The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods

Penelope A. Phillips-Howard, Feiko O. ter Kuile, Bernard L. Nahlen, Jane A. Alaii, John E. Gimnig, Margarette S. Kolczak, Dianne J. Terlouw, Simon K. Kariuki, Ya Ping Shi, S. Patrick Kachur, Allen W. Hightower, John M. Vulule, William A. Hawley

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Abstract

This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed
Original languageEnglish
Pages (from-to)10-15
JournalAmerican journal of tropical medicine and hygiene
Volume68
Issue number4 Suppl
Publication statusPublished - 2003

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