Subjective cognitive failures and hippocampal volume in elderly with white matter lesions

A G W van Norden; W F Fick; K F de Laat; I W M van Uden; L J B van Oudheusden; I Tendolkar; M P Zwiers; F E de Leeuw

doi:10.1212/01.wnl.0000327564.44819.49

Subjective cognitive failures and hippocampal volume in elderly with white matter lesions

A G W van Norden
, W F Fick
, K F de Laat
, I W M van Uden
, L J B van Oudheusden
, I Tendolkar
, M P Zwiers
, F E de Leeuw

Department of Neurology, Radboud University Nijmegen Medical Centre, Reinier Postlaan 4, PO-box 9101, 6500 HB Nijmegen, The Netherlands.
Donders Institute for Brain, Nijmegen, Netherlands

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Subjective cognitive failures (SCF) and subjective memory failures (SMF) have been reported to be an early predictor of Alzheimer disease (AD) and have been attributed to white matter lesions (WML). Since AD is characterized by hippocampal degeneration, it is surprising that its relation with hippocampal atrophy has been investigated only sparsely. Previous studies on this are rare, limited in sample size, and did not adjust for WML.

OBJECTIVE: To determine the relation between SCF and hippocampal volume in strata of objective cognitive performance among elderly without dementia with incidental WML.

METHODS: The Radboud University Nijmegen Diffusion tensor and MRI Cohort study is a prospective cohort study among 503 subjects with WML aged between 50 and 85 years. All subjects underwent FLAIR and T1 MRI scanning. The amount of SCF and SMF was rated by the Cognitive Failure Questionnaire. Cognitive function was assessed by a cognitive screening battery. Volumetric measures of hippocampus and WML were manually performed. We assessed the relation between hippocampal volume and SCF and SMF adjusted for age, sex, education, depression, intracranial volume, and WML volume.

RESULTS: Subjects with SCF and SMF had lower hippocampal volumes than those without (p = 0.01 and p = 0.02). This was most noteworthy in subjects with good objective cognitive performance (p(trend) = 0.007 and p(trend) = 0.03), and not in those with poor objective cognitive performance.

CONCLUSION: Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions. SCF has a radiologic detectable pathologic-anatomic substrate.

Original language	English
Pages (from-to)	1152-9
Number of pages	8
Journal	Neurology
Volume	71
Issue number	15
DOIs	https://doi.org/10.1212/01.wnl.0000327564.44819.49
Publication status	Published - 7 Oct 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Aged, 80 and over
Alzheimer Disease/epidemiology
Atrophy
Cognition Disorders/epidemiology
Diffusion Magnetic Resonance Imaging
Female
Hippocampus/pathology
Humans
Male
Memory Disorders/epidemiology
Middle Aged
Nerve Fibers, Myelinated/pathology
Neuropsychological Tests
Prospective Studies
Risk Factors
Severity of Illness Index

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10.1212/01.wnl.0000327564.44819.49

Cite this

@article{12248efa6b2e424fbc51cf49ef4fda26,

title = "Subjective cognitive failures and hippocampal volume in elderly with white matter lesions",

abstract = "BACKGROUND: Subjective cognitive failures (SCF) and subjective memory failures (SMF) have been reported to be an early predictor of Alzheimer disease (AD) and have been attributed to white matter lesions (WML). Since AD is characterized by hippocampal degeneration, it is surprising that its relation with hippocampal atrophy has been investigated only sparsely. Previous studies on this are rare, limited in sample size, and did not adjust for WML.OBJECTIVE: To determine the relation between SCF and hippocampal volume in strata of objective cognitive performance among elderly without dementia with incidental WML.METHODS: The Radboud University Nijmegen Diffusion tensor and MRI Cohort study is a prospective cohort study among 503 subjects with WML aged between 50 and 85 years. All subjects underwent FLAIR and T1 MRI scanning. The amount of SCF and SMF was rated by the Cognitive Failure Questionnaire. Cognitive function was assessed by a cognitive screening battery. Volumetric measures of hippocampus and WML were manually performed. We assessed the relation between hippocampal volume and SCF and SMF adjusted for age, sex, education, depression, intracranial volume, and WML volume.RESULTS: Subjects with SCF and SMF had lower hippocampal volumes than those without (p = 0.01 and p = 0.02). This was most noteworthy in subjects with good objective cognitive performance (p(trend) = 0.007 and p(trend) = 0.03), and not in those with poor objective cognitive performance.CONCLUSION: Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions. SCF has a radiologic detectable pathologic-anatomic substrate.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease/epidemiology, Atrophy, Cognition Disorders/epidemiology, Diffusion Magnetic Resonance Imaging, Female, Hippocampus/pathology, Humans, Male, Memory Disorders/epidemiology, Middle Aged, Nerve Fibers, Myelinated/pathology, Neuropsychological Tests, Prospective Studies, Risk Factors, Severity of Illness Index",

author = "\{van Norden\}, \{A G W\} and Fick, \{W F\} and \{de Laat\}, \{K F\} and \{van Uden\}, \{I W M\} and \{van Oudheusden\}, \{L J B\} and I Tendolkar and Zwiers, \{M P\} and \{de Leeuw\}, \{F E\}",

year = "2008",

month = oct,

day = "7",

doi = "10.1212/01.wnl.0000327564.44819.49",

language = "English",

volume = "71",

pages = "1152--9",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "15",

}

TY - JOUR

T1 - Subjective cognitive failures and hippocampal volume in elderly with white matter lesions

AU - van Norden, A G W

AU - Fick, W F

AU - de Laat, K F

AU - van Uden, I W M

AU - van Oudheusden, L J B

AU - Tendolkar, I

AU - Zwiers, M P

AU - de Leeuw, F E

PY - 2008/10/7

Y1 - 2008/10/7

N2 - BACKGROUND: Subjective cognitive failures (SCF) and subjective memory failures (SMF) have been reported to be an early predictor of Alzheimer disease (AD) and have been attributed to white matter lesions (WML). Since AD is characterized by hippocampal degeneration, it is surprising that its relation with hippocampal atrophy has been investigated only sparsely. Previous studies on this are rare, limited in sample size, and did not adjust for WML.OBJECTIVE: To determine the relation between SCF and hippocampal volume in strata of objective cognitive performance among elderly without dementia with incidental WML.METHODS: The Radboud University Nijmegen Diffusion tensor and MRI Cohort study is a prospective cohort study among 503 subjects with WML aged between 50 and 85 years. All subjects underwent FLAIR and T1 MRI scanning. The amount of SCF and SMF was rated by the Cognitive Failure Questionnaire. Cognitive function was assessed by a cognitive screening battery. Volumetric measures of hippocampus and WML were manually performed. We assessed the relation between hippocampal volume and SCF and SMF adjusted for age, sex, education, depression, intracranial volume, and WML volume.RESULTS: Subjects with SCF and SMF had lower hippocampal volumes than those without (p = 0.01 and p = 0.02). This was most noteworthy in subjects with good objective cognitive performance (p(trend) = 0.007 and p(trend) = 0.03), and not in those with poor objective cognitive performance.CONCLUSION: Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions. SCF has a radiologic detectable pathologic-anatomic substrate.

AB - BACKGROUND: Subjective cognitive failures (SCF) and subjective memory failures (SMF) have been reported to be an early predictor of Alzheimer disease (AD) and have been attributed to white matter lesions (WML). Since AD is characterized by hippocampal degeneration, it is surprising that its relation with hippocampal atrophy has been investigated only sparsely. Previous studies on this are rare, limited in sample size, and did not adjust for WML.OBJECTIVE: To determine the relation between SCF and hippocampal volume in strata of objective cognitive performance among elderly without dementia with incidental WML.METHODS: The Radboud University Nijmegen Diffusion tensor and MRI Cohort study is a prospective cohort study among 503 subjects with WML aged between 50 and 85 years. All subjects underwent FLAIR and T1 MRI scanning. The amount of SCF and SMF was rated by the Cognitive Failure Questionnaire. Cognitive function was assessed by a cognitive screening battery. Volumetric measures of hippocampus and WML were manually performed. We assessed the relation between hippocampal volume and SCF and SMF adjusted for age, sex, education, depression, intracranial volume, and WML volume.RESULTS: Subjects with SCF and SMF had lower hippocampal volumes than those without (p = 0.01 and p = 0.02). This was most noteworthy in subjects with good objective cognitive performance (p(trend) = 0.007 and p(trend) = 0.03), and not in those with poor objective cognitive performance.CONCLUSION: Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions. SCF has a radiologic detectable pathologic-anatomic substrate.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease/epidemiology

KW - Atrophy

KW - Cognition Disorders/epidemiology

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Hippocampus/pathology

KW - Humans

KW - Male

KW - Memory Disorders/epidemiology

KW - Middle Aged

KW - Nerve Fibers, Myelinated/pathology

KW - Neuropsychological Tests

KW - Prospective Studies

KW - Risk Factors

KW - Severity of Illness Index

U2 - 10.1212/01.wnl.0000327564.44819.49

DO - 10.1212/01.wnl.0000327564.44819.49

M3 - Article

SN - 0028-3878

VL - 71

SP - 1152

EP - 1159

JO - Neurology

JF - Neurology

IS - 15

ER -

Subjective cognitive failures and hippocampal volume in elderly with white matter lesions

Abstract

UN SDGs

Keywords

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