The multifaceted role of serotonin in intestinal homeostasis

Nienke Koopman; Drosos Katsavelis; Anne S. ten Hove; Stanley Brul; Wouter J. de Jonge; Jurgen Seppen

doi:10.3390/ijms22179487

The multifaceted role of serotonin in intestinal homeostasis

Nienke Koopman
, Drosos Katsavelis
, Anne S. ten Hove
, Stanley Brul
, Wouter J. de Jonge
, Jurgen Seppen^*

^*Corresponding author for this work

University of Amsterdam
Amsterdam UMC - University of Amsterdam

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.

Original language	English
Article number	9487
Journal	International journal of molecular sciences
Volume	22
Issue number	17
DOIs	https://doi.org/10.3390/ijms22179487
Publication status	Published - 1 Sept 2021

Keywords

Inflammatory bowel disease
Intestine
Microbiome
Tryptophan

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title = "The multifaceted role of serotonin in intestinal homeostasis",

abstract = "The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.",

keywords = "Inflammatory bowel disease, Intestine, Microbiome, Tryptophan",

author = "Nienke Koopman and Drosos Katsavelis and \{ten Hove\}, \{Anne S.\} and Stanley Brul and \{de Jonge\}, \{Wouter J.\} and Jurgen Seppen",

note = "Funding Information: The authors declare this work was not performed using specific funding; it was generated as part of routine work for the University of Amsterdam and Amsterdam, UMC. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

day = "1",

doi = "10.3390/ijms22179487",

language = "English",

volume = "22",

journal = "International journal of molecular sciences",

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T1 - The multifaceted role of serotonin in intestinal homeostasis

AU - Koopman, Nienke

AU - Katsavelis, Drosos

AU - ten Hove, Anne S.

AU - Brul, Stanley

AU - de Jonge, Wouter J.

AU - Seppen, Jurgen

N1 - Funding Information: The authors declare this work was not performed using specific funding; it was generated as part of routine work for the University of Amsterdam and Amsterdam, UMC. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.

AB - The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.

KW - Inflammatory bowel disease

KW - Intestine

KW - Microbiome

KW - Tryptophan

UR - https://www.scopus.com/pages/publications/85114034535

U2 - 10.3390/ijms22179487

DO - 10.3390/ijms22179487

M3 - Review article

C2 - 34502396

SN - 1661-6596

VL - 22

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 17

M1 - 9487

ER -

The multifaceted role of serotonin in intestinal homeostasis

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Keywords

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