The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study

Tom Schoenmakers; Mathie P. G. Leers; Stefan H. M. Gorissen; Inge H. M. van Loo; Frank van Rosmalen; Eda Aydeniz; Joep Schellens; Marielle Driessen; Ruben Deneer; Wilhelmine P. H. G. Verboeket-van de Venne; Petra F. G. Wolffs; Walther N. K. A. van Mook; Bas C. T. van Bussel; Stephanie Ament; M. Sesmu Arbous; Otto Bekers; Miranda van Berckel; Arjan-Kars Boer; Dirk W. van Dam; Ruben Deneer; William P. T. M. van Doorn; Tom P. Dormans; Silvia M. M. A. Evers; Tim Frenzel; Madeleen de Geus-Bosma; Judith Gillis; Iwan C. C. van der Horst; W. Nadia H. Koek; Kitty Linssen; Steven J. R. Meex; Guy J. M. Mostard; Remy L. M. Mostard; Luuk C. Otterspoor; Natal A. W. van Riel; Frans Stals; Harro van Westreenen; Albert Wolthuis; Ghislaine van Mastrigt; Andrea Peeters

doi:10.1038/s41598-024-58727-y

The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study

Tom Schoenmakers^*
, Mathie P. G. Leers
, Stefan H. M. Gorissen
, Inge H. M. van Loo
, Frank van Rosmalen
, Eda Aydeniz
, Joep Schellens
, Marielle Driessen
, Ruben Deneer
, Wilhelmine P. H. G. Verboeket-van de Venne
, Petra F. G. Wolffs
, Walther N. K. A. van Mook
, Bas C. T. van Bussel
, Stephanie Ament
, M. Sesmu Arbous
, Otto Bekers
, Miranda van Berckel
, Arjan-Kars Boer
, Dirk W. van Dam
, Ruben Deneer

William P. T. M. van Doorn, Tom P. Dormans, Silvia M. M. A. Evers, Tim Frenzel, Madeleen de Geus-Bosma, Judith Gillis, Iwan C. C. van der Horst, W. Nadia H. Koek, Kitty Linssen, Steven J. R. Meex, Guy J. M. Mostard, Remy L. M. Mostard, Luuk C. Otterspoor, Natal A. W. van Riel, Frans Stals, Harro van Westreenen, Albert Wolthuis, Ghislaine van Mastrigt, Andrea Peeters

^*Corresponding author for this work

Zuyderland
Maastricht University
Maastricht UMC+
Open Universiteit
Maastricht University Medical Center
Leiden University Medical Center
Radboud University Medical Center
Catharina Hospital
Medical Centre Leeuwarden
Eindhoven University of Technology
Certe

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.

Original language	English
Article number	8220
Journal	Scientific reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-58727-y
Publication status	Published - 1 Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
CoLab score
Linear mixed-effects models
SARS-CoV-2

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Schoenmakers, T., Leers, M. P. G., Gorissen, S. H. M., van Loo, I. H. M., van Rosmalen, F., Aydeniz, E., Schellens, J., Driessen, M., Deneer, R., de Venne, W. P. H. G. V., Wolffs, P. F. G., van Mook, W. N. K. A., van Bussel, B. C. T., Ament, S., Arbous, M. S., Bekers, O., van Berckel, M., Boer, A.-K., van Dam, D. W., ... Peeters, A. (2024). The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study. Scientific reports, 14(1), Article 8220. https://doi.org/10.1038/s41598-024-58727-y

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title = "The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study",

abstract = "The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95\% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95\% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.",

keywords = "COVID-19, CoLab score, Linear mixed-effects models, SARS-CoV-2",

author = "Tom Schoenmakers and Leers, \{Mathie P. G.\} and Gorissen, \{Stefan H. M.\} and \{van Loo\}, \{Inge H. M.\} and \{van Rosmalen\}, Frank and Eda Aydeniz and Joep Schellens and Marielle Driessen and Ruben Deneer and \{de Venne\}, \{Wilhelmine P. H. G. Verboeket-van\} and Wolffs, \{Petra F. G.\} and \{van Mook\}, \{Walther N. K. A.\} and \{van Bussel\}, \{Bas C. T.\} and Stephanie Ament and Arbous, \{M. Sesmu\} and Otto Bekers and \{van Berckel\}, Miranda and Arjan-Kars Boer and \{van Dam\}, \{Dirk W.\} and Ruben Deneer and \{van Doorn\}, \{William P. T. M.\} and Dormans, \{Tom P.\} and Evers, \{Silvia M. M. A.\} and Tim Frenzel and \{de Geus-Bosma\}, Madeleen and Judith Gillis and \{van der Horst\}, \{Iwan C. C.\} and Koek, \{W. Nadia H.\} and Kitty Linssen and Meex, \{Steven J. R.\} and Mostard, \{Guy J. M.\} and Mostard, \{Remy L. M.\} and Otterspoor, \{Luuk C.\} and \{van Riel\}, \{Natal A. W.\} and Frans Stals and \{van Westreenen\}, Harro and Albert Wolthuis and \{van Mastrigt\}, Ghislaine and Andrea Peeters",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

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doi = "10.1038/s41598-024-58727-y",

language = "English",

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Schoenmakers, T, Leers, MPG, Gorissen, SHM, van Loo, IHM, van Rosmalen, F, Aydeniz, E, Schellens, J, Driessen, M, Deneer, R, de Venne, WPHGV, Wolffs, PFG, van Mook, WNKA, van Bussel, BCT, Ament, S, Arbous, MS, Bekers, O, van Berckel, M, Boer, A-K, van Dam, DW, Deneer, R, van Doorn, WPTM, Dormans, TP, Evers, SMMA, Frenzel, T, de Geus-Bosma, M, Gillis, J, van der Horst, ICC, Koek, WNH, Linssen, K, Meex, SJR, Mostard, GJM, Mostard, RLM, Otterspoor, LC, van Riel, NAW, Stals, F, van Westreenen, H, Wolthuis, A, van Mastrigt, G & Peeters, A 2024, 'The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study', Scientific reports, vol. 14, no. 1, 8220. https://doi.org/10.1038/s41598-024-58727-y

TY - JOUR

T1 - The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time

T2 - a prospective cohort study

AU - Schoenmakers, Tom

AU - Leers, Mathie P. G.

AU - Gorissen, Stefan H. M.

AU - van Loo, Inge H. M.

AU - van Rosmalen, Frank

AU - Aydeniz, Eda

AU - Schellens, Joep

AU - Driessen, Marielle

AU - Deneer, Ruben

AU - de Venne, Wilhelmine P. H. G. Verboeket-van

AU - Wolffs, Petra F. G.

AU - van Mook, Walther N. K. A.

AU - van Bussel, Bas C. T.

AU - Ament, Stephanie

AU - Arbous, M. Sesmu

AU - Bekers, Otto

AU - van Berckel, Miranda

AU - Boer, Arjan-Kars

AU - van Dam, Dirk W.

AU - Deneer, Ruben

AU - van Doorn, William P. T. M.

AU - Dormans, Tom P.

AU - Evers, Silvia M. M. A.

AU - Frenzel, Tim

AU - de Geus-Bosma, Madeleen

AU - Gillis, Judith

AU - van der Horst, Iwan C. C.

AU - Koek, W. Nadia H.

AU - Linssen, Kitty

AU - Meex, Steven J. R.

AU - Mostard, Guy J. M.

AU - Mostard, Remy L. M.

AU - Otterspoor, Luuk C.

AU - van Riel, Natal A. W.

AU - Stals, Frans

AU - van Westreenen, Harro

AU - Wolthuis, Albert

AU - van Mastrigt, Ghislaine

AU - Peeters, Andrea

PY - 2024/12/1

Y1 - 2024/12/1

N2 - The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.

AB - The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.

KW - COVID-19

KW - CoLab score

KW - Linear mixed-effects models

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85189795688

U2 - 10.1038/s41598-024-58727-y

DO - 10.1038/s41598-024-58727-y

M3 - Article

C2 - 38589581

SN - 2045-2322

VL - 14

JO - Scientific reports

JF - Scientific reports

IS - 1

M1 - 8220

ER -

The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study

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Keywords

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