The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress

Stephanie B. Dixon; Eric J. Chow; Lars Hjorth; Melissa M. Hudson; Leontien C. M. Kremer; Lindsay M. Morton; Paul C. Nathan; Kirsten K. Ness; Kevin C. Oeffinger; Gregory T. Armstrong

doi:10.1016/j.pcl.2020.07.013

The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress

Stephanie B. Dixon^*
, Eric J. Chow
, Lars Hjorth
, Melissa M. Hudson
, Leontien C. M. Kremer
, Lindsay M. Morton
, Paul C. Nathan
, Kirsten K. Ness
, Kevin C. Oeffinger
, Gregory T. Armstrong

^*Corresponding author for this work

St. Jude Children Research Hospital
University of Washington
Lund University
Dutch Childhood Oncology Group (DCOG), Princess Máxima Centre, Utrecht, The Netherlands
National Institutes of Health
University of Toronto
Duke University

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.

Original language	English
Pages (from-to)	1237-1251
Number of pages	15
Journal	Pediatric clinics of North America
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.pcl.2020.07.013
Publication status	Published - 1 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescent
Cancer
Child
Delivery of health care
Neoplasms
Survivor
Treatment outcome

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10.1016/j.pcl.2020.07.013

Cite this

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title = "The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress",

abstract = "As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.",

keywords = "Adolescent, Cancer, Child, Delivery of health care, Neoplasms, Survivor, Treatment outcome",

author = "Dixon, \{Stephanie B.\} and Chow, \{Eric J.\} and Lars Hjorth and Hudson, \{Melissa M.\} and Kremer, \{Leontien C. M.\} and Morton, \{Lindsay M.\} and Nathan, \{Paul C.\} and Ness, \{Kirsten K.\} and Oeffinger, \{Kevin C.\} and Armstrong, \{Gregory T.\}",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.pcl.2020.07.013",

language = "English",

volume = "67",

pages = "1237--1251",

journal = "Pediatric clinics of North America",

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}

TY - JOUR

T1 - The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress

AU - Dixon, Stephanie B.

AU - Chow, Eric J.

AU - Hjorth, Lars

AU - Hudson, Melissa M.

AU - Kremer, Leontien C. M.

AU - Morton, Lindsay M.

AU - Nathan, Paul C.

AU - Ness, Kirsten K.

AU - Oeffinger, Kevin C.

AU - Armstrong, Gregory T.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.

AB - As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.

KW - Adolescent

KW - Cancer

KW - Child

KW - Delivery of health care

KW - Neoplasms

KW - Survivor

KW - Treatment outcome

UR - https://www.scopus.com/pages/publications/85094202228

U2 - 10.1016/j.pcl.2020.07.013

DO - 10.1016/j.pcl.2020.07.013

M3 - Review article

C2 - 33131544

SN - 0031-3955

VL - 67

SP - 1237

EP - 1251

JO - Pediatric clinics of North America

JF - Pediatric clinics of North America

IS - 6

ER -

The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress

Abstract

UN SDGs

Keywords

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