The effects of the pericardium on length-dependent regulation of left ventricular function in coronary artery surgery patients

S. G. de Hert; P. W. ten Broecke; I. E. Rodrigus; E. Mertens; B. A. Stockman; K. M. Vermeyen

doi:10.1053/jcan.2001.23273

The effects of the pericardium on length-dependent regulation of left ventricular function in coronary artery surgery patients

S. G. de Hert
, P. W. ten Broecke
, I. E. Rodrigus
, E. Mertens
, B. A. Stockman
, K. M. Vermeyen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To analyze the effects of the pericardium on the length-dependent regulation of myocardial function in coronary artery surgery patients. DESIGN: Prospective. SETTING: University hospital. PARTICIPANTS: Patients scheduled for elective coronary artery surgery. INTERVENTIONS: In 10 patients, a combined micromanometer transducer conductance catheter was inserted into the left ventricle for measurement of left ventricular pressures and volumes. MEASUREMENTS AND MAIN RESULTS: Consecutive data were obtained during a progressive increase in left ventricular pressures and volumes obtained by leg elevation in closed chest-closed pericardium and open chest-open pericardium conditions. Pericardiotomy did not alter baseline left ventricular hemodynamics. The effects of leg elevation were different, however. In closed chest-closed pericardium conditions, stroke volume and stroke work remained unchanged, whereas these parameters increased in open chest-open pericardium conditions. This increase was related to the increase in end-diastolic volume that was observed in open chest-open pericardium conditions and not in closed chest-closed pericardium conditions. CONCLUSIONS: In coronary artery surgery patients, pericardiotomy does not alter baseline left ventricular function. When cardiac load is increased by leg elevation, however, use of the Frank-Starling mechanism is enhanced in open chest-open pericardium conditions

Original language	English
Pages (from-to)	300-305
Journal	Journal of cardiothoracic and vascular anesthesia
Volume	15
Issue number	3
DOIs	https://doi.org/10.1053/jcan.2001.23273
Publication status	Published - 2001

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10.1053/jcan.2001.23273

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@article{b296f57d40014ba3ae54cad7ffdd441a,

title = "The effects of the pericardium on length-dependent regulation of left ventricular function in coronary artery surgery patients",

abstract = "OBJECTIVE: To analyze the effects of the pericardium on the length-dependent regulation of myocardial function in coronary artery surgery patients. DESIGN: Prospective. SETTING: University hospital. PARTICIPANTS: Patients scheduled for elective coronary artery surgery. INTERVENTIONS: In 10 patients, a combined micromanometer transducer conductance catheter was inserted into the left ventricle for measurement of left ventricular pressures and volumes. MEASUREMENTS AND MAIN RESULTS: Consecutive data were obtained during a progressive increase in left ventricular pressures and volumes obtained by leg elevation in closed chest-closed pericardium and open chest-open pericardium conditions. Pericardiotomy did not alter baseline left ventricular hemodynamics. The effects of leg elevation were different, however. In closed chest-closed pericardium conditions, stroke volume and stroke work remained unchanged, whereas these parameters increased in open chest-open pericardium conditions. This increase was related to the increase in end-diastolic volume that was observed in open chest-open pericardium conditions and not in closed chest-closed pericardium conditions. CONCLUSIONS: In coronary artery surgery patients, pericardiotomy does not alter baseline left ventricular function. When cardiac load is increased by leg elevation, however, use of the Frank-Starling mechanism is enhanced in open chest-open pericardium conditions",

author = "\{de Hert\}, \{S. G.\} and \{ten Broecke\}, \{P. W.\} and Rodrigus, \{I. E.\} and E. Mertens and Stockman, \{B. A.\} and Vermeyen, \{K. M.\}",

year = "2001",

doi = "10.1053/jcan.2001.23273",

language = "English",

volume = "15",

pages = "300--305",

journal = "Journal of cardiothoracic and vascular anesthesia",

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TY - JOUR

T1 - The effects of the pericardium on length-dependent regulation of left ventricular function in coronary artery surgery patients

AU - de Hert, S. G.

AU - ten Broecke, P. W.

AU - Rodrigus, I. E.

AU - Mertens, E.

AU - Stockman, B. A.

AU - Vermeyen, K. M.

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: To analyze the effects of the pericardium on the length-dependent regulation of myocardial function in coronary artery surgery patients. DESIGN: Prospective. SETTING: University hospital. PARTICIPANTS: Patients scheduled for elective coronary artery surgery. INTERVENTIONS: In 10 patients, a combined micromanometer transducer conductance catheter was inserted into the left ventricle for measurement of left ventricular pressures and volumes. MEASUREMENTS AND MAIN RESULTS: Consecutive data were obtained during a progressive increase in left ventricular pressures and volumes obtained by leg elevation in closed chest-closed pericardium and open chest-open pericardium conditions. Pericardiotomy did not alter baseline left ventricular hemodynamics. The effects of leg elevation were different, however. In closed chest-closed pericardium conditions, stroke volume and stroke work remained unchanged, whereas these parameters increased in open chest-open pericardium conditions. This increase was related to the increase in end-diastolic volume that was observed in open chest-open pericardium conditions and not in closed chest-closed pericardium conditions. CONCLUSIONS: In coronary artery surgery patients, pericardiotomy does not alter baseline left ventricular function. When cardiac load is increased by leg elevation, however, use of the Frank-Starling mechanism is enhanced in open chest-open pericardium conditions

AB - OBJECTIVE: To analyze the effects of the pericardium on the length-dependent regulation of myocardial function in coronary artery surgery patients. DESIGN: Prospective. SETTING: University hospital. PARTICIPANTS: Patients scheduled for elective coronary artery surgery. INTERVENTIONS: In 10 patients, a combined micromanometer transducer conductance catheter was inserted into the left ventricle for measurement of left ventricular pressures and volumes. MEASUREMENTS AND MAIN RESULTS: Consecutive data were obtained during a progressive increase in left ventricular pressures and volumes obtained by leg elevation in closed chest-closed pericardium and open chest-open pericardium conditions. Pericardiotomy did not alter baseline left ventricular hemodynamics. The effects of leg elevation were different, however. In closed chest-closed pericardium conditions, stroke volume and stroke work remained unchanged, whereas these parameters increased in open chest-open pericardium conditions. This increase was related to the increase in end-diastolic volume that was observed in open chest-open pericardium conditions and not in closed chest-closed pericardium conditions. CONCLUSIONS: In coronary artery surgery patients, pericardiotomy does not alter baseline left ventricular function. When cardiac load is increased by leg elevation, however, use of the Frank-Starling mechanism is enhanced in open chest-open pericardium conditions

U2 - 10.1053/jcan.2001.23273

DO - 10.1053/jcan.2001.23273

M3 - Article

C2 - 11426359

SN - 1053-0770

VL - 15

SP - 300

EP - 305

JO - Journal of cardiothoracic and vascular anesthesia

JF - Journal of cardiothoracic and vascular anesthesia

IS - 3

ER -

The effects of the pericardium on length-dependent regulation of left ventricular function in coronary artery surgery patients

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