The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors

Geor Bakker; Nora Chekrouni; Wilhelmina A. M. Vingerhoets; Jan-Peter van Wieringen; Kora de Bruin; Jos Eersels; Jan de Jong; Youssef Chahid; Oswald J. Bloemen; Thérèse A. van Amelsvoort; Jan Booij

doi:10.14800/rci.1163

The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors

Geor Bakker
, Nora Chekrouni
, Wilhelmina A. M. Vingerhoets
, Jan-Peter van Wieringen
, Kora de Bruin
, Jos Eersels
, Jan de Jong
, Youssef Chahid
, Oswald J. Bloemen
, Thérèse A. van Amelsvoort
, Jan Booij

Research output: Contribution to journal › Article › Professional

Original language	English
Article number	e1163
Number of pages	6
Journal	Receptors & Clinical Investigation
Volume	3
Issue number	1
DOIs	https://doi.org/10.14800/rci.1163
Publication status	Published - 25 Jan 2016

Keywords

123I-iododexetimide; SPECT; muscarinic M1 receptor agonist; xanomeline; cognition; rat

Access to Document

10.14800/rci.1163

Cite this

Bakker, G., Chekrouni, N., Vingerhoets, W. A. M., van Wieringen, J.-P., de Bruin, K., Eersels, J., de Jong, J., Chahid, Y., Bloemen, O. J., van Amelsvoort, T. A., & Booij, J. (2016). The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors. Receptors & Clinical Investigation, 3(1), Article e1163. https://doi.org/10.14800/rci.1163

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keywords = "123I-iododexetimide; SPECT; muscarinic M1 receptor agonist; xanomeline; cognition; rat",

author = "Geor Bakker and Nora Chekrouni and Vingerhoets, \{Wilhelmina A. M.\} and \{van Wieringen\}, Jan-Peter and \{de Bruin\}, Kora and Jos Eersels and \{de Jong\}, Jan and Youssef Chahid and Bloemen, \{Oswald J.\} and \{van Amelsvoort\}, \{Th{\'e}r{\`e}se A.\} and Jan Booij",

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day = "25",

doi = "10.14800/rci.1163",

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Bakker, G, Chekrouni, N, Vingerhoets, WAM, van Wieringen, J-P, de Bruin, K, Eersels, J, de Jong, J, Chahid, Y, Bloemen, OJ, van Amelsvoort, TA & Booij, J 2016, 'The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors', Receptors & Clinical Investigation, vol. 3, no. 1, e1163. https://doi.org/10.14800/rci.1163

The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors. / Bakker, Geor; Chekrouni, Nora; Vingerhoets, Wilhelmina A. M. et al.
In: Receptors & Clinical Investigation, Vol. 3, No. 1, e1163, 25.01.2016.

Research output: Contribution to journal › Article › Professional

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T1 - The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors

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AU - Vingerhoets, Wilhelmina A. M.

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AU - de Jong, Jan

AU - Chahid, Youssef

AU - Bloemen, Oswald J.

AU - van Amelsvoort, Thérèse A.

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Bakker G, Chekrouni N, Vingerhoets WAM, van Wieringen JP, de Bruin K, Eersels J et al. The antagonist SPECT tracer 123I-iododexetimide binds preferentially to the muscarinic M1 receptor in-vivo, but is it also a potential tool to assess the occupancy of muscarinic M1 receptors by agonists? Receptors. Receptors & Clinical Investigation. 2016 Jan 25;3(1):e1163. doi: 10.14800/rci.1163