The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

P. E. Dekkers; T. ten Hove; F. N. Lauw; H. R. Koene; P. Lumley; S. J. van Deventer; T. van der Poll

doi:10.1128/IAI.68.5.3036-3039.2000

The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

P. E. Dekkers
, T. ten Hove
, F. N. Lauw
, H. R. Koene
, P. Lumley
, S. J. van Deventer
, T. van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans

Original language	English
Pages (from-to)	3036-3039
Journal	Infection and immunity
Volume	68
Issue number	5
DOIs	https://doi.org/10.1128/IAI.68.5.3036-3039.2000
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/IAI.68.5.3036-3039.2000

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title = "The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans",

abstract = "Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans",

author = "Dekkers, \{P. E.\} and \{ten Hove\}, T. and Lauw, \{F. N.\} and Koene, \{H. R.\} and P. Lumley and \{van Deventer\}, \{S. J.\} and \{van der Poll\}, T.",

year = "2000",

doi = "10.1128/IAI.68.5.3036-3039.2000",

language = "English",

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publisher = "American Society for Microbiology",

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T1 - The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

AU - Dekkers, P. E.

AU - ten Hove, T.

AU - Lauw, F. N.

AU - Koene, H. R.

AU - Lumley, P.

AU - van Deventer, S. J.

AU - van der Poll, T.

PY - 2000

Y1 - 2000

N2 - Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans

AB - Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans

U2 - 10.1128/IAI.68.5.3036-3039.2000

DO - 10.1128/IAI.68.5.3036-3039.2000

M3 - Article

C2 - 10769011

SN - 0019-9567

VL - 68

SP - 3036

EP - 3039

JO - Infection and immunity

JF - Infection and immunity

IS - 5

ER -

The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

Abstract

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