joris P. Nassal; Jan R.T. van Weering; Pascal S. Kaeser; Ruud F. Toonen; Matthijs Verhage

doi:10.1016/j.neuron.2019.09.015

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

Claudia M. Persoon
, Rein I. Hoogstraaten
, Joris P. Nassal
, Jan R.T. van Weering
, Pascal S. Kaeser
, Ruud F. Toonen^*
, Matthijs Verhage

^*Corresponding author for this work

Vrije Universiteit Amsterdam
Harvard University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.

Original language	English
Pages (from-to)	1065-1080.e12
Journal	Neuron
Volume	104
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2019.09.015
Publication status	Published - 18 Dec 2019

Keywords

BDNF
dense-core vesicles
MUNC13
neuromodulators
neuropeptide
NPY
RAB3
RIM1/2
SEC4
secretion

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10.1016/j.neuron.2019.09.015

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title = "The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators",

abstract = "Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3{\textquoteright}s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.",

keywords = "BDNF, dense-core vesicles, MUNC13, neuromodulators, neuropeptide, NPY, RAB3, RIM1/2, SEC4, secretion",

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AU - Persoon, Claudia M.

AU - Hoogstraaten, Rein I.

AU - Nassal, Joris P.

AU - van Weering, Jan R.T.

AU - Kaeser, Pascal S.

AU - Toonen, Ruud F.

AU - Verhage, Matthijs

PY - 2019/12/18

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AB - Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.

KW - BDNF

KW - dense-core vesicles

KW - MUNC13

KW - neuromodulators

KW - neuropeptide

KW - NPY

KW - RAB3

KW - RIM1/2

KW - SEC4

KW - secretion

UR - https://www.scopus.com/pages/publications/85076236214

U2 - 10.1016/j.neuron.2019.09.015

DO - 10.1016/j.neuron.2019.09.015

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SP - 1065-1080.e12

JO - Neuron

JF - Neuron

IS - 6

ER -

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

Abstract

Keywords

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