Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

Vianda S. Stel; Rianne W. de Jong; Anneke Kramer; Anton M. Andrusev; José M. Baltar; Myftar Barbullushi; Samira Bell; Pablo Castro de la Nuez; Harijs Cernevskis; C. cile Couchoud; Johan de Meester; Bjørn O. Eriksen; Liliana Gârneaţă; Eliezer Golan; Jaakko Helve; Marc H. Hemmelder; Kristine Hommel; Kyriakos Ioannou; Faiçal Jarraya; Nino Kantaria; Julia Kerschbaum; Kirill S. Komissarov; Ángela Magaz; Lucile Mercadal; Mai Ots-Rosenberg; Runólfur Pálsson; Axel Rahmel; Helena Rydell; Manuela Savino; Nurhan Seyahi; Maria F. Slon Roblero; Olivera Stojceva-Taneva; Arjan van der Tol; Evgueniy S. Vazelov; Edita Ziginskiene; Óscar Zurriaga; Raymond C. Vanholder; Ziad A. Massy; Kitty J. Jager

doi:10.1016/j.kint.2020.12.010

Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

Vianda S. Stel^*
, Rianne W. de Jong
, Anneke Kramer
, Anton M. Andrusev
, José M. Baltar
, Myftar Barbullushi
, Samira Bell
, Pablo Castro de la Nuez
, Harijs Cernevskis
, C. cile Couchoud
, Johan de Meester
, Bjørn O. Eriksen
, Liliana Gârneaţă
, Eliezer Golan
, Jaakko Helve
, Marc H. Hemmelder
, Kristine Hommel
, Kyriakos Ioannou
, Faiçal Jarraya
, Nino Kantaria

Julia Kerschbaum, Kirill S. Komissarov, Ángela Magaz, Lucile Mercadal, Mai Ots-Rosenberg, Runólfur Pálsson, Axel Rahmel, Helena Rydell, Manuela Savino, Nurhan Seyahi, Maria F. Slon Roblero, Olivera Stojceva-Taneva, Arjan van der Tol, Evgueniy S. Vazelov, Edita Ziginskiene, Óscar Zurriaga, Raymond C. Vanholder, Ziad A. Massy, Kitty J. Jager

^*Corresponding author for this work

University of Amsterdam
Chronic Dialysis, Russia, and CIS Medical Department, Company “Baxter” AO, Moscow, Russia; and Renal Replacement Registry, Russian Dialysis Society, Moscow, Russia
Renal Replacement Registry, Russian Dialysis Society, Moscow, Russia
San Agustín University Hospital, Aviles, Spain
University Medical Center of Tirana "Mother Teresa"
Scottish Renal Registry, Meridian Court, Glasgow, UK; and Division of Population Health and Genomics, University of Dundee, Dundee, UK
University of Dundee
Coordinacion Autonomica de Trasplantes de Andalucia, Sevilla, Spain
Riga Stradins University
Réseau épidémiologie et information en néphrologie
University Hospital of North Norway
University of Tromsø – The Arctic University of Norway
Carol Davila University of Medicine and Pharmacy
Tel Aviv University
Finnish Registry for Kidney Diseases, Helsinki, Finland
University of Helsinki
Dutch Renal Registry, Nefrovisie foundation, Utrecht, The Netherlands
Maastricht UMC+
University of Copenhagen
Cyprus Renal Registry and Nephrology Department, American Medical Center, Nicosia, Cyprus
Nephrology Department, American Medical Center, Nicosia, Cyprus
Nephrology, CHU H Chaker Sfax and LR19ES11, Faculte de Medecine, Sfax, Tunisia
Tbilisi State Medical University
Innsbruck Medical University
Minsk Scientific and Practical Center of Surgery, Transplantation and Hematology, Minsk, Belarus
Unidad de Información sobre Pacientes Renales de la Comunidad Autónoma del País Vasco (UNIPAR), Bilbao, Spain
Assistance publique – Hôpitaux de Paris
Institut national de la santé et de la recherche médicale
University of Tartu
Landspitali University Hospital
University of Iceland
Deutsche Stiftung Organtransplantation, Frankfurt am Main, Germany
Karolinska Institutet
County Hospital Ryhov
North Bristol NHS Trust
Istanbul University
Hospital Virgen del Camino
SS Cyril and Methodius University in Skopje
Ghent University
University Hospital Alexandrovska
Lithuanian Nephrology, Dialysis and Transplantation Association, and Nephrology Department, Medical Academy, Lithuanian University of Health Sciences, Lithuania
Lithuanian University of Health Sciences
Valencia Region Renal Registry, Conselleria de Sanitat, Generalitat Valenciana, València, Spain
University of Valencia
CIBERESP (Spanish Research Consortium on Epidemiology and Public Health), Madrid, Spain
European Kidney Health Alliance, Brussels, Belgium
Université Paris-Saclay
Service de Néphrologie et Dialyse, Hôpital Universitaire Ambroise Paré, Assistance Publique–Hopitaux de Paris, Boulogne Billancourt, France

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources. Through an online survey, responding nephrologists estimated the frequency of CCM (i.e. planned holistic care instead of kidney replacement therapy) in 33 countries. In 2016, the overall incidence of replacement therapy for kidney failure was 132 per million population (pmp), varying from 29 (Ukraine) to 251 pmp (Greece). On 31 December 2016, the overall prevalence of kidney replacement therapy was 985 pmp, ranging from 188 (Ukraine) to 1906 pmp (Portugal). The prevalence of peritoneal dialysis (114 pmp) and home hemodialysis (28 pmp) was highest in Cyprus and Denmark respectively. The kidney transplantation rate was nearly zero in some countries and highest in Spain (64 pmp). In 28 countries with five or more responding nephrologists, the median percentage of candidates for kidney replacement therapy who were offered CCM in 2018 varied between none (Slovakia and Slovenia) and 20% (Finland) whereas the median prevalence of CCM varied between none (Slovenia) and 15% (Hungary). Thus, the substantial differences across Europe in the frequency of kidney replacement therapy and CCM indicate the need for improvement in access to various treatment options for patients with kidney failure.

Original language	English
Pages (from-to)	182-195
Number of pages	14
Journal	Kidney international
Volume	100
Issue number	1
Early online date	2021
DOIs	https://doi.org/10.1016/j.kint.2020.12.010 https://doi.org/10.1016/j.kint.2020.12.010
Publication status	Published - Jul 2021

Keywords

hemodialysis
peritoneal dialysis
transplantation

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Cite this

Stel, V. S., de Jong, R. W., Kramer, A., Andrusev, A. M., Baltar, J. M., Barbullushi, M., Bell, S., Castro de la Nuez, P., Cernevskis, H., Couchoud, C. C., de Meester, J., Eriksen, B. O., Gârneaţă, L., Golan, E., Helve, J., Hemmelder, M. H., Hommel, K., Ioannou, K., Jarraya, F., ... Jager, K. J. (2021). Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe. Kidney international, 100(1), 182-195. https://doi.org/10.1016/j.kint.2020.12.010, https://doi.org/10.1016/j.kint.2020.12.010

@article{a8397dc0e82c44bba2e39cebabd50770,

title = "Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe",

abstract = "The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources. Through an online survey, responding nephrologists estimated the frequency of CCM (i.e. planned holistic care instead of kidney replacement therapy) in 33 countries. In 2016, the overall incidence of replacement therapy for kidney failure was 132 per million population (pmp), varying from 29 (Ukraine) to 251 pmp (Greece). On 31 December 2016, the overall prevalence of kidney replacement therapy was 985 pmp, ranging from 188 (Ukraine) to 1906 pmp (Portugal). The prevalence of peritoneal dialysis (114 pmp) and home hemodialysis (28 pmp) was highest in Cyprus and Denmark respectively. The kidney transplantation rate was nearly zero in some countries and highest in Spain (64 pmp). In 28 countries with five or more responding nephrologists, the median percentage of candidates for kidney replacement therapy who were offered CCM in 2018 varied between none (Slovakia and Slovenia) and 20\% (Finland) whereas the median prevalence of CCM varied between none (Slovenia) and 15\% (Hungary). Thus, the substantial differences across Europe in the frequency of kidney replacement therapy and CCM indicate the need for improvement in access to various treatment options for patients with kidney failure.",

keywords = "hemodialysis, peritoneal dialysis, transplantation",

author = "Stel, \{Vianda S.\} and \{de Jong\}, \{Rianne W.\} and Anneke Kramer and Andrusev, \{Anton M.\} and Baltar, \{Jos{\'e} M.\} and Myftar Barbullushi and Samira Bell and \{Castro de la Nuez\}, Pablo and Harijs Cernevskis and Couchoud, \{C. cile\} and \{de Meester\}, Johan and Eriksen, \{Bj{\o}rn O.\} and Liliana G{\^a}rnea{\c t}{\u a} and Eliezer Golan and Jaakko Helve and Hemmelder, \{Marc H.\} and Kristine Hommel and Kyriakos Ioannou and Fai{\c c}al Jarraya and Nino Kantaria and Julia Kerschbaum and Komissarov, \{Kirill S.\} and {\'A}ngela Magaz and Lucile Mercadal and Mai Ots-Rosenberg and Run{\'o}lfur P{\'a}lsson and Axel Rahmel and Helena Rydell and Manuela Savino and Nurhan Seyahi and \{Slon Roblero\}, \{Maria F.\} and Olivera Stojceva-Taneva and \{van der Tol\}, Arjan and Vazelov, \{Evgueniy S.\} and Edita Ziginskiene and {\'O}scar Zurriaga and Vanholder, \{Raymond C.\} and Massy, \{Ziad A.\} and Jager, \{Kitty J.\}",

note = "Funding Information: The authors would like to thank the patients and staff of all the dialysis and transplant units who have contributed data via their national and regional renal registries to the European Renal Association?European Dialysis and Transplant Association (ERA-EDTA) Registry. In addition, we would like to thank the persons and organizations listed in the paragraph ?AFFILIATED REGISTRIES? for their contribution to the work of the ERA-EDTA Registry. The authors are grateful to all nephrologists and kidney transplant surgeons who completed ?The Effect of Differing Kidney Disease Treatment Modalities and Organ Donation and Transplantation Practices on Health Expenditure and Patient Outcomes? Nephrologist survey. In addition, we would like to thank all colleagues who pretested the survey, provided advice about the ethical approval in their country, or helped to distribute the survey in their country or personal network. This study was funded by the European Union (grant PP-01-2016) and ERA-EDTA. Among others, we are grateful for support from Austria (R. Kramar and R. Oberbauer), Belarus, Belgium (F. Collart), Croatia (I. Bubic, M. Bu?i?, M. Dragovi?, and S. ?iv?i? ?osi?), Cyprus, Czech Republic (I. Rychlik and V. Tesa?), Denmark (J. Heaf and S. Schwartz S?rensen), Estonia, Finland (P. Finne and V. Rauta), Germany (M. Lingemann and C. Wanner), Greece (T. Apostolou, E. Dounousi, and G. Moustakas), Hungary (O. Deme, S. Mihaly, and G. Re?sz), Ireland (W. Plant), Italy (G. Brunori, C. Carella, P. di Ciaccio, and M. Postorino), Latvia (A. Petersons), Malta (J. Buttigieg), Moldova (A. Tanase), the Netherlands (F. van Ittersum and S. Logtenberg), North Macedonia (G. Spasovski), Norway (A. ?sberg, M. Dahl Solbu, and A. Varberg Reis?ter), Poland (S. Dudzicz and M. Nowicki), Romania (L. G?rnea?? and L. Tuta), Russia (H. Zakharova), Serbia (R. Naumovic), Slovakia (V. Spustova), Slovenia (J. Buturovic Ponikvar and D. Kovac), Spain (C. Alberich, J. Comas, M. del Pino y Pino, M. Ferrer Alamar, and B. Mahillo), Sweden (M. Evans), Switzerland (P. Amb?hl and U. Huynh-Do), Turkey (M. Arici), Ukraine (M. Kolesnyk), and United Kingdom (S. Fraser and G. Lipkin); and from the following organizations: EKITA (I. Bellini and R. Langer), ERA-EDTA (F. Trebelli), EuroPD (S. Davies), and Eurotransplant (P. Branger, M. van Meel, and U. Samuel). Affiliated registries. Albanian Renal Registry (M. Barbullushi, A. Idrizi, and E. Bolleku Likaj); Austrian Dialysis and Transplant Registry (OEDTR) (R. Kramar); Belarus Renal Registry (K.S. Komissarov, K.S. Kamisarau, and A.V. Kalachyk); Dutch-speaking Belgian Society of Nephrology (NBVN) (M. Couttenye, F. Schroven, and J. De Meester); French-speaking Belgian Society of Nephrology (GNFB) (J.M. des Grottes and F. Collart); Renal Registry Bosnia and Herzegovina (H. Resi?, Z. Stipancic, and N. Petkovic); Bulgaria (E.S. Vazelov and I. Velinova); Croatian Registry of renal replacement therapy (CRRRT) (I. Bubi? and M. Knotek); Cyprus Renal Registry (K. Ioannou and all of the renal units providing data); Czech Republic: Registry of Dialysis Patients (RDP) (I. Rychl?k, J. Potucek, and F. Lopot); Danish Nephrology Registry (DNS)(J.G. Heaf); Estonian Society of Nephrology (?. Pechter, K. Lilienthal, and M. Rosenberg); Finnish Registry for Kidney Diseases (P. Finne, A. Pylsy, and P.H. Groop); France: The Epidemiology and Information Network in Nephrology (REIN) (M. Lassalle and C. Couchoud); Georgian Renal Registry (N. Kantaria and Dialysis Nephrology and Transplantation Union of Georgia); Hellenic Renal Registry (N. Afentakis); Icelandic ESRD Registry (R. Palsson); Israel National Registry of Renal Replacement Therapy (R. Dichtiar, T. Shohat, and E. Golan); Italian Registry of Dialysis and Transplantation (RIDT) (A. Limido, M. Nordio, and M. Postorino); Latvian Renal Registry (H. Cernevskis, V. Kuzema, and A. Silda); Lithuanian Renal Registry (I.A. Bumblyte, V. Vainauskas, and E. ?iginskien?); Macedonian Renal Registry (M. Nedelkovska, N. Dimitriova, and O. Stojceva-Taneva); Norwegian Renal Registry (T. Leivestad, A.V. Reis?ter, and A. ?sberg); Polish Renal Registry (G. Korejwo, A. D?bska-?lizie?, and R. Gellert); Portuguese Renal Registry (F. Mac?rio and A. Ferreira); Romanian Renal Registry (RRR) (G. Mircescu, L. Garneata, and E. Podgoreanu); Russian Renal Registry (N. Tomilina, A. Andrusev, and H. Zakharova); Renal Registry in Serbia (N. Maksimovic, R. Naumovic, all of the Serbian renal units, and the Serbian Society of Nephrology); Slovakian Renal Registry (V. Spustov?, I. Lajdov?, and M. Karolyova); Spanish RRT National Registry at Organizaci?n Nacional de Trasplantes (ONT), Spanish Regional Registries, Spanish Society of Nephrology (SEN), and the regional registries of Andalusia Sistema de Informaci?n de la Coordinaci?n Auton?mica de Trasplantes de Andalucia (SICATA) (P. Castro de la Nuez [on behalf of all users of SICATA]), Aragon (F. Arribas Monz?n, J.M. Abad Diez, and J.I. Sanchez Miret), Asturias (R. Alonso de la Torre, J.R. Quir?s, and Registro de Enfermos Renales Cr?nicos de Asturias [RERCA] Working Group), Basque country (UNIPAR) (?. Magaz, J. Aranzabal, M. Rodrigo, and I. Moina), Cantabria (J.C. Ruiz San Mill?n, O. Garcia Ruiz, and C. Pi?era Haces), Castile and Le?n (M.A. Palencia Garc?a), Castile?La Mancha (G. Guti?rrez ?vila and I. Moreno Al?a), Catalonia (RMRC) (E. Arcos, J. Comas, and J. Tort), Extremadura (J.M. Ramos Aceitero and M.A. Garc?a Bazaga), Galicia (E. Bouzas-Caama?o), Community of Madrid (M.I. Aparicio de Madre), Renal Registry of the Region of Murcia (C. Santiuste de Pablos and I. Mar?n S?nchez), Navarre (M.F. Slon Roblero, J. Manrique Escola, and J. Arteaga Coloma), and the Valencian region (REMRENAL) (M. Ferrer Alamar, N. Fuster Camarena, and J. P?rez Penad?s); Swedish Renal Registry (SNR) (K.G. Pr?tz, M. Stendahl, M. Evans, S. Sch?n, T. Lundgren, and M. Segelmark); Swiss Dialysis Registry (P. Amb?hl and R. Winzeler); Dutch Renal Registry (RENINE) (L. Heuveling, S. Vogelaar, and M. Hemmelder); Tunisia, Sfax region (F. Jarraya and D. Zalila); Registry of the Nephrology, Dialysis and Transplantation in Turkey (TSNNR) (G. S?leymanlar, N. Seyahi, and K. Ate?); Ukrainian Renal Data System (URDS) (M. Kolesnyk, S. Nikolaenko, and O. Razvazhaieva); UK Renal Registry (UKRR) (all the staff of the UKRR and of the renal units submitting data); and Scottish Renal Registry (SRR) (all of the Scottish renal units). ERA-EDTA Registry committee members. C. Zoccali, Italy (ERA-EDTA President); Z.A. Massy, France (Chairman); F.J. Caskey, United Kingdom; C. Couchoud, France; M. Evans, Sweden; P. Finne, Finland; J.W. Groothoff, the Netherlands; J. Harambat, France; J.G. Heaf, Denmark; F. Jarraya, Tunisia; M. Nordio, Italy; and I. Rychlik, Czech Republic. Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jul,

doi = "10.1016/j.kint.2020.12.010",

language = "English",

volume = "100",

pages = "182--195",

journal = "Kidney international",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "1",

}

Stel, VS , de Jong, RW , Kramer, A, Andrusev, AM, Baltar, JM, Barbullushi, M, Bell, S, Castro de la Nuez, P, Cernevskis, H, Couchoud, CC, de Meester, J, Eriksen, BO, Gârneaţă, L, Golan, E, Helve, J, Hemmelder, MH, Hommel, K, Ioannou, K, Jarraya, F, Kantaria, N, Kerschbaum, J, Komissarov, KS, Magaz, Á, Mercadal, L, Ots-Rosenberg, M, Pálsson, R, Rahmel, A, Rydell, H, Savino, M, Seyahi, N, Slon Roblero, MF, Stojceva-Taneva, O, van der Tol, A, Vazelov, ES, Ziginskiene, E, Zurriaga, Ó, Vanholder, RC, Massy, ZA & Jager, KJ 2021, 'Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe', Kidney international, vol. 100, no. 1, pp. 182-195. https://doi.org/10.1016/j.kint.2020.12.010, https://doi.org/10.1016/j.kint.2020.12.010

Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe. / Stel, Vianda S.; de Jong, Rianne W.; Kramer, Anneke et al.
In: Kidney international, Vol. 100, No. 1, 07.2021, p. 182-195.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

AU - Stel, Vianda S.

AU - de Jong, Rianne W.

AU - Kramer, Anneke

AU - Andrusev, Anton M.

AU - Baltar, José M.

AU - Barbullushi, Myftar

AU - Bell, Samira

AU - Castro de la Nuez, Pablo

AU - Cernevskis, Harijs

AU - Couchoud, C. cile

AU - de Meester, Johan

AU - Eriksen, Bjørn O.

AU - Gârneaţă, Liliana

AU - Golan, Eliezer

AU - Helve, Jaakko

AU - Hemmelder, Marc H.

AU - Hommel, Kristine

AU - Ioannou, Kyriakos

AU - Jarraya, Faiçal

AU - Kantaria, Nino

AU - Kerschbaum, Julia

AU - Komissarov, Kirill S.

AU - Magaz, Ángela

AU - Mercadal, Lucile

AU - Ots-Rosenberg, Mai

AU - Pálsson, Runólfur

AU - Rahmel, Axel

AU - Rydell, Helena

AU - Savino, Manuela

AU - Seyahi, Nurhan

AU - Slon Roblero, Maria F.

AU - Stojceva-Taneva, Olivera

AU - van der Tol, Arjan

AU - Vazelov, Evgueniy S.

AU - Ziginskiene, Edita

AU - Zurriaga, Óscar

AU - Vanholder, Raymond C.

AU - Massy, Ziad A.

AU - Jager, Kitty J.

N1 - Funding Information: The authors would like to thank the patients and staff of all the dialysis and transplant units who have contributed data via their national and regional renal registries to the European Renal Association?European Dialysis and Transplant Association (ERA-EDTA) Registry. In addition, we would like to thank the persons and organizations listed in the paragraph ?AFFILIATED REGISTRIES? for their contribution to the work of the ERA-EDTA Registry. The authors are grateful to all nephrologists and kidney transplant surgeons who completed ?The Effect of Differing Kidney Disease Treatment Modalities and Organ Donation and Transplantation Practices on Health Expenditure and Patient Outcomes? Nephrologist survey. In addition, we would like to thank all colleagues who pretested the survey, provided advice about the ethical approval in their country, or helped to distribute the survey in their country or personal network. This study was funded by the European Union (grant PP-01-2016) and ERA-EDTA. Among others, we are grateful for support from Austria (R. Kramar and R. Oberbauer), Belarus, Belgium (F. Collart), Croatia (I. Bubic, M. Bu?i?, M. Dragovi?, and S. ?iv?i? ?osi?), Cyprus, Czech Republic (I. Rychlik and V. Tesa?), Denmark (J. Heaf and S. Schwartz S?rensen), Estonia, Finland (P. Finne and V. Rauta), Germany (M. Lingemann and C. Wanner), Greece (T. Apostolou, E. Dounousi, and G. Moustakas), Hungary (O. Deme, S. Mihaly, and G. Re?sz), Ireland (W. Plant), Italy (G. Brunori, C. Carella, P. di Ciaccio, and M. Postorino), Latvia (A. Petersons), Malta (J. Buttigieg), Moldova (A. Tanase), the Netherlands (F. van Ittersum and S. Logtenberg), North Macedonia (G. Spasovski), Norway (A. ?sberg, M. Dahl Solbu, and A. Varberg Reis?ter), Poland (S. Dudzicz and M. Nowicki), Romania (L. G?rnea?? and L. Tuta), Russia (H. Zakharova), Serbia (R. Naumovic), Slovakia (V. Spustova), Slovenia (J. Buturovic Ponikvar and D. Kovac), Spain (C. Alberich, J. Comas, M. del Pino y Pino, M. Ferrer Alamar, and B. Mahillo), Sweden (M. Evans), Switzerland (P. Amb?hl and U. Huynh-Do), Turkey (M. Arici), Ukraine (M. Kolesnyk), and United Kingdom (S. Fraser and G. Lipkin); and from the following organizations: EKITA (I. Bellini and R. Langer), ERA-EDTA (F. Trebelli), EuroPD (S. Davies), and Eurotransplant (P. Branger, M. van Meel, and U. Samuel). Affiliated registries. Albanian Renal Registry (M. Barbullushi, A. Idrizi, and E. Bolleku Likaj); Austrian Dialysis and Transplant Registry (OEDTR) (R. Kramar); Belarus Renal Registry (K.S. Komissarov, K.S. Kamisarau, and A.V. Kalachyk); Dutch-speaking Belgian Society of Nephrology (NBVN) (M. Couttenye, F. Schroven, and J. De Meester); French-speaking Belgian Society of Nephrology (GNFB) (J.M. des Grottes and F. Collart); Renal Registry Bosnia and Herzegovina (H. Resi?, Z. Stipancic, and N. Petkovic); Bulgaria (E.S. Vazelov and I. Velinova); Croatian Registry of renal replacement therapy (CRRRT) (I. Bubi? and M. Knotek); Cyprus Renal Registry (K. Ioannou and all of the renal units providing data); Czech Republic: Registry of Dialysis Patients (RDP) (I. Rychl?k, J. Potucek, and F. Lopot); Danish Nephrology Registry (DNS)(J.G. Heaf); Estonian Society of Nephrology (?. Pechter, K. Lilienthal, and M. Rosenberg); Finnish Registry for Kidney Diseases (P. Finne, A. Pylsy, and P.H. Groop); France: The Epidemiology and Information Network in Nephrology (REIN) (M. Lassalle and C. Couchoud); Georgian Renal Registry (N. Kantaria and Dialysis Nephrology and Transplantation Union of Georgia); Hellenic Renal Registry (N. Afentakis); Icelandic ESRD Registry (R. Palsson); Israel National Registry of Renal Replacement Therapy (R. Dichtiar, T. Shohat, and E. Golan); Italian Registry of Dialysis and Transplantation (RIDT) (A. Limido, M. Nordio, and M. Postorino); Latvian Renal Registry (H. Cernevskis, V. Kuzema, and A. Silda); Lithuanian Renal Registry (I.A. Bumblyte, V. Vainauskas, and E. ?iginskien?); Macedonian Renal Registry (M. Nedelkovska, N. Dimitriova, and O. Stojceva-Taneva); Norwegian Renal Registry (T. Leivestad, A.V. Reis?ter, and A. ?sberg); Polish Renal Registry (G. Korejwo, A. D?bska-?lizie?, and R. Gellert); Portuguese Renal Registry (F. Mac?rio and A. Ferreira); Romanian Renal Registry (RRR) (G. Mircescu, L. Garneata, and E. Podgoreanu); Russian Renal Registry (N. Tomilina, A. Andrusev, and H. Zakharova); Renal Registry in Serbia (N. Maksimovic, R. Naumovic, all of the Serbian renal units, and the Serbian Society of Nephrology); Slovakian Renal Registry (V. Spustov?, I. Lajdov?, and M. Karolyova); Spanish RRT National Registry at Organizaci?n Nacional de Trasplantes (ONT), Spanish Regional Registries, Spanish Society of Nephrology (SEN), and the regional registries of Andalusia Sistema de Informaci?n de la Coordinaci?n Auton?mica de Trasplantes de Andalucia (SICATA) (P. Castro de la Nuez [on behalf of all users of SICATA]), Aragon (F. Arribas Monz?n, J.M. Abad Diez, and J.I. Sanchez Miret), Asturias (R. Alonso de la Torre, J.R. Quir?s, and Registro de Enfermos Renales Cr?nicos de Asturias [RERCA] Working Group), Basque country (UNIPAR) (?. Magaz, J. Aranzabal, M. Rodrigo, and I. Moina), Cantabria (J.C. Ruiz San Mill?n, O. Garcia Ruiz, and C. Pi?era Haces), Castile and Le?n (M.A. Palencia Garc?a), Castile?La Mancha (G. Guti?rrez ?vila and I. Moreno Al?a), Catalonia (RMRC) (E. Arcos, J. Comas, and J. Tort), Extremadura (J.M. Ramos Aceitero and M.A. Garc?a Bazaga), Galicia (E. Bouzas-Caama?o), Community of Madrid (M.I. Aparicio de Madre), Renal Registry of the Region of Murcia (C. Santiuste de Pablos and I. Mar?n S?nchez), Navarre (M.F. Slon Roblero, J. Manrique Escola, and J. Arteaga Coloma), and the Valencian region (REMRENAL) (M. Ferrer Alamar, N. Fuster Camarena, and J. P?rez Penad?s); Swedish Renal Registry (SNR) (K.G. Pr?tz, M. Stendahl, M. Evans, S. Sch?n, T. Lundgren, and M. Segelmark); Swiss Dialysis Registry (P. Amb?hl and R. Winzeler); Dutch Renal Registry (RENINE) (L. Heuveling, S. Vogelaar, and M. Hemmelder); Tunisia, Sfax region (F. Jarraya and D. Zalila); Registry of the Nephrology, Dialysis and Transplantation in Turkey (TSNNR) (G. S?leymanlar, N. Seyahi, and K. Ate?); Ukrainian Renal Data System (URDS) (M. Kolesnyk, S. Nikolaenko, and O. Razvazhaieva); UK Renal Registry (UKRR) (all the staff of the UKRR and of the renal units submitting data); and Scottish Renal Registry (SRR) (all of the Scottish renal units). ERA-EDTA Registry committee members. C. Zoccali, Italy (ERA-EDTA President); Z.A. Massy, France (Chairman); F.J. Caskey, United Kingdom; C. Couchoud, France; M. Evans, Sweden; P. Finne, Finland; J.W. Groothoff, the Netherlands; J. Harambat, France; J.G. Heaf, Denmark; F. Jarraya, Tunisia; M. Nordio, Italy; and I. Rychlik, Czech Republic. Publisher Copyright: © 2021 International Society of Nephrology Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/7

Y1 - 2021/7

N2 - The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources. Through an online survey, responding nephrologists estimated the frequency of CCM (i.e. planned holistic care instead of kidney replacement therapy) in 33 countries. In 2016, the overall incidence of replacement therapy for kidney failure was 132 per million population (pmp), varying from 29 (Ukraine) to 251 pmp (Greece). On 31 December 2016, the overall prevalence of kidney replacement therapy was 985 pmp, ranging from 188 (Ukraine) to 1906 pmp (Portugal). The prevalence of peritoneal dialysis (114 pmp) and home hemodialysis (28 pmp) was highest in Cyprus and Denmark respectively. The kidney transplantation rate was nearly zero in some countries and highest in Spain (64 pmp). In 28 countries with five or more responding nephrologists, the median percentage of candidates for kidney replacement therapy who were offered CCM in 2018 varied between none (Slovakia and Slovenia) and 20% (Finland) whereas the median prevalence of CCM varied between none (Slovenia) and 15% (Hungary). Thus, the substantial differences across Europe in the frequency of kidney replacement therapy and CCM indicate the need for improvement in access to various treatment options for patients with kidney failure.

AB - The aims of this study were to determine the frequency of dialysis and kidney transplantation and to estimate the regularity of comprehensive conservative management (CCM) for patients with kidney failure in Europe. This study uses data from the ERA-EDTA Registry. Additionally, our study included supplemental data from Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia and additional data from Israel, Italy, Slovakia using other information sources. Through an online survey, responding nephrologists estimated the frequency of CCM (i.e. planned holistic care instead of kidney replacement therapy) in 33 countries. In 2016, the overall incidence of replacement therapy for kidney failure was 132 per million population (pmp), varying from 29 (Ukraine) to 251 pmp (Greece). On 31 December 2016, the overall prevalence of kidney replacement therapy was 985 pmp, ranging from 188 (Ukraine) to 1906 pmp (Portugal). The prevalence of peritoneal dialysis (114 pmp) and home hemodialysis (28 pmp) was highest in Cyprus and Denmark respectively. The kidney transplantation rate was nearly zero in some countries and highest in Spain (64 pmp). In 28 countries with five or more responding nephrologists, the median percentage of candidates for kidney replacement therapy who were offered CCM in 2018 varied between none (Slovakia and Slovenia) and 20% (Finland) whereas the median prevalence of CCM varied between none (Slovenia) and 15% (Hungary). Thus, the substantial differences across Europe in the frequency of kidney replacement therapy and CCM indicate the need for improvement in access to various treatment options for patients with kidney failure.

KW - hemodialysis

KW - peritoneal dialysis

KW - transplantation

UR - https://www.scopus.com/pages/publications/85102433675

U2 - 10.1016/j.kint.2020.12.010

DO - 10.1016/j.kint.2020.12.010

M3 - Article

C2 - 33359055

SN - 0085-2538

VL - 100

SP - 182

EP - 195

JO - Kidney international

JF - Kidney international

IS - 1

ER -

Stel VS , de Jong RW , Kramer A, Andrusev AM, Baltar JM, Barbullushi M et al. Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe. Kidney international. 2021 Jul;100(1):182-195. Epub 2021. doi: 10.1016/j.kint.2020.12.010, 10.1016/j.kint.2020.12.010

Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

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