The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts

M. Alders; M. Hodges; A. K. Hadjantonakis; J. Postmus; I. van Wijk; J. Bliek; M. de Meulemeester; A. Westerveld; F. Guillemot; C. Oudejans; P. Little; M. Mannens

doi:10.1093/hmg/6.6.859

The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts

M. Alders
, M. Hodges
, A. K. Hadjantonakis
, J. Postmus
, I. van Wijk
, J. Bliek
, M. de Meulemeester
, A. Westerveld
, F. Guillemot
, C. Oudejans
, P. Little
, M. Mannens

University of Amsterdam
Imperial College London
Institut national de la santé et de la recherche médicale

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man

Original language	English
Pages (from-to)	859-867
Number of pages	9
Journal	Human molecular genetics
Volume	6
Issue number	6
DOIs	https://doi.org/10.1093/hmg/6.6.859
Publication status	Published - 1 Jun 1997

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Alders, M., Hodges, M., Hadjantonakis, A. K., Postmus, J., van Wijk, I., Bliek, J., de Meulemeester, M., Westerveld, A., Guillemot, F., Oudejans, C., Little, P., & Mannens, M. (1997). The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts. Human molecular genetics, 6(6), 859-867. https://doi.org/10.1093/hmg/6.6.859

@article{1cdcce14e8434c27a19529eb2e2343a9,

title = "The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts",

abstract = "Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man",

author = "M. Alders and M. Hodges and Hadjantonakis, \{A. K.\} and J. Postmus and \{van Wijk\}, I. and J. Bliek and \{de Meulemeester\}, M. and A. Westerveld and F. Guillemot and C. Oudejans and P. Little and M. Mannens",

year = "1997",

month = jun,

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doi = "10.1093/hmg/6.6.859",

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Alders, M, Hodges, M, Hadjantonakis, AK, Postmus, J, van Wijk, I , Bliek, J, de Meulemeester, M, Westerveld, A, Guillemot, F, Oudejans, C, Little, P & Mannens, M 1997, 'The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts', Human molecular genetics, vol. 6, no. 6, pp. 859-867. https://doi.org/10.1093/hmg/6.6.859

TY - JOUR

T1 - The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts

AU - Alders, M.

AU - Hodges, M.

AU - Hadjantonakis, A. K.

AU - Postmus, J.

AU - van Wijk, I.

AU - Bliek, J.

AU - de Meulemeester, M.

AU - Westerveld, A.

AU - Guillemot, F.

AU - Oudejans, C.

AU - Little, P.

AU - Mannens, M.

PY - 1997/6/1

Y1 - 1997/6/1

N2 - Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man

AB - Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man

UR - https://www.scopus.com/pages/publications/8244224533

U2 - 10.1093/hmg/6.6.859

DO - 10.1093/hmg/6.6.859

M3 - Article

C2 - 9175731

SN - 0964-6906

VL - 6

SP - 859

EP - 867

JO - Human molecular genetics

JF - Human molecular genetics

IS - 6

ER -

The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts

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