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Subjective Cognitive Impairment Can Be Detected from the Decline of Complex Cognition: Findings from the Examination of Remedes 4 Alzheimer’s (R4Alz) Structural Validity

  • Eleni Poptsi
  • , Despina Moraitou*
  • , Emmanouil Tsardoulias
  • , Andreas L. Symeonidis
  • , Magda Tsolaki
  • *Corresponding author for this work
  • Aristotle University of Thessaloniki
  • Greek Association of Alzheimer's Disease and Related Disorders

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

R4Alz is utilized for the early detection of minor neurocognitive disorders. It was designed to assess three main dimensions of cognitive-control abilities: working-memory capacity, attentional control, and executive functioning. Objectives: To reveal the cognitive-control dimensions that can differentiate between adults and older adults with healthy cognition, people with subjective cognitive impairment, and people diagnosed with mild cognitive impairment by examining the factorial structure of the R4Alz tool. Methods: The study comprised 404 participants: (a) healthy adults (n = 192), (b) healthy older adults (n = 29), (c) people with SCI (n = 74), and (d) people diagnosed with MCI (n = 109). The R4Alz battery was administered to all participants, including tests that assess short-term memory storage, information processing, information updating in working memory, and selective, sustained and divided attention), task/rule-switching, inhibitory control, and cognitive flexibility. Results: A two-factorial structural model was confirmed for R4Alz, with the first factor representing “fluid intelligence (FI)” and the second factor reflecting “executive functions (EF)”. Both FI and EFs discriminate among all groups. Conclusions: The R4Alz battery presents sound construct validity, evaluating abilities in FI and EF. Both abilities can differentiate very early cognitive impairment (SCI) from healthy cognitive aging and MCI.
Original languageEnglish
Article number548
JournalBrain Sciences
Volume14
Issue number6
DOIs
Publication statusPublished - 1 Jun 2024
Externally publishedYes

Keywords

  • cognitive flexibility
  • executive function
  • fluid intelligence
  • working memory

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