The nature and identification of quantitative trait loci: A community's view

Oduola Abiola; Joe M. Angel; Philip Avner; Alexander A. Bachmanov; John K. Belknap; Beth Bennett; Elizabeth P. Blankenhorn; David A. Blizard; Valerie Bolivar; Gudrun A. Brockmann; Kari J. Buck; Jean-Francois Bureau; William L. Casley; Elissa J. Chesler; James M. Cheverud; Gary A. Churchill; Melloni Cook; John C. Crabbe; Wim E. Crusio; Ariel Darvasi; Gerald de Haan; Peter Demant; R. W. Doerge; Rosemary W. Elliott; Charles R. Farber; Lorraine Flaherty; Jonathan Flint; Howard Gershenfeld; John P. Gibson; Jing Gu; Weikuan Gu; Heinz Himmelbauer; Robert Hitzemann; Hui-Chen Hsu; Kent Hunter; Fuad A. Iraqi; Ritsert C. Jansen; Thomas E. Johnson; Byron C. Jones; Gerd Kempermann; Frank Lammert; Lu Lu; Kenneth F. Manly; Douglas B. Matthews; Juan F. Medrano; Margarete Mehrabian; Guy Mittleman; Beverly A. Mock; Jeffrey S. Mogil; Xavier Montagutelli; Grant Morahan; John D. Mountz; Hiroki Nagase; Richard S. Nowakowski; Bruce F. O'Hara; Alexander V. Osadchuk; Beverly Paigen; Abraham A. Palmer; Jeremy L. Peirce; Daniel Pomp; Michael Rosemann; Glenn D. Rosen; Leonard C. Schalkwyk; Ze'ev Seltzer; Stephen Settle; Kazuhiro Shimomura; Siming Shou; James M. Sikela; Linda D. Siracusa; Jimmy L. Spearow; Cory Teuscher; David W. Threadgill; Linda A. Toth; Ayo A. Toye; Csaba Vadasz; Gary van Zant; Edward Wakeland; Robert W. Williams; Huang-Ge Zhang; Fei Zou

doi:10.1038/nrg1206

The nature and identification of quantitative trait loci: A community's view

Oduola Abiola
, Joe M. Angel
, Philip Avner
, Alexander A. Bachmanov
, John K. Belknap
, Beth Bennett
, Elizabeth P. Blankenhorn
, David A. Blizard
, Valerie Bolivar
, Gudrun A. Brockmann
, Kari J. Buck
, Jean-Francois Bureau
, William L. Casley
, Elissa J. Chesler
, James M. Cheverud
, Gary A. Churchill
, Melloni Cook
, John C. Crabbe
, Wim E. Crusio
, Ariel Darvasi

Gerald de Haan, Peter Demant, R. W. Doerge, Rosemary W. Elliott, Charles R. Farber, Lorraine Flaherty, Jonathan Flint, Howard Gershenfeld, John P. Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui-Chen Hsu, Kent Hunter, Fuad A. Iraqi, Ritsert C. Jansen, Thomas E. Johnson, Byron C. Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F. Manly, Douglas B. Matthews, Juan F. Medrano, Margarete Mehrabian, Guy Mittleman, Beverly A. Mock, Jeffrey S. Mogil, Xavier Montagutelli, Grant Morahan, John D. Mountz, Hiroki Nagase, Richard S. Nowakowski, Bruce F. O'Hara, Alexander V. Osadchuk, Beverly Paigen, Abraham A. Palmer, Jeremy L. Peirce, Daniel Pomp, Michael Rosemann, Glenn D. Rosen, Leonard C. Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M. Sikela, Linda D. Siracusa, Jimmy L. Spearow, Cory Teuscher, David W. Threadgill, Linda A. Toth, Ayo A. Toye, Csaba Vadasz, Gary van Zant, Edward Wakeland, Robert W. Williams, Huang-Ge Zhang, Fei Zou

King's College London
University of Texas MD Anderson Cancer Center
Institut Pasteur Paris
Monell Chemical Senses Center
Oregon Health and Science University
University of Colorado Boulder
Drexel University
Pennsylvania State University
Wadsworth Center for Laboratories and Research
Leibniz Institute for Farm Animal Biology
Health Canada
University of Tennessee Health Science Center
Washington University St. Louis
Jackson Laboratory
University of Memphis
University of Massachusetts Medical School
Hebrew University of Jerusalem
University of Groningen
Roswell Park Cancer Institute
Purdue University
University of California at Davis
University of Oxford
University of Texas Southwestern Medical Center
International Livestock Research Institute
Max Planck Institute for Molecular Genetics
University of Alabama at Birmingham
National Institutes of Health
Charité – Universitätsmedizin Berlin
RWTH Aachen University
University of California at Los Angeles
McGill University
Royal Melbourne Hospital
Rutgers - The State University of New Jersey, New Brunswick
Stanford University
RAS - Institute of Cytology and Genetics, Siberian Branch
Columbia University
Princeton University
University of Nebraska-Lincoln
Helmholtz Zentrum München - German Research Center for Environmental Health
Harvard University
Centre for the Study of Pain and Faculty of Dentistry, Canada
Vanderbilt University
Northwestern University
Shriners Hospital, United States
University of Colorado Anschutz Medical Campus
Thomas Jefferson University
University of Vermont
University of North Carolina at Chapel Hill
Southern Illinois University
Medical Research Council
New York University
University of Kentucky

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Original language	English
Pages (from-to)	911-916
Journal	Nature reviews. Genetics
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nrg1206
Publication status	Published - Nov 2003
Externally published	Yes

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10.1038/nrg1206

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Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J.-F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., Crusio, W. E., ... Zou, F. (2003). The nature and identification of quantitative trait loci: A community's view. Nature reviews. Genetics, 4(11), 911-916. https://doi.org/10.1038/nrg1206

@article{f99c497d4c21413bbba5141c4d41cf5f,

title = "The nature and identification of quantitative trait loci: A community's view",

abstract = "This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?",

author = "Oduola Abiola and Angel, \{Joe M.\} and Philip Avner and Bachmanov, \{Alexander A.\} and Belknap, \{John K.\} and Beth Bennett and Blankenhorn, \{Elizabeth P.\} and Blizard, \{David A.\} and Valerie Bolivar and Brockmann, \{Gudrun A.\} and Buck, \{Kari J.\} and Jean-Francois Bureau and Casley, \{William L.\} and Chesler, \{Elissa J.\} and Cheverud, \{James M.\} and Churchill, \{Gary A.\} and Melloni Cook and Crabbe, \{John C.\} and Crusio, \{Wim E.\} and Ariel Darvasi and \{de Haan\}, Gerald and Peter Demant and Doerge, \{R. W.\} and Elliott, \{Rosemary W.\} and Farber, \{Charles R.\} and Lorraine Flaherty and Jonathan Flint and Howard Gershenfeld and Gibson, \{John P.\} and Jing Gu and Weikuan Gu and Heinz Himmelbauer and Robert Hitzemann and Hui-Chen Hsu and Kent Hunter and Iraqi, \{Fuad A.\} and Jansen, \{Ritsert C.\} and Johnson, \{Thomas E.\} and Jones, \{Byron C.\} and Gerd Kempermann and Frank Lammert and Lu Lu and Manly, \{Kenneth F.\} and Matthews, \{Douglas B.\} and Medrano, \{Juan F.\} and Margarete Mehrabian and Guy Mittleman and Mock, \{Beverly A.\} and Mogil, \{Jeffrey S.\} and Xavier Montagutelli and Grant Morahan and Mountz, \{John D.\} and Hiroki Nagase and Nowakowski, \{Richard S.\} and O'Hara, \{Bruce F.\} and Osadchuk, \{Alexander V.\} and Beverly Paigen and Palmer, \{Abraham A.\} and Peirce, \{Jeremy L.\} and Daniel Pomp and Michael Rosemann and Rosen, \{Glenn D.\} and Schalkwyk, \{Leonard C.\} and Ze'ev Seltzer and Stephen Settle and Kazuhiro Shimomura and Siming Shou and Sikela, \{James M.\} and Siracusa, \{Linda D.\} and Spearow, \{Jimmy L.\} and Cory Teuscher and Threadgill, \{David W.\} and Toth, \{Linda A.\} and Toye, \{Ayo A.\} and Csaba Vadasz and \{van Zant\}, Gary and Edward Wakeland and Williams, \{Robert W.\} and Huang-Ge Zhang and Fei Zou",

year = "2003",

month = nov,

doi = "10.1038/nrg1206",

language = "English",

volume = "4",

pages = "911--916",

journal = "Nature reviews. Genetics",

issn = "1471-0056",

publisher = "Nature Publishing Group",

number = "11",

}

Abiola, O, Angel, JM, Avner, P, Bachmanov, AA, Belknap, JK, Bennett, B, Blankenhorn, EP, Blizard, DA, Bolivar, V, Brockmann, GA, Buck, KJ, Bureau, J-F, Casley, WL, Chesler, EJ, Cheverud, JM, Churchill, GA, Cook, M, Crabbe, JC, Crusio, WE, Darvasi, A, de Haan, G, Demant, P, Doerge, RW, Elliott, RW, Farber, CR, Flaherty, L, Flint, J, Gershenfeld, H, Gibson, JP, Gu, J, Gu, W, Himmelbauer, H, Hitzemann, R, Hsu, H-C, Hunter, K, Iraqi, FA, Jansen, RC, Johnson, TE, Jones, BC, Kempermann, G, Lammert, F, Lu, L, Manly, KF, Matthews, DB, Medrano, JF, Mehrabian, M, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, X, Morahan, G, Mountz, JD, Nagase, H, Nowakowski, RS, O'Hara, BF, Osadchuk, AV, Paigen, B, Palmer, AA, Peirce, JL, Pomp, D, Rosemann, M, Rosen, GD, Schalkwyk, LC, Seltzer, Z, Settle, S, Shimomura, K, Shou, S, Sikela, JM, Siracusa, LD, Spearow, JL, Teuscher, C, Threadgill, DW, Toth, LA, Toye, AA, Vadasz, C, van Zant, G, Wakeland, E, Williams, RW, Zhang, H-G & Zou, F 2003, 'The nature and identification of quantitative trait loci: A community's view', Nature reviews. Genetics, vol. 4, no. 11, pp. 911-916. https://doi.org/10.1038/nrg1206

TY - JOUR

T1 - The nature and identification of quantitative trait loci: A community's view

AU - Abiola, Oduola

AU - Angel, Joe M.

AU - Avner, Philip

AU - Bachmanov, Alexander A.

AU - Belknap, John K.

AU - Bennett, Beth

AU - Blankenhorn, Elizabeth P.

AU - Blizard, David A.

AU - Bolivar, Valerie

AU - Brockmann, Gudrun A.

AU - Buck, Kari J.

AU - Bureau, Jean-Francois

AU - Casley, William L.

AU - Chesler, Elissa J.

AU - Cheverud, James M.

AU - Churchill, Gary A.

AU - Cook, Melloni

AU - Crabbe, John C.

AU - Crusio, Wim E.

AU - Darvasi, Ariel

AU - de Haan, Gerald

AU - Demant, Peter

AU - Doerge, R. W.

AU - Elliott, Rosemary W.

AU - Farber, Charles R.

AU - Flaherty, Lorraine

AU - Flint, Jonathan

AU - Gershenfeld, Howard

AU - Gibson, John P.

AU - Gu, Jing

AU - Gu, Weikuan

AU - Himmelbauer, Heinz

AU - Hitzemann, Robert

AU - Hsu, Hui-Chen

AU - Hunter, Kent

AU - Iraqi, Fuad A.

AU - Jansen, Ritsert C.

AU - Johnson, Thomas E.

AU - Jones, Byron C.

AU - Kempermann, Gerd

AU - Lammert, Frank

AU - Lu, Lu

AU - Manly, Kenneth F.

AU - Matthews, Douglas B.

AU - Medrano, Juan F.

AU - Mehrabian, Margarete

AU - Mittleman, Guy

AU - Mock, Beverly A.

AU - Mogil, Jeffrey S.

AU - Montagutelli, Xavier

AU - Morahan, Grant

AU - Mountz, John D.

AU - Nagase, Hiroki

AU - Nowakowski, Richard S.

AU - O'Hara, Bruce F.

AU - Osadchuk, Alexander V.

AU - Paigen, Beverly

AU - Palmer, Abraham A.

AU - Peirce, Jeremy L.

AU - Pomp, Daniel

AU - Rosemann, Michael

AU - Rosen, Glenn D.

AU - Schalkwyk, Leonard C.

AU - Seltzer, Ze'ev

AU - Settle, Stephen

AU - Shimomura, Kazuhiro

AU - Shou, Siming

AU - Sikela, James M.

AU - Siracusa, Linda D.

AU - Spearow, Jimmy L.

AU - Teuscher, Cory

AU - Threadgill, David W.

AU - Toth, Linda A.

AU - Toye, Ayo A.

AU - Vadasz, Csaba

AU - van Zant, Gary

AU - Wakeland, Edward

AU - Williams, Robert W.

AU - Zhang, Huang-Ge

AU - Zou, Fei

PY - 2003/11

Y1 - 2003/11

N2 - This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

AB - This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

UR - https://www.scopus.com/pages/publications/0242291131

UR - https://www.ncbi.nlm.nih.gov/pubmed/14634638

U2 - 10.1038/nrg1206

DO - 10.1038/nrg1206

M3 - Review article

C2 - 14634638

SN - 1471-0056

VL - 4

SP - 911

EP - 916

JO - Nature reviews. Genetics

JF - Nature reviews. Genetics

IS - 11

ER -

The nature and identification of quantitative trait loci: A community's view

Abstract

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