The histamine H4 receptor as a new therapeutic target for inflammation

Iwan J.P. De Esch; Robin L. Thurmond; Aldo Jongejan; Rob Leurs

doi:10.1016/j.tips.2005.07.002

The histamine H₄ receptor as a new therapeutic target for inflammation

Iwan J.P. De Esch
, Robin L. Thurmond
, Aldo Jongejan
, Rob Leurs^*

^*Corresponding author for this work

Vrije Universiteit Amsterdam
Johnson & Johnson

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H₄ receptor has a distinct pharmacological profile and the first compounds that act selectively on the H₄ receptor have been developed. Initial experiments in vivo with H₄ receptor antagonists indicate a role for the H₄ receptor in inflammatory conditions.

Original language	English
Pages (from-to)	462-469
Number of pages	8
Journal	Trends in pharmacological sciences
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.tips.2005.07.002
Publication status	Published - Sept 2005

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10.1016/j.tips.2005.07.002

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title = "The histamine H4 receptor as a new therapeutic target for inflammation",

abstract = "Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H4 receptor have been developed. Initial experiments in vivo with H4 receptor antagonists indicate a role for the H4 receptor in inflammatory conditions.",

author = "\{De Esch\}, \{Iwan J.P.\} and Thurmond, \{Robin L.\} and Aldo Jongejan and Rob Leurs",

year = "2005",

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AU - De Esch, Iwan J.P.

AU - Thurmond, Robin L.

AU - Jongejan, Aldo

AU - Leurs, Rob

PY - 2005/9

Y1 - 2005/9

N2 - Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H4 receptor have been developed. Initial experiments in vivo with H4 receptor antagonists indicate a role for the H4 receptor in inflammatory conditions.

AB - Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H4 receptor have been developed. Initial experiments in vivo with H4 receptor antagonists indicate a role for the H4 receptor in inflammatory conditions.

UR - https://www.scopus.com/pages/publications/23944456700

U2 - 10.1016/j.tips.2005.07.002

DO - 10.1016/j.tips.2005.07.002

M3 - Review article

C2 - 16054239

SN - 0165-6147

VL - 26

SP - 462

EP - 469

JO - Trends in pharmacological sciences

JF - Trends in pharmacological sciences

IS - 9

ER -

The histamine H₄ receptor as a new therapeutic target for inflammation

Abstract

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