Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids

Patrick Wisse; Henrik Gold; Mina Mirzaian; Maria J. Ferraz; Ginger Lutteke; Richard J. B. H. N. van den Berg; Hans van den Elst; Johan Lugtenburg; Gijsbert A. van der Marel; Johannes M. F. G. Aerts; Jeroen D. C. Codee; Herman S. Overkleeft

doi:10.1002/ejoc.201500025

Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids

Patrick Wisse
, Henrik Gold
, Mina Mirzaian
, Maria J. Ferraz
, Ginger Lutteke
, Richard J. B. H. N. van den Berg
, Hans van den Elst
, Johan Lugtenburg
, Gijsbert A. van der Marel
, Johannes M. F. G. Aerts
, Jeroen D. C. Codee
, Herman S. Overkleeft

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The synthesis of a focussed library of sphingolipids differing in the number and position of C-13 labels is described. The synthesised sphingolipids differ in substitution at both the sphingosine amine (either palmitoylated or unmodified) and the sphingosine primary hydroxyl (unmodified or glycosylated). Moreover, C-13 atoms are incorporated into either the sphingosine or the palmitate moiety, or both. This set of compounds is intended for use in relative quantitative lipidomics studies to gain insight into sphingolipid metabolism in healthy and diseased (lysosomal storage disorders) patients and animal models

Original language	English
Pages (from-to)	2661-2677
Journal	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume	2015
Issue number	12
DOIs	https://doi.org/10.1002/ejoc.201500025
Publication status	Published - 2015

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Synthesis-of-a-panel-of-carbon-13-labelled-glycosphingolipids.pdfFinal published version, 1.39 MBLicence: Taverne

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Wisse, P., Gold, H., Mirzaian, M., Ferraz, M. J., Lutteke, G., van den Berg, R. J. B. H. N., van den Elst, H., Lugtenburg, J., van der Marel, G. A., Aerts, J. M. F. G., Codee, J. D. C., & Overkleeft, H. S. (2015). Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015(12), 2661-2677. https://doi.org/10.1002/ejoc.201500025

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title = "Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids",

abstract = "The synthesis of a focussed library of sphingolipids differing in the number and position of C-13 labels is described. The synthesised sphingolipids differ in substitution at both the sphingosine amine (either palmitoylated or unmodified) and the sphingosine primary hydroxyl (unmodified or glycosylated). Moreover, C-13 atoms are incorporated into either the sphingosine or the palmitate moiety, or both. This set of compounds is intended for use in relative quantitative lipidomics studies to gain insight into sphingolipid metabolism in healthy and diseased (lysosomal storage disorders) patients and animal models",

author = "Patrick Wisse and Henrik Gold and Mina Mirzaian and Ferraz, \{Maria J.\} and Ginger Lutteke and \{van den Berg\}, \{Richard J. B. H. N.\} and \{van den Elst\}, Hans and Johan Lugtenburg and \{van der Marel\}, \{Gijsbert A.\} and Aerts, \{Johannes M. F. G.\} and Codee, \{Jeroen D. C.\} and Overkleeft, \{Herman S.\}",

year = "2015",

doi = "10.1002/ejoc.201500025",

language = "English",

volume = "2015",

pages = "2661--2677",

journal = "EUROPEAN JOURNAL OF ORGANIC CHEMISTRY",

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T1 - Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids

AU - Wisse, Patrick

AU - Gold, Henrik

AU - Mirzaian, Mina

AU - Ferraz, Maria J.

AU - Lutteke, Ginger

AU - van den Berg, Richard J. B. H. N.

AU - van den Elst, Hans

AU - Lugtenburg, Johan

AU - van der Marel, Gijsbert A.

AU - Aerts, Johannes M. F. G.

AU - Codee, Jeroen D. C.

AU - Overkleeft, Herman S.

PY - 2015

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AB - The synthesis of a focussed library of sphingolipids differing in the number and position of C-13 labels is described. The synthesised sphingolipids differ in substitution at both the sphingosine amine (either palmitoylated or unmodified) and the sphingosine primary hydroxyl (unmodified or glycosylated). Moreover, C-13 atoms are incorporated into either the sphingosine or the palmitate moiety, or both. This set of compounds is intended for use in relative quantitative lipidomics studies to gain insight into sphingolipid metabolism in healthy and diseased (lysosomal storage disorders) patients and animal models

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DO - 10.1002/ejoc.201500025

M3 - Article

SN - 1434-193X

VL - 2015

SP - 2661

EP - 2677

JO - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

JF - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

IS - 12

ER -

Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids

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