The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities

Ivan Vujkovic-Cvijin; Ornella Sortino; Eveline Verheij; Ferdinand W. Wit; Neeltje A. Kootstra; Brian Sellers; Maarten Schim van der Loeff; Yasmine Belkaid; Peter Reiss; Irini Sereti

doi:10.1093/infdis/jiab096

The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities

Ivan Vujkovic-Cvijin
, Ornella Sortino
, Eveline Verheij
, Ferdinand W. Wit
, Neeltje A. Kootstra
, Brian Sellers
, Maarten Schim van der Loeff
, Yasmine Belkaid
, Peter Reiss
, Irini Sereti^*

^*Corresponding author for this work

National Institutes of Health
Municipal Health Service of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

Original language	English
Pages (from-to)	1405-1409
Number of pages	5
Journal	Journal of infectious diseases
Volume	224
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiab096
Publication status	Published - 15 Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
biomarker
comorbidities
complement
noncommunicable diseases

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10.1093/infdis/jiab096

The-complement-pathway-is-activated-in-people-with-human-immunodeficiency-virus-and-is-associated-with-non-aids-comorbid.pdfFinal published version, 377 KBLicence: CC BY

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Vujkovic-Cvijin, I., Sortino, O., Verheij, E., Wit, F. W., Kootstra, N. A., Sellers, B., Schim van der Loeff, M., Belkaid, Y., Reiss, P., & Sereti, I. (2021). The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities. Journal of infectious diseases, 224(8), 1405-1409. https://doi.org/10.1093/infdis/jiab096

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title = "The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities",

abstract = "Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.",

keywords = "HIV, biomarker, comorbidities, complement, noncommunicable diseases",

author = "Ivan Vujkovic-Cvijin and Ornella Sortino and Eveline Verheij and Wit, \{Ferdinand W.\} and Kootstra, \{Neeltje A.\} and Brian Sellers and \{Schim van der Loeff\}, Maarten and Yasmine Belkaid and Peter Reiss and Irini Sereti",

note = "Publisher Copyright: {\textcopyright} 2021 Published by Oxford University Press for the Infectious Diseases Society of America 2021.",

year = "2021",

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doi = "10.1093/infdis/jiab096",

language = "English",

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Vujkovic-Cvijin, I, Sortino, O, Verheij, E , Wit, FW , Kootstra, NA, Sellers, B, Schim van der Loeff, M, Belkaid, Y, Reiss, P & Sereti, I 2021, 'The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities', Journal of infectious diseases, vol. 224, no. 8, pp. 1405-1409. https://doi.org/10.1093/infdis/jiab096

TY - JOUR

T1 - The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities

AU - Vujkovic-Cvijin, Ivan

AU - Sortino, Ornella

AU - Verheij, Eveline

AU - Wit, Ferdinand W.

AU - Kootstra, Neeltje A.

AU - Sellers, Brian

AU - Schim van der Loeff, Maarten

AU - Belkaid, Yasmine

AU - Reiss, Peter

AU - Sereti, Irini

PY - 2021/10/15

Y1 - 2021/10/15

N2 - Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

AB - Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

KW - HIV

KW - biomarker

KW - comorbidities

KW - complement

KW - noncommunicable diseases

UR - https://www.scopus.com/pages/publications/85113317747

U2 - 10.1093/infdis/jiab096

DO - 10.1093/infdis/jiab096

M3 - Article

C2 - 33606018

SN - 0022-1899

VL - 224

SP - 1405

EP - 1409

JO - Journal of infectious diseases

JF - Journal of infectious diseases

IS - 8

ER -

The Complement Pathway Is Activated in People with Human Immunodeficiency Virus and Is Associated with Non-AIDS Comorbidities

Abstract

UN SDGs

Keywords

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