TY - JOUR
T1 - The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior
AU - Dolleman-van der Weel, Margriet J.
AU - Griffin, Amy L.
AU - Ito, Hiroshi T.
AU - Shapiro, Matthew L.
AU - Witter, Menno P.
AU - Vertes, Robert P.
AU - Allen, Timothy A.
N1 - Funding Information:
1Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam NL-1007MB, The Netherlands; 2Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam NL-1098XH, The Netherlands; 3Department of Psychological and Brain Sciences, University of Delaware, Newark, Delaware 19716, USA; 4Max Planck Institute for Brain Research, 60438, Frankfurt am Main, Germany; 5Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York 12208, USA; 6Kavli Institute for Systems Neuroscience and Centre for Neural Computation, NTNU Norwegian University of Science and Technology, Trondheim NO-7491, Norway; 7Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA; 8Cognitive Neuroscience Program, Department of Psychology, Florida International University, Miami, Florida 33199, USA; 9Department of Environmental Health Sciences, Florida International University, Miami, Florida 33199, USA
Funding Information:
We thank Dr. Tatiana Viena for helpful feedback on the manuscript. This work was supported, in part, by NIH grant R01 MH113626 to T.A.A., NIH grant R01 MH102394 to A.L.G., and NIH grant R15 NS108259 to R.P.V. H.T.I. is funded by the Max Planck Society, the Behrens-Weise Foundation, a Starting Grant from the European Research Council (“NavigationCircuits” Grant Agreement no. 714642), and a PRESTO grant from the Japan Science and Technology Agency (JPMJPR1682).
Publisher Copyright:
© 2019 Cold Spring Harbor Laboratory Press. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
AB - The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
UR - https://www.scopus.com/pages/publications/85068386366
U2 - 10.1101/lm.048389.118
DO - 10.1101/lm.048389.118
M3 - Review article
C2 - 31209114
SN - 1072-0502
VL - 26
SP - 191
EP - 205
JO - Learning & memory (Cold Spring Harbor, N.Y.)
JF - Learning & memory (Cold Spring Harbor, N.Y.)
IS - 7
ER -