The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications

PROVIDI Study Group

doi:10.1097/RCT.0b013e318231824a

The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications

PROVIDI Study Group

Radiology and Nuclear Medicine

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [email protected]

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.

METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.

RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.

CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.

Original language	English
Pages (from-to)	734-41
Number of pages	8
Journal	Journal of computer assisted tomography
Volume	35
Issue number	6
DOIs	https://doi.org/10.1097/RCT.0b013e318231824a
Publication status	Published - 16 Nov 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Aorta, Thoracic
Cardiovascular Diseases
Case-Control Studies
Chi-Square Distribution
Female
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Radiography, Thoracic
Regression Analysis
Tomography, X-Ray Computed
Journal Article
Research Support, Non-U.S. Gov't

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10.1097/RCT.0b013e318231824a

Cite this

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title = "The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications",

abstract = "OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95\% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95\% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95\% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95\% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.",

keywords = "Adult, Aged, Aorta, Thoracic, Cardiovascular Diseases, Case-Control Studies, Chi-Square Distribution, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Radiography, Thoracic, Regression Analysis, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't",

author = "\{PROVIDI Study Group\} and Gondrie, \{Martijn J A\} and \{van der Graaf\}, Yolanda and Jacobs, \{Peter C\} and Buckens, \{Stan C F M\} and Mali, \{Willem P. Th. M.\}",

year = "2011",

month = nov,

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doi = "10.1097/RCT.0b013e318231824a",

language = "English",

volume = "35",

pages = "734--41",

journal = "Journal of computer assisted tomography",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications

AU - PROVIDI Study Group

AU - Gondrie, Martijn J A

AU - van der Graaf, Yolanda

AU - Jacobs, Peter C

AU - Buckens, Stan C F M

AU - Mali, Willem P. Th. M.

PY - 2011/11/16

Y1 - 2011/11/16

N2 - OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.

AB - OBJECTIVES: The aim of the study was to investigate whether diameter measurements of the thoracic aorta and the heart can be used as prognostic markers for future cardiovascular disease.METHODS: Following a case-cohort design, a total of 10,410 patients undergoing chest computed tomography were followed up for a mean period of 17 months. The ones with a cardiovascular indication were excluded. Diameter measurements were evaluated with Cox proportional hazard analysis.RESULTS: Five hundred fifteen incident cardiovascular events occurred during follow-up. The heart (hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.03-1.06) and ascending thoracic (HR, 1.002; 95% CI, 1.001-1.004) diameter showed an exponential prognostic effect beyond a threshold diameter of, respectively, 11 and 30 mm; the descending aortic diameter (HR, 1.04; 95% CI, 1.01-1.13) and cardiothoracic ratio (HR, 1.06; 95% CI, 1.04-1.08) showed linear prognostic effects beyond, respectively, 25 and 0.45 mm.CONCLUSION: Intrathoracic diameter measurements can be used as markers to predict cardiovascular events in patients not referred for that disease outcome.

KW - Adult

KW - Aged

KW - Aorta, Thoracic

KW - Cardiovascular Diseases

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prognosis

KW - Proportional Hazards Models

KW - Radiography, Thoracic

KW - Regression Analysis

KW - Tomography, X-Ray Computed

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1097/RCT.0b013e318231824a

M3 - Article

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SP - 734

EP - 741

JO - Journal of computer assisted tomography

JF - Journal of computer assisted tomography

IS - 6

ER -

The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications

Abstract

UN SDGs

Keywords

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