@inproceedings{e415c816e25842c8bc8d212e15d7e67b,
title = "Studying nanoparticle-3D tumour spheroid interactions in a microfluidic format: Towards the assessment of drug delivery to complex tumour tissues under physiological conditions",
abstract = "Here, we report a microfluidic platform to investigate interactions between drug-loaded nanoconstructs and 3D tumour spheroids under static conditions and flow-based exposure. Experiments are performed using fluorescently labelled silica nanoparticles of various sizes and with different surface coatings, and by measuring optically the nanoparticle penetration depth in tumour spheroids trapped in our microfluidic device. Confocal microscopy imaging reveals superficial penetration of nanoparticles in the tumour spheroids, inversely proportional to the size of the nanoconstructs, and increased penetration under dynamic conditions created by a laminar flow.",
keywords = "Drug delivery and penetration, Microfluidics, Nanoparticles, Tumour spheroids",
author = "Blond{\'e}, \{Jean Baptiste\} and Dhanya Babu and Dwi Priwitaningrum and Adithya Sridhar and Jai Prakash and \{Le Gac\}, S{\'e}verine",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "529--530",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}