Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens

N. P. Juffermans; A. Verbon; M. J. Schultz; C. E. Hack; S. J. van Deventer; P. Speelman; T. van der Poll

doi:10.1128/AAC.45.5.1547-1549.2001

Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens

N. P. Juffermans
, A. Verbon
, M. J. Schultz
, C. E. Hack
, S. J. van Deventer
, P. Speelman
, T. van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ingestion of thalidomide was associated with a reduction in the upregulation of the granulocyte activation marker CD11b and a reduced capacity to release elastase and lactoferrin after stimulation with lipopolysaccharide or lipoteichoic acid. A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens

Original language	English
Pages (from-to)	1547-1549
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	5
DOIs	https://doi.org/10.1128/AAC.45.5.1547-1549.2001
Publication status	Published - 2001

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10.1128/AAC.45.5.1547-1549.2001

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title = "Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens",

abstract = "Ingestion of thalidomide was associated with a reduction in the upregulation of the granulocyte activation marker CD11b and a reduced capacity to release elastase and lactoferrin after stimulation with lipopolysaccharide or lipoteichoic acid. A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens",

author = "Juffermans, \{N. P.\} and A. Verbon and Schultz, \{M. J.\} and Hack, \{C. E.\} and \{van Deventer\}, \{S. J.\} and P. Speelman and \{van der Poll\}, T.",

year = "2001",

doi = "10.1128/AAC.45.5.1547-1549.2001",

language = "English",

volume = "45",

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journal = "Antimicrobial agents and chemotherapy",

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publisher = "American Society for Microbiology",

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T1 - Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens

AU - Juffermans, N. P.

AU - Verbon, A.

AU - Schultz, M. J.

AU - Hack, C. E.

AU - van Deventer, S. J.

AU - Speelman, P.

AU - van der Poll, T.

PY - 2001

Y1 - 2001

N2 - Ingestion of thalidomide was associated with a reduction in the upregulation of the granulocyte activation marker CD11b and a reduced capacity to release elastase and lactoferrin after stimulation with lipopolysaccharide or lipoteichoic acid. A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens

AB - Ingestion of thalidomide was associated with a reduction in the upregulation of the granulocyte activation marker CD11b and a reduced capacity to release elastase and lactoferrin after stimulation with lipopolysaccharide or lipoteichoic acid. A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens

U2 - 10.1128/AAC.45.5.1547-1549.2001

DO - 10.1128/AAC.45.5.1547-1549.2001

M3 - Article

C2 - 11302825

SN - 0066-4804

VL - 45

SP - 1547

EP - 1549

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 5

ER -

Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens

Abstract

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