Survival of patients with ovarian cancer due to a mismatch repair defect

Th E. M. Crijnen; M. L. G. Janssen-Heijnen; H. Gelderblom; J. Morreau; M. A. Nooij; G. G. Kenter; H. F. A. Vasen

doi:10.1007/s10689-005-6573-2

Survival of patients with ovarian cancer due to a mismatch repair defect

Th E. M. Crijnen
, M. L. G. Janssen-Heijnen
, H. Gelderblom
, J. Morreau
, M. A. Nooij
, G. G. Kenter
, H. F. A. Vasen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC-HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC-HNPCC and a control group. METHODS: A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan-Meier analysis was used to calculate the crude survival. RESULTS: The mean age at diagnosis of OC-HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC-HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC-HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1% respectively. CONCLUSION: On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC

Original language	English
Pages (from-to)	301-305
Journal	Familial cancer
Volume	4
Issue number	4
DOIs	https://doi.org/10.1007/s10689-005-6573-2
Publication status	Published - 2005

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@article{f7b739a97a5d405cb04c787d170a4e97,

title = "Survival of patients with ovarian cancer due to a mismatch repair defect",

abstract = "PURPOSE: Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC-HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC-HNPCC and a control group. METHODS: A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan-Meier analysis was used to calculate the crude survival. RESULTS: The mean age at diagnosis of OC-HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC-HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC-HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1\% respectively. CONCLUSION: On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC",

author = "Crijnen, \{Th E. M.\} and Janssen-Heijnen, \{M. L. G.\} and H. Gelderblom and J. Morreau and Nooij, \{M. A.\} and Kenter, \{G. G.\} and Vasen, \{H. F. A.\}",

year = "2005",

doi = "10.1007/s10689-005-6573-2",

language = "English",

volume = "4",

pages = "301--305",

journal = "Familial cancer",

issn = "1389-9600",

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number = "4",

}

TY - JOUR

T1 - Survival of patients with ovarian cancer due to a mismatch repair defect

AU - Crijnen, Th E. M.

AU - Janssen-Heijnen, M. L. G.

AU - Gelderblom, H.

AU - Morreau, J.

AU - Nooij, M. A.

AU - Kenter, G. G.

AU - Vasen, H. F. A.

PY - 2005

Y1 - 2005

N2 - PURPOSE: Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC-HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC-HNPCC and a control group. METHODS: A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan-Meier analysis was used to calculate the crude survival. RESULTS: The mean age at diagnosis of OC-HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC-HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC-HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1% respectively. CONCLUSION: On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC

AB - PURPOSE: Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC-HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC-HNPCC and a control group. METHODS: A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan-Meier analysis was used to calculate the crude survival. RESULTS: The mean age at diagnosis of OC-HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC-HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC-HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1% respectively. CONCLUSION: On the basis of our findings, we recommend to treat OC-HNPCC similar to sporadic OC

U2 - 10.1007/s10689-005-6573-2

DO - 10.1007/s10689-005-6573-2

M3 - Article

C2 - 16341807

SN - 1389-9600

VL - 4

SP - 301

EP - 305

JO - Familial cancer

JF - Familial cancer

IS - 4

ER -

Survival of patients with ovarian cancer due to a mismatch repair defect

Abstract

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