Taxanes: A new class of antitumor agents

M. T. Huizing; V. H. Sewberath Misser; R. C. Pieters; W. W. ten Bokkel Huinink; C. H. N. Veenhof; J. B. Vermorken; H. M. Pinedo; J. H. Beijnen

doi:10.3109/07357909509031919

Taxanes: A new class of antitumor agents

M. T. Huizing^*
, V. H. Sewberath Misser
, R. C. Pieters
, W. W. ten Bokkel Huinink
, C. H. N. Veenhof
, J. B. Vermorken
, H. M. Pinedo
, J. H. Beijnen

^*Corresponding author for this work

Slotervaart Hospital
Netherlands Cancer Institute
Amsterdam UMC - University of Amsterdam
Amsterdam UMC - Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Original language	English
Pages (from-to)	381-404
Journal	Cancer investigation
Volume	13
Issue number	4
DOIs	https://doi.org/10.3109/07357909509031919
Publication status	Published - 1995
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.3109/07357909509031919

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title = "Taxanes: A new class of antitumor agents",

abstract = "Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes. {\textcopyright} 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.",

author = "Huizing, \{M. T.\} and Misser, \{V. H. Sewberath\} and Pieters, \{R. C.\} and \{ten Bokkel Huinink\}, \{W. W.\} and Veenhof, \{C. H. N.\} and Vermorken, \{J. B.\} and Pinedo, \{H. M.\} and Beijnen, \{J. H.\}",

year = "1995",

doi = "10.3109/07357909509031919",

language = "English",

volume = "13",

pages = "381--404",

journal = "Cancer investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

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}

TY - JOUR

T1 - Taxanes

T2 - A new class of antitumor agents

AU - Huizing, M. T.

AU - Misser, V. H. Sewberath

AU - Pieters, R. C.

AU - ten Bokkel Huinink, W. W.

AU - Veenhof, C. H. N.

AU - Vermorken, J. B.

AU - Pinedo, H. M.

AU - Beijnen, J. H.

PY - 1995

Y1 - 1995

N2 - Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

AB - Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

UR - https://www.scopus.com/pages/publications/0029100273

UR - https://www.ncbi.nlm.nih.gov/pubmed/7627725

U2 - 10.3109/07357909509031919

DO - 10.3109/07357909509031919

M3 - Article

C2 - 7627725

SN - 0735-7907

VL - 13

SP - 381

EP - 404

JO - Cancer investigation

JF - Cancer investigation

IS - 4

ER -

Taxanes: A new class of antitumor agents

Abstract

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