The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

A. B. Oestreicher; J. M. Rozemuller; W. H. Gispen

The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

A. B. Oestreicher^*
, J. M. Rozemuller
, W. H. Gispen

^*Corresponding author for this work

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.

Original language	English
Journal	NEUROSCIENCE RESEARCH COMMUNICATIONS
Volume	12
Issue number	SUPPL. 1
Publication status	Published - 1 Jan 1993

Keywords

β-amyloid/A4 protein
Dystrophic neurites
Growth-associated proteins
Neuritic plaques

Cite this

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title = "The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques",

abstract = "The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.",

keywords = "β-amyloid/A4 protein, Dystrophic neurites, Growth-associated proteins, Neuritic plaques",

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T1 - The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

AU - Oestreicher, A. B.

AU - Rozemuller, J. M.

AU - Gispen, W. H.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.

AB - The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.

KW - β-amyloid/A4 protein

KW - Dystrophic neurites

KW - Growth-associated proteins

KW - Neuritic plaques

UR - https://www.scopus.com/pages/publications/0027305080

M3 - Article

SN - 0893-6609

VL - 12

JO - NEUROSCIENCE RESEARCH COMMUNICATIONS

JF - NEUROSCIENCE RESEARCH COMMUNICATIONS

IS - SUPPL. 1

ER -

The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

Abstract

Keywords

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