TY - JOUR
T1 - The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19
AU - Vlaar, Alexander P J
AU - Lim, Endry H T
AU - de Bruin, Sanne
AU - Rückinger, Simon
AU - Pilz, Korinna
AU - Brouwer, Matthijs C
AU - Guo, Ren-Feng
AU - Heunks, Leo M A
AU - Busch, Matthias H
AU - van Paassen, Pieter
AU - Riedemann, Niels C
AU - van de Beek, Diederik
N1 - Funding Information:
The trial was funded by InflaRx. A.P.J.V. reports personal fees from InflaRx, paid to Amsterdam UMC, during the conduct of the study
Funding Information:
The trial was funded by InflaRx. A.P.J.V. reports personal fees from InflaRx, paid to Amsterdam UMC, during the conduct of the study The trial was designed by InflaRx representatives and academic advisors. Data were collected by investigators and associated site personnel, analyzed by statisticians employed by Metronomia, and interpreted by academic authors and InflaRx representatives. A.P.J.V., E.H.T.L., S.R., N.C.R., K.P., and D.B. take responsibility for the integrity of the data and the accuracy of the data analysis. All authors had full access to the data, and vouch for the completeness and accuracy of the data. The first draft of the manuscript was written by A.P.J.V., E.H.T.L., and D.B. with input from authors employed by InflaRx.
Publisher Copyright:
© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
PY - 2022/4
Y1 - 2022/4
N2 - Recently, we reported the phase II portion of the adaptive phase II/III PANAMO trial exploring potential benefit and safety of selectively blocking C5a with the monoclonal antibody vilobelimab (IFX-1) in patients with severe coronavirus disease 2019 (COVID-19). The potent anaphylatoxin C5a attracts neutrophils and monocytes to the infection site, causes tissue damage by oxidative radical formation and enzyme releases, and leads to activation of the coagulation system. Results demonstrated that C5a inhibition with vilobelimab was safe and secondary outcomes appeared in favor of vilobelimab. We now report the pharmacokinetic/pharmacodynamic (PK/PD) analysis of the phase II study. Between March 31 and April 24, 2020, 30 patients with severe COVID-19 pneumonia confirmed by real-time polymerase chain reaction were randomly assigned 1:1 to receive vilobelimab plus best supportive care or best supportive care only. Samples for measurement of vilobelimab, C3a and C5a blood concentrations were taken. Vilobelimab predose (trough) drug concentrations in plasma ranged from 84,846 to 248,592 ng/ml (571 to 1674 nM) with a geometric mean of 151,702 ng/ml (1022 nM) on day 2 and from 80,060 to 200,746 ng/ml (539 to 1352 nM) with a geometric mean of 139,503 ng/ml (939 nM) on day 8. After the first vilobelimab infusion, C5a concentrations were suppressed in the vilobelimab group (median 39.70 ng/ml 4.8 nM, IQR 33.20-45.55) as compared to the control group (median 158.53 ng/ml 19.1 nM, IQR 60.03-200.89, p = 0.0006). The suppression was maintained on day 8 (p = 0.001). The current PK/PD analysis shows that vilobelimab efficiently inhibits C5a in patients with severe COVID-19.
AB - Recently, we reported the phase II portion of the adaptive phase II/III PANAMO trial exploring potential benefit and safety of selectively blocking C5a with the monoclonal antibody vilobelimab (IFX-1) in patients with severe coronavirus disease 2019 (COVID-19). The potent anaphylatoxin C5a attracts neutrophils and monocytes to the infection site, causes tissue damage by oxidative radical formation and enzyme releases, and leads to activation of the coagulation system. Results demonstrated that C5a inhibition with vilobelimab was safe and secondary outcomes appeared in favor of vilobelimab. We now report the pharmacokinetic/pharmacodynamic (PK/PD) analysis of the phase II study. Between March 31 and April 24, 2020, 30 patients with severe COVID-19 pneumonia confirmed by real-time polymerase chain reaction were randomly assigned 1:1 to receive vilobelimab plus best supportive care or best supportive care only. Samples for measurement of vilobelimab, C3a and C5a blood concentrations were taken. Vilobelimab predose (trough) drug concentrations in plasma ranged from 84,846 to 248,592 ng/ml (571 to 1674 nM) with a geometric mean of 151,702 ng/ml (1022 nM) on day 2 and from 80,060 to 200,746 ng/ml (539 to 1352 nM) with a geometric mean of 139,503 ng/ml (939 nM) on day 8. After the first vilobelimab infusion, C5a concentrations were suppressed in the vilobelimab group (median 39.70 ng/ml 4.8 nM, IQR 33.20-45.55) as compared to the control group (median 158.53 ng/ml 19.1 nM, IQR 60.03-200.89, p = 0.0006). The suppression was maintained on day 8 (p = 0.001). The current PK/PD analysis shows that vilobelimab efficiently inhibits C5a in patients with severe COVID-19.
UR - https://www.scopus.com/pages/publications/85122751427
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122751427&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35029045
U2 - 10.1111/cts.13213
DO - 10.1111/cts.13213
M3 - Article
C2 - 35029045
SN - 1752-8054
VL - 15
SP - 854
EP - 858
JO - CTS-CLINICAL AND TRANSLATIONAL SCIENCE
JF - CTS-CLINICAL AND TRANSLATIONAL SCIENCE
IS - 4
ER -
SDG 3 Good Health and Well-being