Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP: 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)

Andrés Alguacil; Franco Scalambra; Adrián Puerta; Aday González-Bakker; José M. Padrón; Antonio Romerosa

doi:10.1155/bca/4247392

Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP: 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)

Andrés Alguacil
, Franco Scalambra
, Adrián Puerta
, Aday González-Bakker
, José M. Padrón
, Antonio Romerosa^*

^*Corresponding author for this work

University of Almeria
University of La Laguna

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Complexes [RuCp(PPh3)2(HdmoPTA)][PtCl4] (1), [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (2), [RuClCp(PPh3) (HdmoPTA)]2[PtCl4] (3), and [RuClCp(PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)]2[PtCl4] (4) have been synthesized and characterized by NMR, IR, and crystal structure of 2 was obtained by single crystal X-Ray diffraction. Antiproliferative activity of 1 was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI50 values in the submicromolar range.

Original language	English
Article number	4247392
Journal	Bioinorganic Chemistry and Applications
Volume	2025
Issue number	1
DOIs	https://doi.org/10.1155/bca/4247392
Publication status	Published - 2025
Externally published	Yes

Keywords

antiproliferative activity
heterometallic complexes
platinum
ruthenium

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10.1155/bca/4247392

Synthesis-and-study-of-the-ru-pt-heterometallic-complexes-rucpl-pph3--dmopta-1p.pdfFinal published version, 741 KBLicence: CC BY

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@article{a6d5aa6944a84285be5651650428bacb,

title = "Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP: 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)",

abstract = "Complexes [RuCp(PPh3)2(HdmoPTA)][PtCl4] (1), [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (2), [RuClCp(PPh3) (HdmoPTA)]2[PtCl4] (3), and [RuClCp(PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)]2[PtCl4] (4) have been synthesized and characterized by NMR, IR, and crystal structure of 2 was obtained by single crystal X-Ray diffraction. Antiproliferative activity of 1 was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI50 values in the submicromolar range.",

keywords = "antiproliferative activity, heterometallic complexes, platinum, ruthenium",

author = "Andr{\'e}s Alguacil and Franco Scalambra and Adri{\'a}n Puerta and Aday Gonz{\'a}lez-Bakker and Padr{\'o}n, \{Jos{\'e} M.\} and Antonio Romerosa",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Andr{\'e}s Alguacil et al. Bioinorganic Chemistry and Applications published by John Wiley \& Sons Ltd.",

year = "2025",

doi = "10.1155/bca/4247392",

language = "English",

volume = "2025",

journal = "Bioinorganic Chemistry and Applications",

issn = "1565-3633",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP: 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3). / Alguacil, Andrés; Scalambra, Franco; Puerta, Adrián et al.
In: Bioinorganic Chemistry and Applications, Vol. 2025, No. 1, 4247392, 2025.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP

T2 - 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)

AU - Alguacil, Andrés

AU - Scalambra, Franco

AU - Puerta, Adrián

AU - González-Bakker, Aday

AU - Padrón, José M.

AU - Romerosa, Antonio

PY - 2025

Y1 - 2025

N2 - Complexes [RuCp(PPh3)2(HdmoPTA)][PtCl4] (1), [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (2), [RuClCp(PPh3) (HdmoPTA)]2[PtCl4] (3), and [RuClCp(PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)]2[PtCl4] (4) have been synthesized and characterized by NMR, IR, and crystal structure of 2 was obtained by single crystal X-Ray diffraction. Antiproliferative activity of 1 was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI50 values in the submicromolar range.

AB - Complexes [RuCp(PPh3)2(HdmoPTA)][PtCl4] (1), [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (2), [RuClCp(PPh3) (HdmoPTA)]2[PtCl4] (3), and [RuClCp(PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)]2[PtCl4] (4) have been synthesized and characterized by NMR, IR, and crystal structure of 2 was obtained by single crystal X-Ray diffraction. Antiproliferative activity of 1 was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI50 values in the submicromolar range.

KW - antiproliferative activity

KW - heterometallic complexes

KW - platinum

KW - ruthenium

UR - https://www.scopus.com/pages/publications/105020413815

U2 - 10.1155/bca/4247392

DO - 10.1155/bca/4247392

M3 - Article

C2 - 41195161

SN - 1565-3633

VL - 2025

JO - Bioinorganic Chemistry and Applications

JF - Bioinorganic Chemistry and Applications

IS - 1

M1 - 4247392

ER -

Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP: 2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)

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