Abstract
Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.
| Original language | English |
|---|---|
| Pages (from-to) | 593-8 |
| Number of pages | 6 |
| Journal | Journal of Neural Transmission |
| Volume | 113 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2006 |
Keywords
- Analysis of Variance
- Anethole Trithione
- Animals
- Animals, Newborn
- Antioxidants
- Astrocytes
- Basal Ganglia
- Cells, Cultured
- Clorgyline
- Dose-Response Relationship, Drug
- Enzyme Activation
- Monoamine Oxidase
- Monoamine Oxidase Inhibitors
- Rats
- Comparative Study
- Journal Article
Fingerprint
Dive into the research topics of 'The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver