The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V

Ellen W. Easton; Irene Blokland; Albert A. Geldof; B. Ramanath Rao; Dirk H. van den Eijnden

doi:10.1016/0014-5793(92)81047-P

The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V

Ellen W. Easton
, Irene Blokland
, Albert A. Geldof
, B. Ramanath Rao
, Dirk H. van den Eijnden^*

^*Corresponding author for this work

VU University Medical Hospital
VU Medisch Centrum

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Enzyme activities of N-acetylglucosaminyltransferase (GlcNAc-Tase) I-V involved in N-linked complex-type carbohydrate synthesis were determined in a non-metastatic hormone-dependent rat prostate tumor (R3327-H) and a related, hormone-independent variant metastasizing to lymph nodes and lungs (R3327-MatLyLu). In the metastasizing variant a significantly increased activity of both GlcNAc-Tase III and GlcNAc-Tase V was observed, whereas the activities of GlcNAc-Tase I and II were essentially unchanged. The increase in activity of GlcNAc-Tase III is particularly noteworthy since it indicates that elevated expression of this enzyme cannot be considered as an exclusive marker of hepatic malignancy.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	FEBS letters
Volume	308
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(92)81047-P
Publication status	Published - 10 Aug 1992

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Metastasis
N-Acetylglucosaminyltransferase
R3327-MatLyLu
Rat prostate tumor

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10.1016/0014-5793(92)81047-P

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title = "The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V",

abstract = "Enzyme activities of N-acetylglucosaminyltransferase (GlcNAc-Tase) I-V involved in N-linked complex-type carbohydrate synthesis were determined in a non-metastatic hormone-dependent rat prostate tumor (R3327-H) and a related, hormone-independent variant metastasizing to lymph nodes and lungs (R3327-MatLyLu). In the metastasizing variant a significantly increased activity of both GlcNAc-Tase III and GlcNAc-Tase V was observed, whereas the activities of GlcNAc-Tase I and II were essentially unchanged. The increase in activity of GlcNAc-Tase III is particularly noteworthy since it indicates that elevated expression of this enzyme cannot be considered as an exclusive marker of hepatic malignancy.",

keywords = "Metastasis, N-Acetylglucosaminyltransferase, R3327-MatLyLu, Rat prostate tumor",

author = "Easton, \{Ellen W.\} and Irene Blokland and Geldof, \{Albert A.\} and Rao, \{B. Ramanath\} and \{van den Eijnden\}, \{Dirk H.\}",

year = "1992",

month = aug,

day = "10",

doi = "10.1016/0014-5793(92)81047-P",

language = "English",

volume = "308",

pages = "46--49",

journal = "FEBS letters",

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T1 - The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V

AU - Easton, Ellen W.

AU - Blokland, Irene

AU - Geldof, Albert A.

AU - Rao, B. Ramanath

AU - van den Eijnden, Dirk H.

PY - 1992/8/10

Y1 - 1992/8/10

N2 - Enzyme activities of N-acetylglucosaminyltransferase (GlcNAc-Tase) I-V involved in N-linked complex-type carbohydrate synthesis were determined in a non-metastatic hormone-dependent rat prostate tumor (R3327-H) and a related, hormone-independent variant metastasizing to lymph nodes and lungs (R3327-MatLyLu). In the metastasizing variant a significantly increased activity of both GlcNAc-Tase III and GlcNAc-Tase V was observed, whereas the activities of GlcNAc-Tase I and II were essentially unchanged. The increase in activity of GlcNAc-Tase III is particularly noteworthy since it indicates that elevated expression of this enzyme cannot be considered as an exclusive marker of hepatic malignancy.

AB - Enzyme activities of N-acetylglucosaminyltransferase (GlcNAc-Tase) I-V involved in N-linked complex-type carbohydrate synthesis were determined in a non-metastatic hormone-dependent rat prostate tumor (R3327-H) and a related, hormone-independent variant metastasizing to lymph nodes and lungs (R3327-MatLyLu). In the metastasizing variant a significantly increased activity of both GlcNAc-Tase III and GlcNAc-Tase V was observed, whereas the activities of GlcNAc-Tase I and II were essentially unchanged. The increase in activity of GlcNAc-Tase III is particularly noteworthy since it indicates that elevated expression of this enzyme cannot be considered as an exclusive marker of hepatic malignancy.

KW - Metastasis

KW - N-Acetylglucosaminyltransferase

KW - R3327-MatLyLu

KW - Rat prostate tumor

UR - https://www.scopus.com/pages/publications/0026700850

U2 - 10.1016/0014-5793(92)81047-P

DO - 10.1016/0014-5793(92)81047-P

M3 - Article

C2 - 1386579

SN - 0014-5793

VL - 308

SP - 46

EP - 49

JO - FEBS letters

JF - FEBS letters

IS - 1

ER -

The metastatic potential of rat prostate tumor variant R3327-MatLyLu is correlated with an increased activity of N-acetylglucosaminyl transferase III and V

Abstract

UN SDGs

Keywords

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